Search results for "hPSC"
showing 3 items of 3 documents
Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy …
2018
Objective The lack of pro-opiomelanocortin (POMC)-derived melanocortin peptides results in hypoadrenalism and severe obesity in both humans and rodents that is treatable with synthetic melanocortins. However, there are significant differences in POMC processing between humans and rodents, and little is known about the relative physiological importance of POMC products in the human brain. The aim of this study was to determine which POMC-derived peptides are present in the human brain, to establish their relative concentrations, and to test if their production is dynamically regulated. Methods We analysed both fresh post-mortem human hypothalamic tissue and hypothalamic neurons derived from …
Musculoskeletal examination in young athletes and non-athletes:the Finnish Health Promoting Sports Club (FHPSC) study
2018
ObjectivesTo determine the inter-rater repeatability of a musculoskeletal examination and to compare findings between adolescent athletes and non-athletes in Finland.MethodsIn this cross-sectional study, a musculoskeletal examination assessing posture, mobility and movement control was carried out by a sports and exercise medicine physician on 399 athletes aged 14–17 years and 177 non-athletes. Within 2 weeks another sports and exercise medicine physician repeated the examination for 41 adolescents to test the inter-rater repeatability.ResultsIn total, 10 of the 11 tests performed had at least moderate inter-rater reliability (κ ≥0.4 or percentage agreement >80%). Athletes more often tha…
Applying health promoting sports club standards in the Netherlands
2014
This study explores health promotion activity of Dutch sports clubs by using the Health Promoting Sports Clubs (HPSC) standards, which are developed in Finland and here applied to the Dutch sports context. The standards consist of 23 items which cover different perspectives on health promotion. The standards form an overall HPSC index, which is used to create health promotion profiles for the sports clubs. 17 sports clubs from the municipality of ‘s-Hertogenbosch participated in this study, of which 42 club officials (1-6 per club) evaluated their own club on all HPSC standards on a five-point Likert scale. Per club, the average score on each standard was calculated. The average on the HPSC…