Search results for "growth"

Chamazulene-Rich Artemisia arborescens Essential Oils Affect the Cell Growth of Human Melanoma Cells

2020

Artemisia arborescens is an aromatic shrub whose essential oils are considered a potential source of molecules with industrial and pharmaceutical interest. The chemical profile of A. arborescens essential oils (EOs) was shown to be quite variable and various chemotypes have been identified. In this study, we compared the EOs composition of A. arborescens leaves and flowers collected from four different locations in Sicily. The EOs were assayed for their antiproliferative activity against A375 human malignant melanoma cells, also testing cell viability and cell membrane integrity. The evaluation of DNA fragmentation and caspase-3 activity assay was employed for the detection of apoptosis. Th…

Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression.

2008

Background & Aims Foxp3-expressing regulatory T cells (Tregs) play a key role in the maintenance of the gut immune homeostasis, and an intact transforming growth factor (TGF)-β signaling is required for their function. In inflammatory bowel disease (IBD), the TGF-β signaling is impaired because of high expression of the inhibitory molecule Smad7. Although no intrinsic defects in Tregs function have been shown in IBD, it is still unknown whether colitogenic T cells are susceptible to Treg-mediated suppression. In this study, we have investigated whether IBD mucosal CD4+ T cells are resistant to Tregs and whether Smad7 is involved in this process. Methods IBD lamina propria mononuclear cells …

Demonstration of a correlation between young leaves, apex and young bunches specific to a young grapevine cutting in the first period of its developm…

2001

<p style="text-align: justify;">The development of hardwood cutting of grapevine comprise 4 succesive phases. Phase I: first period of shoot extension. Phase II: characterized by a slow growth due to a very low activity of the terminal bud. Phase III: reactivation of the growth consecutive to a resumption of the apical activity. Phase IV: when the growth becomes maximal.</p><p style="text-align: justify;">The objective of this work has been to identify the cause of the slowdown of the activity of apical bud during the phase II.</p><p style="text-align: justify;">In a first experiment, we have compared the effects of three modes of defoliation applied from the b…

Biologically active organic compounds, especially plant promoters, in algae extracts and their potential application in plant cultivation

2015

Scientific efforts taken during the past decades undoubtedly have proven that algae are organisms wealthy in various chemical substances such as carbohydrates, proteins, and minerals, as well as polysaccharides, polyphenols, phlorotannins, pigments, unsaturated fats, sterols, and of course growth promoting substances like phytohormones. It is noteworthy that among the many biologically active compounds obtained from seaweeds, plant hormones seem to be the most essential for enhancing the growth and development of crop plants. This fact is well reflected in over 60 years of the long history of controlled application of algae origin products as natural fertilizers in crop production. Neverthe…

Suunnittelijat innovaatiotoiminnan ja kasvun ytimessä

2010

Glutathione in Cancer Cell Death

2011

Glutathione (L-γ-glutamyl-L-cysteinyl-glycine; GSH) in cancer cells is particularly relevant in the regulation of carcinogenic mechanisms; sensitivity against cytotoxic drugs, ionizing radiations, and some cytokines; DNA synthesis; and cell proliferation and death. The intracellular thiol redox state (controlled by GSH) is one of the endogenous effectors involved in regulating the mitochondrial permeability transition pore complex and, in consequence, thiol oxidation can be a causal factor in the mitochondrion-based mechanism that leads to cell death. Nevertheless GSH depletion is a common feature not only of apoptosis but also of other types of cell death. Indeed rates of GSH synthesis and…

Micropropagazione di Platycodon grandiflorus

2009

Barriers and (im)mobility in Rio de Janeiro

2016

In Rio de Janeiro, immobility or the share of people with no journeys on any given day is very high (46%). Immobility has a marked geographical dimension in what is a segregated city. But income has only limited explanatory power. The population structure, with high proportions of people who are not in the labour force and who are unemployed, accounts for the high levels of immobility in the poor districts. Although population structure effects prevail, spatial factors such as the severance effect also account for differences between districts. Indeed, Rio de Janeiro features many different types of barriers that affect immobility in several districts and for several population groups. The…

A (1->3)-beta-D-glucan recognition protein from the sponge Suberites domuncula. Mediated activation of fibrinogen-like protein and epidermal growth f…

2004

Sponges (phylum Porifera) live in a symbiotic relationship with microorganisms, primarily bacteria. Until now, molecular proof for the capacity of sponges to recognize fungi in the surrounding aqueous milieu has not been available. Here we demonstrate, for the demosponge Suberites domuncula (Porifera, Demospongiae, Hadromerida), a cell surface receptor that recognizes (1--3)-beta-D-glucans, e.g. curdlan or laminarin. This receptor, the (1--3)-beta-D-glucan-binding protein, was identified and its cDNA analysed. The gene coding for the 45 kDa protein was found to be upregulated in tissue after incubation with carbohydrate. Simultaneously with the increased expression of this gene, two further…

How is the biocompatibilty of dental biomaterials evaluated?

2007

All biomaterials used in dentistry must be evaluated for biocompatibility using screening assays to protect patient health and safety. The purpose of this review is to explain the international biocompatibility guidelines, and to explain the structure of a test program. The test program requires the structured assessment of materials into four phases; general toxicity, local tissue irritation, pre-clinical, and clinical evaluation. Different types of screening assays are available, and it is important to understand the advantages and limitations of the various types of assays that are available, so that they can be selected for appropriateness and interpreted accurately. New scientific adva…