Search results for "head injury"

Low risk of intracranial emergency in patients with minor head injury treated with antiplatelet therapy.

2021

Effect of Torasemide — A New Cl--Transport Inhibitor on Glial Swelling by Lactacidosis and Glutamate

1993

Cytotoxic brain edema, i.e. swelling of glial- and nerve cells is a common result of cerebral ischemia, brain trauma, metabolic disorders, and develops secondarily in vasogenic edema. During ischemia and severe head injury, brain tissue homeostasis is severely changed, and many parameters are simultaneously affected. To dissect and isolate the causal mechanisms leading to swelling of nerve- and glial cells, our laboratory has established an in vitro model [4, 5]. Thereby pathomechanisms can be studied in isolation without interference of epiphenomena taking place in damaged brain tissue under circumstances of cerebral ischemia or trauma. In previous studies the role of acidosis in cell swel…

2019

Background: Recently, the number of refugees in Germany has skyrocketed, leading to a marked increase in refugee children admitted to hospitals. This study describes the special characteristics encountered in pediatric surgical inpatient refugees compared to locally residing patients. Methods: Hospital records of minor refugees admitted to our department from 2005 up to and including 2015 were retrospectively reviewed. Demographic data, diagnoses, comorbidities, body mass indexes, hemoglobin values, and lengths of stay were extracted and statistically compared to local patients. Results: A total of 63 refugee children were analyzed and compared to 24,983 locally residing children. There was…

Biochemical Factors and Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma

1992

A distinction between primary and secondary manifestations of brain damage from acute insults, such as trauma, or ischemia is not only of scientific interest but also of the highest clinical significance. After all, prevention of secondary brain damage in patients with severe head injury or cerebral ischemia is the ultimate purpose of treatment, including the measures of emergency care. It can be assumed that the secondary sequelae of head injury are as important for the outcome as the primary insult is. Therefore, it is obvious that development of more effective forms of treatment requires a better understanding of the mechanisms underlying secondary brain damage. Manifestations of seconda…

Safety and side effects of human and ovine corticotropin-releasing hormone administration in man.

1991

Synthetic human and ovine corticotropin-releasing hormone (hCRH, oCRH) are commonly used as a diagnostic tool of the hypothalamo-pituitary-adrenal axis. In this paper reports about side effects after various modes of CRH-application are analyzed and compared to our corresponding data of human studies with hCRH and oCRH. Generally, CRH is well tolerated after single administration and interval-application of standard doses, although minor side effects appear sometimes after higher doses (greater than 200 micrograms hCRH, oCRH) of CRH-bolus-injections. Predominantly the cardiovascular system (e.g. tachycardia, hypotension, flushing) is affected; neuropsychological symptoms are only seen spora…

Chemoresponsiveness and Breath Physiology in Anosmia

2014

Anosmia is a model to study the interaction among chemoreception systems. In the head injury, the traumatic irreversible anosmia caused by damage to olfactory nerve fibers and brain regions is of enviable research interest. In this study, psychophysiological tests for a comprehensive assessment of olfactory function were utilized to investigate anosmia, together with a new technique based on the breath real-time monitoring of volatile organic compounds (VOCs). We applied the breath and VOCs analysis to investigate chemoresponsiveness in the long-term irreversible post-traumatic anosmia.

Glutamate Enhances Brain Damage from Ischemia and Trauma

1997

The amino acid glutamate is a model agent to demonstrate the significance of neurotoxic mediator compounds in secondary brain damage from trauma, ischemia or other adverse conditions. Intensive research of the role of mediator compounds is clinically worthwile as more specific forms of treatment may emerge for the benefit of afflicted patients. In view of the great number of factors, cytokines, etc., which could play a role, it is mandatory that a mediator function in secondary brain damage is identified according to the stringent requirements established for that purpose. Glutamate has been shown — as is the case for only a few other agents — to meet all the criteria of a mediator of secon…

Lethal rupture of post-traumatic aneurysm of the vertebral artery case report.

2009

Abstract Traumatic aneurysms or dissections of the vertebral artery have been reported in patients who have suffered minor craniofacial injuries in traffic accidents. A case is reported of ruptured traumatic vertebral artery aneurysm due to closed head injury without without penetrating injuries or skull fractures. The macroscopic and histological findings relevant to the vertebral wall were compatible with post-traumatic aneurysm; the rupture of the wall was assumed to be caused by sepsis and local infiltration of inflammatory cells.

Benign paroxysmal positional vertigo as a complication of osteotome expansion of the maxillary alveolar ridge.

2001

Benign paroxysmal positional vertigo (BPPV) is a common vestibular end organ disorder characterized by short, often recurrent episodes of vertigo that are triggered by certain head movements in the plane of the posterior semicircular canals. BPPV may be idiopathic or secondary to a number of underlying conditions such as head injury, viral labyrinthitis, stapes surgery, and chronic suppurative otitis media. 1,2 The most commonly accepted theory postulates the development of BPPV as a result of canalolithiasis, 3 heavy, inorganic particles detached from the otoconial layer by degeneration or head trauma gravitate into the posterior semicircular canal and act as a plunger on the endolymph and…

Stellenwert von Computertomographie und Magnetresonanztomographie in der psychiatrischen Diagnostik

1997

This paper evaluates the role of computed tomography (CT) and magnetic resonance imaging (MRI) in the diagnosis of psychiatric disorders according to the "International Classification of Diseases" (ICD-10). Indications for CT/MRI can be derived from ICD-10 for the identification or exclusion of defined cerebral lesions resp. for the etiology in organic disorders. Due to the lack of specific morphological findings, CT/MRI do not contribute to the classification of all other diagnoses. CT/ MRI can only exclude causal organic factors. However, ICD-10 provides only few guidelines for ruling out cerebral pathology (e.g. tumors in bulimic anorexia). Therefore, recommendations for routine CT/MRI-i…