Search results for "harm"

Invasive alien species – potential cheap resources of plant substances for medicinal use

2018

Some alien species demonstrate rather invasive behaviour. They have high tolerance of various habitat conditions and potent propagation ability. They not only over-compete the local vegetation but suppress the seed development of the native plants. In the newly invaded habitats they might not have suitable herbivores to control their populations. The only effective enemy might be Homo sapiens. Humans are known with their destructive power once an object has become significant for industrial utilization. The aim of this study is to review research data and reveal the potential of Ambrosia artemisiifolia L., Erigeron canadensis L., Xanthium strumarium L. and Dittrichia graveolens (L.) W. Greu…

In Vitro Evaluation of Poly(lactide-co-glycolide) In Situ Forming Gels for Bedaquiline Fumarate Salt and Pharmacokinetics Following Subcutaneous Inje…

2021

This study evaluated in vitro and in vivo drug release of bedaquiline from in situ forming gels (ISGs) containing 200 mg eq./g bedaquiline fumarate salt prepared with four different grades of poly(d,l-lactide) (PDLLA) or poly(d,l-lactide-co-glycolide) (PLGA) with a lactide/glycolide ratio of 50/50 or 75/25 and acid (A) or ester (E) end-capping in N-methyl-2-pyrrolidone at a polymer/solvent ratio of 20/80% (w/w). Mean in vitro drug release in 0.05 M phosphate buffer pH 7.4 with 1% (w/v) sodium lauryl sulphate was 37.3, 47.1, 53.3, and 62.3% within 28 days for ISGs containing PLGA5050A, PDLLA, PLGA7525A, and PLGA7525E, respectively. The data suggested that drug release was primarily controlle…

Effect of Information Intervention on Prescribing Practice for Neuropathic Pain in Older Patients : A Nationwide Register-Based Study

2023

Introduction Management of prescription medicines is challenging for older patients due to frail health and the prevalence of multiple chronic conditions. A salient policy challenge of prescribing practices is that all physicians are not well informed about the national clinical guidelines. A feasible policy intervention to mitigate the harms caused by Potentially Inappropriate Medications is to influence the frequency of prescribing and other prescribing attributes of the drugs by providing accurate and up-to-date information about the national clinical guidelines. Objectives The objective of this study was to examine the effect of a nationwide information intervention on physicians’ presc…

Yksittäisen hoitokäynnin tarkastelusta pitkäaikaissairaan vuorovaikutussuhteiden verkoston tarkasteluun

2014

Harmonic sources detection in power systems via nonactive power measurements according to IEEE Std. 1459-2010: theoretical approach and experimental …

2010

In this paper an enhanced decision-making strategy is presented for the detection of harmonic sources in power systems able to detect also which is the prevailing nature of the disturbance (nonlinearity or unbalance). It makes use of some simple indices, which are evaluated by means of the measurements of some nonactive power quantities, proposed by the authors and derived from the approach of the IEEE Std. 1459-2010. The decision-making rules for the proposed strategy are presented and discussed by means of simulation and experimental tests. The results obtained are presented, showing the effectiveness of the proposed strategy for the detection of the dominant harmonic source upstream or d…

DEVELOPMENT & QUALIFICATION OF BIOASSAYS FOR THE DETERMINATION OF THE BIOACTIVITY, PREDICTIVE PHARMACOKINETICS AND POTENTIAL IMMUNOGENICITY OF THERAP…

2021

The critical quality attributes of a given biotherapeutic monoclonal antibody (mAb), its molecular characterization, functional assessment and effector function analysis should be defined and profiled in detail during the life cycle of a biotherapeutic drug. In the past, this product characterization was simple and standardized. In today’s complex world of biologics, success demands a more thoughtful approach and drug developers are investing in advanced analytics much earlier in the development process. Indeed, investing in selected sophisticated and state of the art analytics in early developmental phases of a therapeutic monoclonal antibody may mitigate risks by confirming that the drug …

Clinical characteristics and predictors of death among hospitalized patients infected with SARS‑CoV‑2 in Sicily, Italy: A retrospective observational…

2022

Since late December 2019, severe acute respiratory syndrome coronavirus 2 has spread across the world, which resulted in the World Health Organization declaring a global pandemic. Coronavirus disease 2019 (COVID-19) presents a highly variable spectrum with regard to the severity of illness. Most infected individuals exhibit a mild to moderate illness (81%); however, 14% have a serious disease and 5% develop severe acute respiratory distress syndrome (ARDS), requiring intensive care support. The mortality rate of COVID-19 continues to rise across the world. Data regarding predictors of mortality in patients with COVID 19 are still scarce but are being actively investigated. The present multi…

Pressure support ventilation + sigh in acute hypoxemic respiratory failure patients: Study protocol for a pilot randomized controlled trial, the PROT…

2018

Background Adding cyclic short sustained inflations (sigh) to assisted ventilation yields optimizes lung recruitment, decreases heterogeneity and reduces inspiratory effort in patients with acute hypoxemic respiratory failure (AHRF). These findings suggest that adding sigh to pressure support ventilation (PSV) might decrease the risk of lung injury, shorten weaning and improve clinical outcomes. Thus, we conceived a pilot trial to test the feasibility of adding sigh to PSV (the PROTECTION study). Methods PROTECTION is an international randomized controlled trial that will be conducted in 23 intensive care units (ICUs). Patients with AHRF who have been intubated from 24 h to 7 days and under…

SIA "PHARM & MED" eksporta attīstības iespējas Vācijas tirgū

2019

Mūsdienās pasaule saskaras ar virkni ekonomisko, sociālo, kultūras, demogrāfisko, finansiālo un politisko pārmaiņu vilni, kas krasi ietekmē dzīvesveidu, patēriņa uzvedību un organizāciju vadības procesus. Pēc vietējā tirgus apgūšanas loģisks nākamais solis uzņēmējdarbībā ir eksporta uzsākšana. Lai īstenotu veiksmīgu ieiešanu starptautiskajā tirgū, nepieciešama precīza mārketinga vides analīzes izveide, kas sniedz iespēju uzņēmumam izvērtēt savu potenciālu iekļūšanai vēlamajā tirgū. Diplomdarba tēma ir “SIA “PHARM&MED” EKSPORTA ATTĪSTĪBAS IESPĒJAS VĀCIJAS TIRGŪ”, un tā mērķis ir veikt starptautiskās mārketinga vides izpēti un analīzi, lai spētu izdarīt secinājumus par SIA “Pharm & Med” iespē…

Complex technological and biological research of solutions for peritoneal dialysis

2018

Objective : The purpose of our work was to conduct technological, analytical, and biological investigations and stability studies of peritoneal dialysis (PD) solutions containing glucose and sodium lactate in single-chamber containers. Methods : Different formulations of PD solutions were prepared and sterilized at a temperature of 121 °C during 15 m. UV-spectrophotometric determination was performed using purified water as a blank. The spectra of the solutions were run in the range of 220 to 400 nm for the identification of an absorption maximum (λ max ) and measuring the absorbance at 228-230 nm and λ max before and after heat sterilization. λ max of the most PD solutions after sterilizat…