Search results for "growth"

Structural Growth Disengagement and Entrepreneurship in Small and Micro-Firms. Mapping Pathologies and Physiologies of “Business Dwarfism” in a Dynam…

This paper focuses growth disengagement, in the perspective of those firms who have been keeping their structures, processes and relational systems unchanged for a very long time. The implicit hypothesis according to which such businesses are affected by a structural disease, are not able to create any significant value, and characterised by similar features, is critically discussed. Through an analysis of the phenomenon in the business growth and dynamic resource-based-view, a first attempt taxonomy, based on case-studies, is sketched. It is demonstrated how the implicit assumption according to which such firms are affected by a pathological condition is false, at least if seen as an a pri…

Managing Metro Manila

2017

Metro Manila residents are confronted everyday with the challenges of flooding, substandard housing and horrendous traffic. In this low altitude plain, any significant rainfall raises water levels in many small streams, and contributes to traffic jams. The rapid population growth of the metropolis has led to the proliferation of squatter areas, including alongside flood-prone rivers and railroad tracks. The lack of discipline and of decent garbage management contribute in turn to a worsening of floods when streams are covered with litter. The fast rise in motorization rates, coupled with the many imperfections of the public transport system, make Manila one of the most congested cities in t…

Differential effect of TGF-β family members on proliferation and migration in primary liver cancer

2019

Cancer Stem Cells: From Birth to Death

2019

Abstract Conspicuous investigations have proven the role of cancer stem cells (CSCs) in the onset and progression of a plethora of liquid and solid neoplasms. CSCs are endowed with the capability of initiating tumor growth and becoming dormant at distant organ sites just waiting for optimal conditions amenable for metastatic outgrowth. This cancer subpopulation is inherently resistant to anticancer therapeutics, and its targeting could avoid metastatic disease, which is largely incurable, and clinical relapses. CSCs are considered the Achilles heel of cancer. However, many efforts are necessary to identify univocal CSC markers as well as specific CSC biomarkers of therapeutic response. Here…

Numerical 3D study of FZ growth: dependence on growth parameters and melt instability

2001

Three-dimensional modelling of the floating zone (needle-eye) crystal growth process is carried out to analyse numerically the stability of the melt flow and the influence of the crystal rotation rate and inductor slit width on the 3D flow field and on the grown crystal resistivity. The unsteadiness of the melt is simulated and it is found that for the considered growth parameters a steady-state flow can be a reasonable approximation to the unsteady melt motion. The parametric studies have shown that increasing the rotation rate essentially changes the flow pattern and weakens the rotational striations, while the inductor slit width has a more local influence on these characteristics.

Do Firms Share the Same Functional Form of Their Growth Rate Distribution? A New Statistical Test

2011

We propose a hypothesis testing procedure to investigate whether the same growth rate distribution is shared by all the firms in a balanced panel or, more generally, whether they share the same functional form for this distribution, without necessarily sharing the same parameters. We apply the test to panels of US and European Union publicly quoted manufacturing firms, both at the sectoral and at the subsectoral NAICS levels. We consider the following null hypotheses about the growth rate distribution of the individual firms: i) an unknown shape common to all firms, with all the firms sharing also the same parameters, or with the firm variance related to its firm size through a scaling rela…

Could growth hormone play a role in Peutz Jeghers syndrome?

2013

Convincing experimental data suggest that the growth hormone (GH)/insulin-like growth factor-1(IGF-1) axis plays an important role in cancer development and behaviour. Epidemiological studies have supported an association with cancer, but not with tumour induction per se, although this is a distinction that is important mechanistically but not clinically [1]. We report the case of a 17-year-old man with delayed growth of pituitary origin, treated with growth hormone, in whom a diagnosis of Peutz-Jeghers syndrome (PJS) was subsequently made, and in whom, during the endoscopic follow-up, the number of polyps reduced dramatically, thus suggesting a role for GH in eliciting this disease.

Intravitreal dexamethasone as an enhancer for the anti-VEGF treatment in neovascular ARMD: recovering an old ally

2010

Mechanisms of Autocrine and Paracrine Growth Control in Acute Myelogenous Leukemia

1990

Blast cells of a high proportion of patients with acute myelogenous leukemia (AML) proliferate in response to exogenous hematopoetic growth factors, both in vitro [9, 14, 26, 36, 48, 65] and in vivo [20]. Whereas leukemic colony-forming cells (L-CFCs) from most patients share their growth factor dependence with normal committed myeloid progenitor cells (CFU-GMs), some AML samples autonomously form colonies in agar and are therefore believed to bypass growth factor requirements [17, 42, 72]. Autocrine growth factor production has been identified as one mechanism used by AML blasts to supply various growth-promoting molecules. Moreover nontransformed accessory bone marrow cells have been show…

Competitiveness Gap of the European Union Member Countries in the Context of Europe 2020 Strategy

2015

Abstract This paper is addressing issues of the competitiveness gap of the European Union member countries in the context of Europe 2020 strategy's smart growth. Authors are examining current competitiveness situation when economic performance of some countries are significantly better than others and how does it fit in the competitiveness framework set by Europe 2020 strategy. To have a closer look at the smart growth of European Union member countries authors examine R&D expenditures and their impact on patents and high-technology share in exports as one of the indicators of the competitiveness.