Search results for "growth"

The transformation of the Russian defence industry

1995

TRADITIONALLY, THE DEFENCE INDUSTRY constituted the most powerful industrial lobby in the USSR, with an administrative structure at all the organisational levels where its interests could be affected. With a hierarchical and pyramidal structure, the different entities of the sector remained isolated from strictly civilian bodies. The strategic part it played within the organisation of the Soviet Union enabled the defence industry to manage a growing and important volume of resources; on the one hand, it had a special supply system which guaranteed regular high-quality provision of the most advanced technology in the country, as well as highly qualified human resources. On the other hand, th…

Mechanism of action of sphingolipids and their metabolites in the toxicity of fumonisin B1.

2005

Fumonisins are a group of mycotoxins produced primarily by Fusarium moniliforme. Several fumonisins have been isolated through out the years but only fumonisin B1, B2 and B3 are the ones present in naturally contaminated foods, with B1 being the most toxic between them. The structural similarity between sphinganine and fumonisin B1 suggests that the mechanism of action of this mycotoxin is mainly via disruption of sphingolipid metabolism, this is an important step in the cascade of events leading to altered cell growth, differentiation and cell injury. Sphingolipids are a second type of lipid found in cell membranes, particularly nerve cells and brain tissues. Toxicity of fumonisin B1 is gi…

Strontium/lithium ratio in aragonitic shells of Cerastoderma edule (Bivalvia) — A new potential temperature proxy for brackish environments

2015

Abstract Quantitative reconstruction of water temperature from shells of bivalve mollusks is still a very challenging task. For example, in highly variable environments such as intertidal zones, shell oxygen isotope values can only provide reliable temperature estimates if the δ18Owater signature during the time of growth is known. Furthermore, trace element-to-calcium ratios such as Sr/Ca or Mg/Ca often do not serve as reliable paleothermometers, because their incorporation into bivalve shells is known to be strongly biologically controlled. Here, we present a potential novel temperature proxy which is based on the Sr/Lishell ratio of the intertidal bivalve Cerastoderma edule. Up to 81% of…

Towards a unified analysis of brain maturation and aging across the entire lifespan: A MRI analysis

2017

Previous literature about the structural characterization of the human cerebellum is related to the context of a specific pathology or focused in a restricted age range. In fact, studies about the cerebellum maturation across the lifespan are scarce and most of them considered the cerebellum as a whole without investigating each lobule. This lack of study can be explained by the lack of both accurate segmentation methods and data availability. Fortunately, during the last years, several cerebellum segmentation methods have been developed and many databases comprising subjects of different ages have been made publically available. This fact opens an opportunity window to obtain a more extens…

Evaluation of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in cervical cancer: Data from phase 1 and phase 2 studies.

2021

5509 Background: The accelerated FDA approval of pembrolizumab validated the efficacy of anti–PD-(L)1 therapy for pts with recurrent/metastatic cervical cancer; however, the objective response rate (ORR) with pembrolizumab was 14.3% in pts with PD-L1 expressing tumors. HPV infection is implicated in > 95% of cervical cancers and is linked to upregulation of TGF-β signaling. Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of the TGF-βRII receptor (a TGF-β “trap”) fused to a human IgG1 mAb blocking PD-L1. We report pooled safety and efficacy in pts with immune checkpoint inhibitor–naive, recurrent/metastatic cervical cancer treated with…

Predictive Power of the Tumor Oxygenation Status

1999

In most solid tumors the tissue pO2 status is poorer than in normal tissue at the site of tumor growth (for reviews see Vaupel et al., 1996, 1998; Vaupel and Hoeckel, 1998). Peculiarities of tumor tissue oxygenation can mainly be attributed to characteristic structural and functional abnormalities of the tumor microcirculation (perfusion-limited O2 delivery), to a deterioration of the diffusion-geometry (diffusion-limited O2 delivery), and—in some cases—to a reduced O2 carrying capacity of the blood due to tumor-associated anemia.

Transition Metal Catalyzed Olefin, Cycloolefin, and Styrene Polymerization

2013

The sections in this article are History and Trends Polymerization Processes Supported Catalysts and Morphology Control Polymerization Mechanisms and Stereoselectivity History and Principles of Metallocene Catalysis Regio- and Stereoselective Polymerization of α-Olefins Polymerization of Cyclic Olefins, Cyclopolymerization, and Stereoselective Polymerization of Styrene Late Transition Metal Catalysts Transition Metal Catalyzed Copolymerization Acknowledgements

Synthesis of monodisperse oligomers of ɛ-aminocaproic acid up to a degree of polymerization of 25 by the Merrifield method (1)

1967

One-Year Quality of Life Trends in Early-Stage Lung Cancer Patients After Lobectomy

2020

Objective: Quality of Life (QoL) is an important predictor of patient's recovery and survival in lung cancer patients. The aim of the present study is to identify 1-year trends of lung cancer patients' QoL after robot-assisted or traditional lobectomy and investigate whether clinical (e.g., pre-surgery QoL, type of surgery, and perioperative complications) and sociodemographic variables (e.g., age) may predict these trends.Methods: An Italian sample of 176 lung cancer patients undergoing lobectomy completed the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire—Core 30 (QLQ-C30) at the pre-hospitalization (t0), 30 days (t1), 4 months (t2), 8 mon…

Degrees of irreducible characters of the symmetric group and exponential growth

2015

We consider sequences of degrees of ordinary irreducible S n S_n - characters. We assume that the corresponding Young diagrams have rows and columns bounded by some linear function of n n with leading coefficient less than one. We show that any such sequence has at least exponential growth and we compute an explicit bound.