Search results for "hERG"

Les équivalents de traduction dans 'Tintti Afrikassa' et 'Seitsemän kristallipalloa' par rapport aux albums originaux 'Tintin au Congo' et 'Les sept…

2007

Modulation of voltage-gated Na+ and K+ channels by pumiliotoxin 251D: A “joint venture” alkaloid from arthropods and amphibians

2008

Abstract Certain amphibians provide themselves with a chemical defense by accumulating lipophilic alkaloids into skin glands from dietary arthropods. Examples of such alkaloids are pumiliotoxins (PTXs). In general, PTXs are known as positive modulators of voltage-gated sodium channels (VGSCs). Unlike other PTXs, PTX 251D does not share this characteristic. However, mice and insect studies showed that PTX 251D is highly toxic and to date the basis of its toxicity remains unknown. In this work, we searched for the possible target of PTX 251D . The toxin was therefore made synthetically and tested on four VGSCs (mammalian rNa v 1.2/β 1 , rNa v 1.4/β 1 , hNa v 1.5/β 1 and insect Para/tipE ) and…

Einšteina relativitātes teorija līdz E=mc2. Matemātiķa piedzīvojumi. 3.izdevums.

2015

Trešais, uzlabots un papildināts izdevums. Otrais izdevums: https://dspace.lu.lv/dspace/handle/7/1482. Pirmais izdevums: https://dspace.lu.lv/dspace/handle/7/1452

Nonzero |U_e3| from charged lepton corrections and the atmospheric neutrino mixing angle

2013

After the successful determination of the reactor neutrino mixing angle theta(13) not equal 0.16 not equal 0, a new feature suggested by the current neutrino oscillation data is a sizeable deviation of the atmospheric neutrino mixing angle theta(23) from pi/4. Using the fact that the neutrino mixing matrix U = (UeU nu)-U-dagger, where U-e and U-nu result from the diagonalisation of the charged lepton and neutrino mass matrices, and assuming that U-nu has a i) bimaximal (BM), H) tri-bimaximal (TBM) form, or else Hi) corresponds to the conservation of the lepton charge L' = L-e - L mu - L-tau (LC), we investigate quantitatively what are the minimal forms of U-e, in terms of angles and phases …

Sur la fonction des « sphéroïdes » en tôle de l’Age du bronze

2013

La fonction des quatre sphéroïdes en tôle de bronze de France et de Suisse connus, souvent décrits, n’a jamais été établie. En raison de leur mode de façonnage, de leur technique de montage et du style de leur décoration, ils sont rapprochés ici des sphéroïdes italiens qui sont généralement complets. Ces derniers, découverts en général dans des sépultures, étant interprétés comme des encensoirs, il est proposé de considérer comme tels, avec des réserves du fait de leur état fragmentaire, les exemplaires de France et de Suisse. Ces récipients, datés en France du Bronze final IIIb, connaissent en Italie une évolution qui se prolonge jusqu’au début du VIIe s. av. J.-C. Although the four known …

Mode of Action Analyses of Neferine, a Bisbenzylisoquinoline Alkaloid of Lotus (Nelumbo nucifera) against Multidrug-Resistant Tumor Cells

2017

Neferine, a bisbenzylisoquinoline alkaloid isolated from the green seed embryos of Lotus (Nelumbo nucifera Gaertn), has been previously shown to have various anti-cancer effects. In the present study, we evaluated the effect of neferine in terms of P-glycoprotein (P-gp) inhibition via in vitro cytotoxicity assays, R123 uptake assays in drug-resistant cancer cells, in silico molecular docking analysis on human P-gp and in silico absorption, distribution, metabolism, and excretion (ADME), quantitative structure activity relationships (QSAR) and toxicity analyses. Lipinski rule of five were mainly considered for the ADME evaluation and the preset descriptors including number of hydrogen bond d…

Geschichte der Rigaer Stadtbibliothek und deren Bücher

1937

Inhalt: Schriften zur Bibliotheks- und Büchergeschichte. Vorbemerkung des Bearbeiters I. Einführung in die Geschichte der Rigaer Stadtbibliothek und ihre Bestände II. Die mittelalterlichen Bücher der Rigaer Stadtbibliothek III. Neugefundene Bruchstücke des Rigaer niederdeutschen Gesangbuch des aus dem 16. Jahrhundert IV. Drei mittelalterliche Rigaer Handschriften in der Universitätsbibliothek zu Uppsala.