Search results for "growth"

showing 10 items of 5134 documents

Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of t…

2009

The biological importance of microtubules in mitosis and cell division makes them an interesting target for the development of anticancer agents. Small molecules such as benzo[b]furans are attractive as inhibitors of tubulin polymerization. Thus, a new class of inhibitors of tubulin polymerization based on the 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b]furan molecular skeleton, with electron-donating (Me, OMe or OH) or electron-withdrawing (F, Cl and Br) substituents on the benzene ring, was synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization and cell cycle effects. Adding a methyl group at the C-3 position resulted in increased activity. The most prom…

structure-activityStereochemistryClinical BiochemistryPharmaceutical ScienceAntineoplastic Agentsmacromolecular substancesBiochemistryChemical synthesisArticleStructure-Activity Relationshipchemistry.chemical_compoundbenzo[b]furansMicrotubuleCell Line TumorFuranDrug DiscoveryHumansStructure–activity relationshipMolecular BiologyBenzofuransCell ProliferationBinding SitesDose-Response Relationship DrugbiologyChemistryTubulin ModulatorsCell growthCell CycleOrganic ChemistrySmall moleculeTubulin Modulatorstubulin polymerizationTubulinDrug Designbiology.proteinMolecular MedicineProtein MultimerizationColchicine
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Teaching is a Story Whose First Pages Matters – Four Type Narratives From The Beginning of a Teaching Career.

2022

From a broad perspective, the entire time spent in teacher training can be characterized as a period of professional growth. Specific professional growth and development are realized when the students enter the advanced stage of master's studies to independently practise their profession in their own class of pupils. The uncertainty of a novice teacher and, on the other hand, the ‘burden of competence’ gained from teacher training make this induction phase very sensitive and critical, as all the competencies they have obtained during teacher training should culminate in this specific phase. The development of a student into an independent teacher is a growth story in which each person's ide…

student supervisionprofessional supportammatillinen kehitysnarratiivinen tutkimuskokemuksetkompetenssicollegialitypeer supportprofessional growthmoniosaaminenopettajatopettajankoulutusammatti-identiteetti
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Sympathoadrenal response to resistance exercise in men, women and pubescent boys : with special reference to interaction with other hormones and neur…

2001

suorituskykyadrenaliininaisetadrenalineliikuntafysiologiastressicortisolhormonitresistance exerciseagetestosteronegrowth hormonegendermiehetpojatvoimaharjoitteluhermostonoradrenaliinihormonaaliset vaikutukset
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Special Functions for the Study of Economic Dynamics: The Case of the Lucas-Uzawa Model

2004

The special functions are intensively used in mathematical physics to solve differential systems. We argue that they should be most useful in economic dynamics, notably in the assessment of the transition dynamics of endogenous growth models. We illustrate our argument on the Lucas-Uzawa model, which we solve by the means of Gaussian hypergeometric functions. We show how the use of Gaussian hypergeometric functions allows for an explicit representation of the equilibrium dynamics of the variables in level. In contrast to the preexisting approaches, our method is global and does not rely on dimension reduction.

symbols.namesakeEndogenous growth theorySpecial functionsDimensionality reductionGaussiansymbolsContrast (statistics)Hypergeometric functionOptimal controlRepresentation (mathematics)Mathematical economicsMathematicsSSRN Electronic Journal
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The Complex WKB Method

2019

In this chapter we shall study the exponential growth and asymptotic expansions of exact solutions of second-order differential equations in the semi-classical limit. As an application, we establish a Bohr-Sommerfeld quantization condition for Schrodinger operators with real-analytic complex-valued potentials.

symbols.namesakeExponential growthDifferential equationQuantization (signal processing)symbolsLimit (mathematics)Schrödinger's catWKB approximationMathematicsMathematical physics
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Business model scaling and growth hacking in digital entrepreneurship

2023

Creating an innovative product and validating an innovative business model may not be enough for digital startups to be competitive. To grow fast and expand globally, digital startups need to innovate their business model during the scaling phase. A pragmatic approach has recently been proposed to support digital entrepreneurs engaging in business-model innovation during the scaling phase (i.e., business-model scaling), a strategy known as growth hacking. However, we know little about its theoretical grounding and how effective growth hacking is, as businesses lack methodologies to assess its effectiveness before committing resources and investments. To fill this gap, we developed a method …

system dynamicSettore SECS-P/07 - Economia AziendaleManagement of Technology and InnovationStrategy and Managementgrowth hackingdigital entrepreneurshipBusiness model innovationGeneral Business Management and AccountingscalabilityJournal of Small Business Management
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A new approach for estimating a nonlinear growth component in multilevel modeling

2011

This study presents a new approach to estimation of a nonlinear growth curve component with fixed and random effects in multilevel modeling. This approach can be used to estimate change in longitudinal data, such as day-of-the-week fluctuation. The motivation of the new approach is to avoid spurious estimates in a random coefficient regression model due to the synchronized periodical effect (e.g., day-of-the-week fluctuation) appearing both in independent and dependent variables. First, the new approach is introduced. Second, a Monte Carlo simulation study is carried out to examine the functioning of the proposed new approach in the case of small sample sizes. Third, the use of the approac…

ta112Social PsychologyComputation05 social sciencesMonte Carlo methodMultilevel model050401 social sciences methods050301 educationRegression analysisRandom effects modelGrowth curve (statistics)EducationNonlinear system0504 sociologyDevelopmental NeuroscienceComponent (UML)Developmental and Educational PsychologyEconometricsApplied mathematicsLife-span and Life-course StudiesPsychology0503 educationta515Social Sciences (miscellaneous)International Journal of Behavioral Development
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Dependency on un-captured GDP as a source of resilience beyond economic value in countries with advanced ICT infrastructure: Similarities and dispari…

2015

Abstract The majority of countries with advanced information and communication technology (ICT) infrastructure have been experiencing extended stagnation due to an “embedded” trap in ICT advancement. However, certain countries have been able to sustain a high level of ICT- driven global competitiveness. This suggests that in these contexts there is resilience beyond economic value. Finland and Singapore can be considered countries of resilience with respect to ICT-driven global competitiveness because of their continued GDP growth despite the recession. While both countries share significant similarities including institutional strength in ICT, they demonstrate noteworthy disparities in the…

ta113Economic efficiencyGovernmentEconomic growthta511Index (economics)Sociology and Political Sciencemedia_common.quotation_subjectGrowth or happinessHuman Factors and ErgonomicsUn-captured GDPRecessionEducationTrap in ICT advancementResilience beyond economic valueInformation and Communications TechnologyDevelopment economicsValue (economics)Finland and Singapore as world ICT leaderHappinessEconomicsPsychological resilienceBusiness and International Managementta512media_commonTechnology in Society
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Co-evolution between Trust in Teachers and Higher Education Enabled by ICT Advancement – A Suggestion to ICT Growing Economies

2016

In light of the increasing significance of trust-based higher education towards digitally-rich learning environments, co-evolution dynamism between trust in teachers and higher education enabled by ICT advancement was analyzed. Using the rate of trust in teachers for good education in the Global Teacher Status Index, together with statistics on higher education level and ICT advancement, an empirical numerical analysis of 20 countries was attempted. It was identified that while ICT advanced countries have constructed a co-evolution between ICT, higher education and trust, ICT growing countries have not succeeded due to a vicious cycle between ICT and trust. Finland’s educational success can…

ta113Index (economics)Knowledge managementHigher educationbusiness.industrysulautuva opetusblended learningPublic relationseducational productivity paradoxlogistic growthBlended learningtrust in teachersInformation and Communications TechnologyPolitical scienceProductivity paradoxComputingMilieux_COMPUTERSANDEDUCATIONta516pedagogical loveDynamismDisengagement theorybusinessJournal of Technology Management for Growing Economies
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Innovation as a driver of internationalization in the software industry

2013

Innovation and internationalization are two important factors for growth. This study analyzes whether innovativeness has an effect on the internationalization of software firms, and if so, how strong this effect is. Innovation and internationalization have rarely been studied together, with research tending to focus more on the relationship between innovations and growth. However, internationalization is a key prerequisite for growth for companies operating in small domestic markets. This paper analyzes the innovativeness and internationalization of firms, using data from the Software Industry Survey conducted in Finland. Since the speed of firm growth and internationalization are dependent…

ta113business.industrysoftware firmsInnovation managementkasvuDomestic marketInternationalizationSoftwareRevenue growthMarketinginternationalizationbusinessIndustrial organizationinnovatiivisuus2013 International Conference on Research and Innovation in Information Systems (ICRIIS)
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