Search results for "hauraus"

Telomere Length and Frailty: The Helsinki Birth Cohort Study

2018

Objectives: Telomere length is associated with aging-related pathologies. Although the association between telomere length and frailty has been studied previously, only a few studies assessing longitudinal changes in telomere length and frailty exist. Design: Longitudinal cohort study. Setting and participants: A subpopulation of the Helsinki Birth Cohort Study consisting of 1078 older adults aged 67 to 79 years born in Helsinki, Finland, between 1934 and 1944. Measures: Relative leukocyte telomere length (LTL) was measured using quantitative real-time polymerase chain reaction at the average ages of 61 and 71 years, and at the latter the participants were assessed for frailty according to …

Early life determinants of frailty in old age : the Helsinki Birth Cohort Stud

2018

Background there is evidence suggesting that several chronic diseases have their origins in utero and that development taking place during sensitive periods may affect the aging process. We investigated whether early life determinants would be associated with frailty in old age. Methods at a mean age of 71 years, 1,078 participants belonging to the Helsinki Birth Cohort Study were assessed for frailty according to the Fried frailty criteria. Early life measurements (birth weight, length, mother body mass index [BMI] and parity) were obtained from birth, child welfare and school health records. Multinomial regression analysis was used to assess the association between early life determinants…

Retirement age and type as predictors of frailty : a retrospective cohort study of older businessmen

2020

ObjectivesTo study the association between retirement characteristics and frailty in a homogenous population of former business executives.DesignCross-sectional cohort study using data from the Helsinki Businessmen Study.SettingHelsinki, Finland.Participants1324 Caucasian men, born in 1919–1934, who had worked as business executives and managers and of whom 95.9% had retired by the year 2000. Questions on age at and type of retirement, lifestyle and chronic conditions were embedded in questionnaires.Primary and secondary outcome measuresFrailty assessed according to a modified phenotype definition at mean age 73.3 years.ResultsMean age at retirement was 61.3 years (SD 4.3) and 37.1% had ret…

Friction of Shear-Fracture Zones

2017

A shear fracture of brittle solids under compression undergoes a substantial evolution from the initial microcracking to a fully formed powder-filled shear zone. Experiments covering the entire process are relatively easy to conduct, but they are very difficult to investigate in detail. Numerically, the large strain limit has remained a challenge. An efficient simulation model and a custom-made experimental device are employed to test to what extent a shear fracture alone is sufficient to drive material to spontaneous selflubrication. A “weak shear zone” is an important concept in geology, and a large number of explanations, specific for tectonic conditions, have been proposed. We demonstra…

Liikuntaneuvonnan vaikutus ikääntyneiden ihmisten hauraus-raihnausoireyhtymään

2016

Hauraus-raihnausoireyhtymä on geriatrinen syndrooma, joka voi johtaa iäkkään ihmisen toimintakyvyn heikkenemiseen ja lisää sekä laitoshoitoon joutumisen, että kuolleisuuden riskiä. Hauraus-raihnausoireyhtymän ennaltaehkäisyssä ja hoidossa avaintekijänä on iäkkään ihmisen riittävä fyysinen aktiivisuus. Tämän pro gradu –tutkielman tarkoituksena oli selvittää, voidaanko liikuntaneuvonnalla vaikuttaa hauraus-raihnausoireyhtymän fenotyyppiin kuuluviin osatekijöihin, joita ovat hitaus, heikkous, uupumus, vähäinen fyysinen aktiivisuus sekä painon lasku. Lisäksi selvitettiin liikuntaneuvonnan yhteyttä hauraus-raihnausoireyhtymän ilmenemiseen iäkkäillä ihmisillä. Tutkielma on osa Liikuntaneuvonta iä…

Discrete element model for viscoelastic materials with brittle fracture : applications on glacier dynamics

2017

Dietary intake and strength training adaptation in 50-70 -year old men and women : with special reference to muscle mass, strength, serum anabolic ho…

2007

Frailty has been defined as an age-related decrease of the physiologic systems that results in weakness, weight loss and decreased functional performance, thus increasing the risk of disability. The physical characteristics of frailty are affected by the amount of muscle mass and strength. Strength training (ST) can alleviate age-related declines in muscle mass, strength and physical function. However, there is controversy regarding whether dietary intake can improve the effects of ST. The present thesis assessed the effects of dietary intake (DI) on muscular, hormonal and metabolic adaptations to ST in healthy 50-70 year old people. In cross-sectional study I, maximal strength of the leg e…

The utilization of primary healthcare services among frail older adults – findings from the Helsinki Birth Cohort Study

2022

Abstract Background The impact of frailty on primary healthcare service use, especially general practice office visits and remote contacts, is currently unknown. Further, little is known about the association of frailty with physiotherapy contacts. Methods We examined the utilization of primary healthcare services among 1064 participants from the Helsinki Birth Cohort Study between the years 2013 and 2017. Frailty was assessed based on Fried’s frailty criteria at mean age of 71.0 (2.7 SD) years in clinical examinations between the years 2011 and 2013. General practice office visits and remote contacts, the total number of general practice contacts, physiotherapy contacts, and the total numb…