Search results for "growth"
showing 10 items of 5134 documents
FGFR2mutation in 46,XY sex reversal with craniosynostosis
2015
Patients with 46,XY gonadal dysgenesis (GD) exhibit genital anomalies, which range from hypospadias to complete male-to-female sex reversal. However, a molecular diagnosis is made in only 30% of cases. Heterozygous mutations in the human FGFR2 gene cause various craniosynostosis syndromes including Crouzon and Pfeiffer, but testicular defects were not reported. Here, we describe a patient whose features we would suggest represent a new FGFR2-related syndrome, craniosynostosis with XY male-to-female sex reversal or CSR. The craniosynostosis patient was chromosomally XY, but presented as a phenotypic female due to complete GD. DNA sequencing identified the FGFR2c heterozygous missense mutatio…
IAP proteins as targets for drug development in oncology.
2013
The inhibitors of apoptosis (IAPs) constitute a family of proteins involved in the regulation of various cellular processes, including cell death, immune and inflammatory responses, cell proliferation, cell differentiation, and cell motility. There is accumulating evidence supporting IAP-targeting in tumors: IAPs regulate various cellular processes that contribute to tumor development, such as cell death, cell proliferation, and cell migration; their expression is increased in a number of human tumor samples, and IAP overexpression has been correlated with tumor growth, and poor prognosis or low response to treatment; and IAP expression can be rapidly induced in response to chemotherapy or …
Trastuzumab-emtansine induced pleural and pericardial effusions
2021
Introduction Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate which combine trastuzumab (T), a monoclonal antibody targeting the human epidermal growth factor receptor-2 (HER2), and a cytotoxic molecule derived from maytansine (DM1). Case report We report the first case of T-DM1-associated pleural and pericardial effusions three weeks after the second course of T-DM1 in a patient with breast cancer. Drug-induced pleural and pericardial effusions was implicated in the absence of other etiologies. The Naranjo Scale indicated a probable drug-induced adverse reaction. Management & outcome: The patient fully recovered after thoracentesis and discontinuation of T-DM1. The patient h…
Parathyroid hormone-related peptide and 8701-BC breast cancer cell growth and invasion in vitro: evidence for growth-inhibiting and invasion-promotin…
1995
It has been previously reported that 8701-BC cells, derived from a primary carcinoma of the breast, constitutively express parathyroid hormone-related peptide (PTHrP) gene and that N-terminal PTHrP immunoreactivity can be found in cell medium. Here we have firstly measured immunoreactive PTHrP in 8701-BC cell medium using antibodies raised against midregion and C-terminal fragments, and also demonstrated the expression of PTH/PTHrP receptor by 8701-BC cells. Secondly, we have examined the role, if any, elicited by diverse PTHrP domains on 8701-BC cell proliferation, and invasive behaviour in vitro related to production of extracellular proteolytic enzymes. Our data show that PTHrP [1-34], a…
Regulation of Apoptosis by Inhibitors of Apoptosis (IAPs).
2013
Abstract Inhibitors of Apoptosis (IAPs) are a family of proteins with various biological functions including regulation of innate immunity and inflammation, cell proliferation, cell migration and apoptosis. They are characterized by the presence of at least one N-terminal baculoviral IAP repeat (BIR) domain involved in protein-protein interaction. Most of them also contain a C-terminal RING domain conferring an E3-ubiquitin ligase activity. In drosophila, IAPs are essential to ensure cell survival, preventing the uncontrolled activation of the apoptotic protease caspases. In mammals, IAPs can also regulate apoptosis through controlling caspase activity and caspase-activating platform format…
Mycelium Growth and Biological Efficiency of Ganoderma lucidum on Substrate Supplemented with Different Organic Additives
2015
Ganoderma lucidum (W. Curt.: Fr) P. Karst. is a mushroom exhibiting various medicinal properties, popular particularly in Asia. It is grown on a substrate based on hardwood sawdust. Other organic materials, usually agricultural or industrial waste supplemented with various additives, are also used in the cultivation of this mushroom. Numerous studies have shown that the composition of the substrate has a significant effect on mycelium growth and biological efficiency of Reishi mushroom. The presented analysis determined the effect of different organic substances on mycelium growth and biological efficiency of several G. lucidum isolates (Gan 18, Gan Li 27/3, Gan 7, Gan 112) obtained from mu…
Characterisation of single semiconductor nanowires by non-destructive spectroscopies
2015
Los nanohilos semiconductores (NWs, de su nombre inglés, nanowires) tienen una amplia gama de aplicaciones en el campo de la optoelectrónica (emisores de luz y diodos láser), nano-electrónica (circuitos lógicos y transistores de efecto de campo), y detección y producción de energía (células solares). En términos generales, los NWs pueden ser descritos como nanoestructuras de forma alargada con diámetros que van típicamente de decenas a cientos de nanómetros, y con longitudes que oscilan desde pocas hasta las decenas de micras. Dicha morfología ofrece dos ventajas principales en comparación con las capas: su alta relación superficie-volumen y su mayor calidad cristalina, ambas beneficiosas p…
Nicotinic receptor agonists as neuroprotective/neurotrophic drugs. Progress in molecular mechanisms
2007
In the present work we reviewed recent advances concerning neuroprotective/neurotrophic effects of acute or chronic nicotine exposure, and the signalling pathways mediating these effects, including mechanisms implicated in nicotine addiction and nAChR desensitization. Experimental and clinical data largely indicate long-lasting effects of nicotine and nicotinic agonists that imply a neuroprotective/neurotrophic role of nAChR activation, involving mainly alpha 7 and alpha 4 beta 2 nAChR subtypes, as evidenced using selective nAChR agonists. Compounds interacting with neuronal nAChRs have the potential to be neuroprotective and treatment with nAChR agonists elicits long-lasting neurotrophic e…
Pedagogical leadership to support new teachers' growth
2016
This study aims to discover the impact of pedagogical leadership on new teachers’ growth. The research is focused on three questions: 1) Are new teachers’ feelings and challenges being understood?; 2) How do new teachers receive support from principals and the school community?; and 3) How does pedagogical leadership impact new teachers’ growth? The research uses the qualitative approach of case studies. Four Finnish schools were selected as participants. The principals of each school and their five new teachers, with less than three years of experience, participated in the interviews. Teachers in Finland have common challenges when they first enter the profession. Finnish school communitie…
Global epidemiology of coronavirus disease 2019 and lessons for effective control of this and future pandemics
2021
Barely 1 year after severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was first reported in China, the virus has infected approximately 120 million people, caused around 3 million deaths, and adversely affected the global economy Despite stringent measures to flatten the epidemiologic curve of the pandemic, there have been spikes and waves of the infection in many countries, particularly in the American, European, and Asian continents This review critically evaluated the global epidemiology of the novel coronavirus disease 2019 (COVID-19) to provide advice on other possible ways of managing the disease as various COVID-19 vaccines are being rolled out To effectively control this …