Search results for "growth"

Low molecular weight heparins in cancer patients: to treat thromboembolic events, the tumor, or both?

2011

The interrelationship between cancer and thrombosis is well known. Recent data help physicians to optimize the management of thrombotic complications occurring in cancer patients. However, many issues are still uncertain. First, although the development of venous thromboembolism (VTE) in a patient with known cancer is the most common presentation, concerns remain about the optimal duration and dosages of anticoagulants. Questions also arise concerning the need to implement heparin prophylaxis in the course of chemotherapy. Secondly, in some patients, thrombosis precedes the diagnosis of malignancy. In this case, the question is whether or not to screen patients for an occult cancer. Thirdly…

EGF-Induced Acetylation of Heterogeneous Nuclear Ribonucleoproteins Is Dependent on KRAS Mutational Status in Colorectal Cancer Cells.

2015

KRAS mutational status is considered a negative predictive marker of the response to anti-EGFR therapies in colorectal cancer (CRC) patients. However, conflicting data exist regarding the variable response to EGFR-targeted therapy. The effects of oncogenic KRAS on downstream targets were studied in cell lines with different KRAS mutations. Cells harboring a single KRASG13D allele showed the most tumorigenic profile, with constitutive activation of the downstream pathway, rendering them EGF-unresponsive. Conversely, KRASA146T cells showed a full EGF-response in terms of signal transduction pathways, cell proliferation, migration or adhesion. Moreover, the global acetylome of CRC cells was al…

The quest for promoting integrated care in the Nordic countries – recent reform initiatives, outcomes and obstacles

2013

Coordination between primary and secondary health care has been the core of Nordic health policy during the last decade [1]. In 2012, Norway introduced a cooperation reform aiming for strengthening integration between primary and secondary health care [2]. Previously, Denmark introduced in 2007 “The Local Government Reform” to improve integration in the health care sector. During the last decades, Sweden has restructured for a more community oriented health care system [4]. The objective of the paper are to compare integrated health policy measures and reforms and their outcomes in Denmark, Sweden and Norway, with regard to success and obstacles for improving “seamless” health care. Current…

FETAL GROWTH RESTRICTION: A GROWTH PATTERN WITH FETAL, NEONATAL AND LONG-TERM CONSEQUENCES

2019

Fetal growth restriction (FGR) or intrauterine growth restriction (IUGR) are the terms used for a fetus which has not attained its full growth potential for gestational age. FGR is a multifactorial syndrome responsible for increased fetal and neonatal morbidity and mortality as well as long term adverse outcomes involving auxological, metabolic, organic and functional domains. Clinicians distinguish early and late onset FGR, in relation to specific fetal anthropometric parameters related to the possible primary etiology and to different patterns of placental and maternal cardiovascular pathologies. Delivery of an early onset FGR or growth impaired newborn with congenital pathology should be…

Burnout, work engagement and workaholism among highly educated employees: Profiles, antecedents and outcomes

2014

The present study examined the longitudinal profiles of burnout, engagement and workaholism among highly educated employees. First, the latent profile modeling indicated two latent classes: Engaged and Exhausted-Workaholic. Second, the results revealed that employees with the Engaged profile experienced high levels of energy and dedication, whereas employees with the Exhausted-Workaholic profile experienced exhaustion, cynicism and workaholism. Social pessimism in the transition from high education to work predicted poor subjective well-being at work. Further, workaholism decreased during the career among members of the Exhausted-Workaholic profile suggesting positive direction during caree…

Social orphanhood in Latvia

2014

The reform processes and the developments of social policy to solve the major social problems of the socially vulnerable population, among them, children in particular, take place in Latvia during the last 20 years. Protection of children rights is declared one of the strategic priorities of the state social policy. At the same time the problem of child neglect and child abandonment in Latvia has not yet been sufficiently conceptualized. Already since 1990-ies Latvian society has clearly faced with an objective necessity of solving problems of child abandonment in connection with an increasing number of social orphans. The situation was complicated by the fact that the formation of a fundam…

Effects of canopy covering on yield and quality of ‘Nero d’Avola’ (Vitis vinifera L.) grown in hot-arid climate condition

The impact of climate change on grapevine ecophysiology and vineyard management is predicted to be a serious problem in the next years. In fact, it has an influence on the fruit-set, yield, and in modulating decoupling between technological and phenolic ripening. Thus, it is essential to identify costeffective and easy-to-implement solutions to deal with the issue. For this purpose, the present study aims to test different shade treatments (ST) applied directly to the canopy of ′Nero d’Avola′ cultivar (Vitis vinifera L.), trying to limit the excess of light and heat that, usually occur in hot-arid climate areas as in Sicily. Two ST were imposed during the 2020 vegetative season from fruit s…

Empirical links between natural mortality and recovery in marine fishes

2017

Probability of species recovery is thought to be correlated with specific aspects of organismal life history, such as age at maturity and longevity, and how these affect rates of natural mortality ( M ) and maximum per capita population growth ( r max ). Despite strong theoretical underpinnings, these correlates have been based on predicted rather than realized population trajectories following threat mitigation. Here, we examine the level of empirical support for postulated links between a suite of life-history traits (related to maturity, age, size and growth) and recovery in marine fishes. Following threat mitigation (medium time since cessation of overfishing = 20 years), 71% of 55 tem…

Life Skills e formazione iniziale dei docenti

2022

challenges of everyday life. Learning to live involves acquiring many skills, for which in some cases there is a natural predisposition, but which always require a "guided" exercise in real life contexts so that the person acquires the skills necessary to "live properly". The research was conducted with a group of 153 students from the Master of Science in Primary Education, who participated in a two-year training project during the academic years 2020-21 and 2021-22. This article describes whether and to what extent the students believe they have developed the four chosen life skills and which of the training methodologies adopted by the lecturers were most effective.

Temperature effects explain continental scale distribution of cyanobacterial toxins

2018

Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other classes, such as neurotoxins (e.g., anatoxin-a) and cytotoxins (e.g., cylindrospermopsin) due to their potency. Most studies examine the relationship between individual toxin variants and environmental factors, such as nutrients, temperature and light. In summer 2015, we collected samples across Europe to investigate the effect of nutrient and temperature gradients on the variability of toxin production at a continental scale. Direct and indirect…