Search results for "haima"
showing 10 items of 13 documents
Stromal hyaluronan accumulation is associated with low immune response and poor prognosis in pancreatic cancer
2021
AbstractHyaluronan (HA) accumulation has been associated with poor survival in various cancers, but the mechanisms for this phenomenon are still unclear. The aim of this study was to investigate the prognostic significance of stromal HA accumulation and its association with host immune response in pancreatic ductal adenocarcinoma (PDAC). The study material consisted of 101 radically treated patients for PDAC from a single geographical area. HA staining was evaluated using a HA-specific probe, and the patterns of CD3, CD8, CD73 and PD-L1 expression were evaluated using immunohistochemistry. HA staining intensity of tumour stromal areas was assessed digitally using QuPath. CD3- and CD8-based …
Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells
2018
Aims/hypothesis: The Coxsackie and adenovirus receptor (CAR) is a transmembrane cell-adhesion protein that serves as an entry receptor for enteroviruses and may be essential for their ability to infect cells. Since enteroviral infection of beta cells has been implicated as a factor that could contribute to the development of type 1 diabetes, it is often assumed that CAR is displayed on the surface of human beta cells. However, CAR exists as multiple isoforms and it is not known whether all isoforms subserve similar physiological functions. In the present study, we have determined the profile of CAR isoforms present in human beta cells and monitored the subcellular localisation of the princi…
What explains development : development strategy for low human development index countries
2009
Clinical characteristics of pancreatic and biliary tract cancers in Lynch syndrome : A retrospective analysis from the Finnish National Lynch Syndrom…
2023
IntroductionPatients with Lynch syndrome (LS) have an increased lifetime risk of pancreatic cancer (PC) and biliary tract cancer (BTC). These cancers have a notoriously pessimistic prognosis due to late diagnosis and limited therapeutic options. There are limited data based on small cohorts reviewing PC and BTC in LS patients.MethodsIn this retrospective study of the Lynch Syndrome Registry of Finland (LSRFi), records of genetically verified LS patients diagnosed with PC or BTC between 1982 and 2020 were analyzed.ResultsThirty-nine patients were included: tumor(s) were in the pancreas in 26 patients, in the biliary tract in 10, and in the ampulla of Vater in three. A pathogenic germline var…
Prognostic impact of CD73 expression and its relationship to PD-L1 in patients with radically treated pancreatic cancer
2020
AbstractImmune suppressing molecule CD73 is overexpressed in various cancers and associated with poor survival. Little is so far known about the predictive value of CD73 in pancreatic ductal adenocarcinoma (PDAC). The purpose of this study was to investigate the prognostic significance of CD73 in PDAC. The study material consisted of 110 radically treated patients for PDAC. Tissue microarray blocks were constructed and stained immunohistochemically using CD73 antibody. Staining intensity and numbers of stained tumour cells, inflammatory cells, stroma, and blood vessels were assessed. High-level CD73 expression in tumour cells was positively associated with PD-L1 expression, perineural invas…
‘Broken Finnish’ : Speaker L1 and its recognition affecting rating in National Certificates of Language Proficiency test in Finnish
2021
As many European countries have language proficiency requirements for obtaining citizenship, language testing is a possible source of social inequality. The ‘Broken Finnish’ project has been set up to ensure test fairness by addressing the proficiency rating in the National Certificates of Language Proficiency (NCLP) test for Finnish in Finland, with a special focus on perceptions of pronunciation and ‘accent’ in relation to the examinee’s L1 and how the raters recognise them. We explore if and how these perceptions affect the proficiency ratings. We are also interested in studying where the perceptions might arise from. In this paper, we present results from one L1 group: Thai speakers non…
Fecal pancreatic elastase-1 levels in older individuals without known gastrointestinal diseases or diabetes mellitus
2011
Background - Structural changes occur in the pancreas as a part of the natural aging process. With aging, also the incidence of maldigestive symptoms and malnutrition increases, raising the possibility that these might be caused at least in part by inadequate pancreatic enzyme secretion due to degenerative processes and damage of the gland. Fecal elastase-1 is a good marker of pancreatic exocrine secretion. The aim of this study was to investigate the fecal elastase-1 levels among over 60 years old Finnish and Polish healthy individuals without any special diet, known gastrointestinal disease, surgery or diabetes mellitus. Methods - A total of 159 patients participated in this cross-section…
And Thailand still smiles : a study on post-tsunami livelihood recovery of Phuket and Khao Lak
2007
Tutkimuksen tavoitteena on tutkia tapoja, joiden avulla turismiin liittyvät elinkeinot ovat toipuneet tsunamin jälkeen Phuketissa ja Khao Lakissa. Tutkimuksessa etsitään myös piileviä syitä sille, miksi joissakin yhteisöissä elinkeinot ovat toipuneet toisten yhä taistellessa selviytyäkseen tsunamin seurauksista. Tutkimuksen käsitteellinen perusta on elinkeinojen kestävä toipuminen. Erityisen huomion kohteena ovat toipumisen neljä osa-aluetta: maineen, talouden, yhteisöjen ja suhteiden toipuminen. Suhteessa toipumisen osa-alueisiin tutkimuksen tärkeimmiksi asioiksi nousivat tsunamiin liitetyt riskit ja mielikuvat, hallituksen tsunamiapu, kansalaisjärjestöjen rooli erityisesti taitojen kehitt…
"Kirkko ilman musiikkia on kuin riisi ilman lisukkeita" : näkökulmia Thaimaan luterilaisen kirkon virsikirjatyöhön
2000
Elättäjyyttä vai erotiikkaa : miten suomalaiset miehet legitimoivat parisuhteensa thaimaalaisen naisen kanssa?
2005
Hannu Sirkkilä on tutkinut suomalais-thaimaalaisia parisuhteita 18 suomalaisen miehen kertomusten pohjalta. Kyseisten suhteiden syntyyn on liitetty vaimojen välitystoimintaa ja seksiturismia ja ne ovat saaneet kielteisen leiman. Haastatellut miehet haluavatkin tavallistaa thaimaalaisen vaimonsa ja parisuhteensa. Tämä tapahtuu kuvaamalla oma vaimo aktiivisena ja tahtovana naisena eikä alistuvana, kuten thaimaalaiset naiset esitetään stereotyyppisissä käsityksissä. Useilla miehillä on ollut jo ennen suhteen alkua suuri kiinnostus Thaimaata, sen ihmisiä, kulttuuria ja luontoa kohtaan. He puhuvat vältellen aiempiin matkoihin liittyneistä mahdollisista seksiturismikokemuksistaan. Suhteiden alku …