Search results for "growth"
showing 10 items of 5134 documents
Development of New Targeted Inulin Complex Nanoaggregates for siRNA Delivery in Antitumor Therapy.
2021
Here, a novel strategy of formulating efficient polymeric carriers based on the already described INU-IMI-DETA for gene material whose structural, functional, and biological properties can be modulated and improved was successfully investigated. In particular, two novel derivatives of INU-IMI-DETA graft copolymer were synthesized by chemical functionalisation with epidermal growth factor (EGF) or polyethylenglycol (PEG), named INU-IMI-DETA-EGF and INU-IMI-DETA-PEG, respectively, in order to improve the performance of already described “inulin complex nanoaggregates” (ICONs). The latter were thus prepared by appropriately mixing the two copolymers, by varying each component from 0 to 100 wt%…
Management Simulator as an Instrument to Aid Turning “Stunted Growth” Round in Family Businesses
2008
This paper is the fourth in a series which has described the role and construction of simulation models and a ‘Management Flight Simulator’ that could aid the entrepreneur-owners of so-called ‘dwarf’ or ‘stunted growth’ small firms to break out from the constraints holding them back. While the research presented to date has highlighted the issues in such companies, and has suggested that in many situations relatively simple changes only might be needed to unleash the growth potential of such firms, effecting such changes is not likely to be that “simple” in real life. It has to be possible for affected owner-entrepreneurs to understand a number of factors: that there is a problem (or opport…
Leadership Styles and the Moral Choice of Internal Auditors
2010
Internal auditors’ performance largely depends on their moral decisions when faced with ethical dilemmas. This study explores the impacts of different leadership styles on internal auditors’ moral choice using ERG theory and Path-goal theory. The findings of the survey demonstrated support for both theories. Regression analysis revealed that a sample of West Australian internal auditors were motivated by growth needs and the motivation was enhanced if the leader took a Standard-achievement-oriented approach. Gender appeared as an important predictor and female respondents in the survey were younger and less experienced than their male counterparts and appeared less motivated towards moral c…
MVU ekonomiskās izaugsmes noteicēji Vācijā un Latvijā, fokuss uz ražošanas MVU
2021
Šis darbs ir veltīts mazo un vidējo uzņēmumu (MVU) un to izaugsmes faktoru analīzei. Tajā izklāstīti dažādi faktori, kas ietekmē MVU attīstību, kā arī izaicinājumi un perspektīvas, ar ko tie sastopas mūsdienu globalizētajā un digitalizētajā ekonomikā. Darbā plaši iztirzāta MVU būtiskā loma ekonomikas un sociālās dimensijas iekļaujošā izaugsmē. Šajā darbā arī iekļautas dažādas stratēģijas un valsts programmas, kam ir labvēlīgs iespaids uz uzņēmumu produktivitāti un attīstību. Padziļinātas izpratnes radīšanai kā piemērs ir izvēlēts mazo un vidējo uzņēmumu sektors Latvijā un Vācijā, identificējot abu sektoru trūkumus un priekšrocības.
Maturation of Epidermal Langerhans Cells In Vitro Is Accompanied by Downregulation of 4F2 (CD98) as Determined by Differential Display
1998
Following short-term culture, Langerhans cells mature morphologically and functionally into potent immunostimulatory cells. As regulation of gene expression accompanies this maturation process, it is likely that differentially expressed genes are involved in the maturation events. Using the recently described method of differential display, we generated cDNA expression patterns starting with mRNA of murine epidermal Langerhans cells isolated either directly (fLC) or following 3 d cultivation (cLC). Five hundred putative differentially expressed cDNA fragments were recovered from the gel. For a part of the fragments differential expression was confirmed by dot blot and Southern hybridization…
Bi-2212 and Y123 highly curved single-crystal-like objects: whiskers, bows and ring-like structures
2012
High-temperature superconducting objects of Bi2Sr2CaCu2O8 and Y Ba2Cu3O7 highly curved in the ab-plane, such as curved/kinked whiskers, bows and ring-like structures, were obtained within a solid?liquid?solid (SLS) grass-like growth mechanism. As-grown objects are crystals with three-dimensional epitaxy similar to conventional single crystals: they can be viewed as crystal parts ?cut? from a conventional rectangular crystal. Between our curved objects and conventional crystals, whiskers or thin films there are some differences in the superconducting properties induced only by the shape factors and no new physics is observed. Some details of the growth mechanism are discussed, emphasizing cu…
Systemic blockade of ACVR2B ligands attenuates muscle wasting in ischemic heart failure without compromising cardiac function
2020
Signaling through activin receptors regulates skeletal muscle mass and activin receptor 2B (ACVR2B) ligands are also suggested to participate in myocardial infarction (MI) pathology in the heart. In this study, we determined the effect of systemic blockade of ACVR2B ligands on cardiac function in experimental MI, and defined its efficacy to revert muscle wasting in ischemic heart failure (HF). Mice were treated with soluble ACVR2B decoy receptor (ACVR2B-Fc) to study its effect on post-MI cardiac remodeling and on later HF. Cardiac function was determined with echocardiography, and myocardium analyzed with histological and biochemical methods for hypertrophy and fibrosis. Pharmacological blo…
Incarcerated women, welfare services and the process of re-entering society in Finland
2020
The pathways in and out of crime differ according to gender, people’s life histories, social situations and networks. Before being sentenced, many women have been living in vulnerable and traumatic life situations and violent relationships. Substance abuse often plays a crucial role in committing crimes. Being released from prison and re-entering society is a process that requires women’s own motivation to desist along with help and support from society. This chapter shows how women narrate and describe their experiences after being released from prison and especially how they report the ways in which the welfare system responds to their needs. They discussed their needs for support and ser…
Why am I an alien in my own country? : communication problems that Finnish higher education level students encounter when returning to their home cou…
2007
The Role of Corporate Social Responsibility (CSR) in the New Economy
2004
The idea of corporate social responsibility has come to be accepted as one of the major components of business growth and sustainability. The success in the new economy comes with various challenges. Those challenges require business and their managers to think beyond traditional way of looking for short-term goals. It requires business and the people inside these behemoths to embrace a much broader perspective that is also inclusive of stakeholders. The nature of society we are living in has changed. The nature of governance has equally changed since people are now enjoying more freedom within each societal democratic tenet. This freedom has found its way in the business and into the facto…