Search results for "growth"
showing 10 items of 5134 documents
Proliferation state and polo-like kinase1 dependence of tumorigenic colon cancer cells.
2012
Abstract Tumor-initiating cells are responsible for tumor maintenance and relapse in solid and hematologic cancers. Although tumor-initiating cells were initially believed to be mainly quiescent, rapidly proliferating tumorigenic cells were found in breast cancer. In colon cancer, the proliferative activity of the tumorigenic population has not been defined, although it represents an essential parameter for the development of more effective therapeutic strategies. Here, we show that tumorigenic colon cancer cells can be found in a rapidly proliferating state in vitro and in vivo, both in human tumors and mouse xenografts. Inhibitors of polo-like kinase1 (Plk1), a mitotic kinase essential fo…
A variant of Smurf2 protects mice against colitis-associated colon cancer by inducing transforming growth factor β signaling.
2011
Background & Aims Transforming growth factor (TGF)-β signaling, which is down-regulated by the E3 ubiquitin ligase Smad ubiquitin regulating factor 2 (Smurf2), promotes development of cancer. We identified a splice variant of Smurf2 (ΔE2Smurf2) and investigated its role in colon carcinogenesis in mice. Methods Colitis-associated colon cancer was induced in mice by administration of azoxymethane, followed by 3 cycles of oral administration of dextran sodium sulfate. Messenger RNA levels of Smurf2 in colon tumors and control tissue were measured by quantitative polymerase chain reaction; lymphocyte and cytokine levels were measured in tumor and tissue samples. Results Tumor-infiltrating CD4 +…
TGF-β Dependent T-Cell Regulation in Colitis and Colon Cancer
2008
Transforming growth factor-β (TGF-β) is a potent growth inhibitor endowed with tumor-suppressing activity. Unfortunately, cancers are often resistant to such growth inhibition. This evasion frequently results from a genetic loss of functional TGF-β signaling components. On the other hand, cancer cells often produce high amounts TGF-β1 by themselves and sometimes respond to it with invasion and metastasis. Much effort is being done to develop therapeutic approaches to modulate TGF-β signaling in cancer cells either to inhibit the TGF-β-induced invasive phenotype or to reestablish its growth-inhibitory activities. However, TGF-β is a pleiotropic cytokine with important functions not only in c…
Parabolic Equations Minimizing Linear Growth Functionals: L1-Theory
2004
Let Ω be a bounded set in ℝN with boundary of class C1. We are interested in the problem $$ \left\{ \begin{gathered} \frac{{\partial u}} {{\partial t}} = diva\left( {x,Du} \right)in Q = \left( {0,\infty } \right) \times \Omega , \hfill \\ u\left( {t,x} \right) = \phi \left( x \right)on S = \left( {0,\infty } \right) \times \partial \Omega , \hfill \\ u\left( {0,x} \right) = u_0 \left( x \right)in x \in \Omega \hfill \\ \end{gathered} \right. $$ (1) where ϕ ∈ L1(∂Ω), u0 ∈ L2(Ω) and a(x, ξ) = ∇ξ f(x, ξ, f being a function with linear growth in ‖ξ‖ as ‖ξ‖ → ∞. One of the classical examples is the nonparametric area integrand for which \( f(x,\xi ) = \sqrt {1 + \left\| \xi \right\|^2 } \). Prob…
Asymptotics for Graded Capelli Polynomials
2014
The finite dimensional simple superalgebras play an important role in the theory of PI-algebras in characteristic zero. The main goal of this paper is to characterize the T 2-ideal of graded identities of any such algebra by considering the growth of the corresponding supervariety. We consider the T 2-ideal Γ M+1,L+1 generated by the graded Capelli polynomials C a p M+1[Y,X] and C a p L+1[Z,X] alternanting on M+1 even variables and L+1 odd variables, respectively. We prove that the graded codimensions of a simple finite dimensional superalgebra are asymptotically equal to the graded codimensions of the T 2-ideal Γ M+1,L+1, for some fixed natural numbers M and L. In particular csupn(Γk2+l2+1…
Varieties with at most quadratic growth
2010
Let V be a variety of non necessarily associative algebras over a field of characteristic zero. The growth of V is determined by the asymptotic behavior of the sequence of codimensions cn(V); n = 1; 2, … and here we study varieties of polynomial growth. Recently, for any real number a, 3 < a < 4, a variety V was constructed satisfying C1n^a < cn(V) < C2n^a; for some constants C1;C2. Motivated by this result here we try to classify all possible growth of varieties V such that cn(V) < Cn^a; with 0 < a < 2, for some constant C. We prove that if 0 < a < 1 then, for n large, cn(V) ≤ 1, whereas if V is a commutative variety and 1 < a < 2, then lim logn cn(V) = 1 o…
On the exponential growth of graded Capelli polynomials
2013
In a free superalgebra over a field of characteristic zero we consider the graded Capelli polynomials Cap M+1[Y,X] and Cap L+1[Z,X] alternating on M+1 even variables and L+1 odd variables, respectively. Here we compute the superexponent of the variety of superalgebras determinated by Cap M+1[Y,X] and Cap L+1[Z,X]. An essential tool in our computation is the generalized-six-square theorem proved in [3].
Guiding the development of community-based services for vulnerable migrants and refugees in Europe
2020
Abstract The Mig-HealthCare roadmap & toolbox emphasize an approach that can be implemented at a local community level by local health professionals. The roadmap and toolbox were the main outcome of the project which combines evidence from original research and other information to present concrete steps in the provision of care to migrants and refugees at a community level. The vision of Mig-HealthCare for this roadmap & toolbox is to (1) Help the health professionals working primarily at the community health care level to familiarize themselves with the key areas of importance in refugee/migrant health (2) Provide health professionals with a valuable set of best practices and hand…
Ranking Lists and European Framework Programmes
2011
The operational context for higher education institutions has become increasingly competitive: universities have to compete on national and international markets for students, staff, funding and prestige. The emergence of various markets, market mechanisms and competition in higher education have become a well-established and much discussed fact, and have shaped the dynamics of the higher education arena (Enders & Jongbloed 2007; Texeira et al. 2004) In a global competition of knowledge societies, higher education institutions have been vested with the task of economic and social change, and are expected to contribute to the competitiveness of nationstates as well as their local communities.
The Past and Future of Innovations in Microfinance
2012
The microfinance industry carries every sign of an innovation in its take-off phase. The various aspects of the microfinance innovation were developed in the 1980’s, twenty years later the industry experiences a phenomenal growth rate, and it has diffused to most developing countries in the world. This review paper looks at microfinance as an entrepreneurial activity in its own right, contributing to the development of small and medium-sized firms in developing countries. We trace the innovations in microfinance, for instance group lending, loans to women, and their financing, and we ask whether the business model implied is sustainable once diffusion has gone far, competition enters, and c…