Search results for "healing"
showing 10 items of 642 documents
Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals
2021
This study proposes a review on hyaluronic acid (HA) known as hyaluronan or hyaluronate and its derivates and their application in cosmetic formulations. HA is a glycosaminoglycan constituted from two disaccharides (N-acetylglucosamine and D-glucuronic acid), isolated initially from the vitreous humour of the eye, and subsequently discovered in different tissues or fluids (especially in the articular cartilage and the synovial fluid). It is ubiquitous in vertebrates, including humans, and it is involved in diverse biological processes, such as cell differentiation, embryological development, inflammation, wound healing, etc. HA has many qualities that recommend it over other substances used…
Skin Immunomodulation during Regeneration: Emerging New Targets
2021
Adipose-Derived Stem Cells (ADSC) are present within the hypodermis and are also expected to play a pivotal role in wound healing, immunomodulation, and rejuvenation activities. They orchestrate, through their exosome, the mechanisms associated to cell differentiation, proliferation, and cell migration by upregulating genes implicated in different functions including skin barrier, immunomodulation, cell proliferation, and epidermal regeneration. ADSCs directly interact with their microenvironment and specifically the immune cells, including macrophages and T and B cells, resulting in differential inflammatory and anti-inflammatory mechanisms impacting, in return, ADSCs microenvironment and …
Hopes and Limits of Adipose-Derived Stem Cells (ADSCs) and Mesenchymal Stem Cells (MSCs) in Wound Healing
2020
Adipose tissue derived stem cells (ADSCs) are mesenchymal stem cells identified within subcutaneous tissue at the base of the hair follicle (dermal papilla cells), in the dermal sheets (dermal sheet cells), in interfollicular dermis, and in the hypodermis tissue. These cells are expected to play a major role in regulating skin regeneration and aging-associated morphologic disgraces and structural deficits. ADSCs are known to proliferate and differentiate into skin cells to repair damaged or dead cells, but also act by an autocrine and paracrine pathway to activate cell regeneration and the healing process. During wound healing, ADSCs have a great ability in migration to be recruited rapidly…
Maladaptive stress coping: An additional psychological factor in the process of chronification of pain or pruritus
2021
Background: Inflammatory skin diseases with chronic pruritus and chronic back pain are very common symptoms in the general population and are associated with a reduced quality of life (QOL). In addition to biological factors, psychosocial reasons are also considered to be responsible for their development. So far, it is not known whether chronic pruritus and chronic back pain are related to maladaptive stress coping. Patients and methods: In our matched pilot case-control study with a total of 259 analyzed subjects, we compared outpatient groups, one suffering from chronic skin diseases with pruritus, the other with chronic back pain, to a healthy control group in terms of their stress copi…
Effect of two distinct implant macro-designs on the osseointegration of bicortically installed implants in two topographic sites. A histomorphometric…
2019
Antecedentes científicos y objetivos de estudio: El uso de implantes dentales como alternativa para la rehabilitación oral ha demostrado su eficacia y mostrando altas tasas de supervivencia. Un aspecto clave de la osteointegración del implante dental está relacionado con la obtención de una estabilidad primaria adecuada, asegurada por el enclavamiento mecánico entre el tejido óseo y la interfaz del implante, la cual depende en parte de la geometría del implante, la rugosidad de la superficie y la técnica quirúrgica para la preparación del lecho implantario. Varios factores están involucrados en la interacción entre la superficie del implante y el hueso nativo circundante durante la osteoint…
Cognitive self-healing system for future mobile networks
2015
This paper introduces a framework and implementation of a cognitive self-healing system for fault detection and compensation in future mobile networks. Performance monitoring for failure identification is based on anomaly analysis, which is a combination of the nearest neighbor anomaly scoring and statistical profiling. Case-based reasoning algorithm is used for cognitive self-healing of the detected faulty cells. Validation environment is Long Term Evolution (LTE) mobile system simulated with Network Simulator 3 (ns-3) [1, 2]. Results demonstrate that cognitive approach is efficient for compensation of cell outages and is capable to improve network coverage. Anomaly analysis can be used fo…
Towards proactive context-aware self-healing for 5G networks
2017
In this paper, we suggest a new research direction and a future vision for Self-Healing (SH) in Self-Organizing Networks (SONs). The problem we wish to solve is that traditional SH solutions may not be sufficient for the future needs of cellular network management because of their reactive nature, i.e., they start recovering after detecting already occurred faults instead of preparing for possible future faults in a pre-emptive manner. The detection delays are especially problematic with regard to the zero latency requirements of 5G networks. To address this problem, existing SONs need to be upgraded from reactive to proactive response. One of the dimensions in SH research is to employ more…
Development of polypeptide-based therapeutics for topical delivery
2019
Topical administration represents the main route to attain local therapeutic activity of bioactive agents in several organs, such as the skin or the heart by means of devices that enhance drug transport through the endothelium acting as a reservoir. The complex structure of the skin protects the human body against potentially harmful external agents; however, this protective mechanism inhibits the penetration of topically administering bioactive agents employed for the treatment of skin diseases. Unfortunately, many of the topical drugs currently used or under evaluation in clinical trials lack the appropriate physico-chemical characteristics required for delivery through the skin. However,…
Confocal laser scanning microscopy for the study of the morphological changes of the postextraction sites
2012
A better understanding of the remodeling process of postextraction sockets is essential in dental treatment planning. The aim of this study was to evaluate whether confocal laser scanning microscopy (CLSM) can be applied to imaging contour changes of postextraction sites, as well as to its quantification with image analysis of obtained three-dimensional images. This work describes a new application of the CLSM technique. The system used was the OLS3100-USS, LEXT model (Olympus((R))). CLSM was used for the surface analysis of the extraction site. The measurements taken with CLSM were: (1) mesio-distal distance, (2) alveolar ridge thickness, and (3) vestibular and lingual alveolar ridge heigh…
Ultraviolet A1 radiation induces nitric oxide synthase-2 expression in human skin endothelial cells in the absence of proinflammatory cytokines.
2001
Skin exposure to ultraviolet radiation from sunlight causes erythema and edema formation as well as inflammatory responses. As some of these ultraviolet-induced effects are potentially mediated by nitric oxide synthases, we examined the role of cytokines and ultraviolet A 1 radiation (340–400 nm) on the expression of the nitric oxide synthase-2 in endothelia of normal human skin biopsies during short-term organ culture as well as expression and activity of the nitric oxide synthase-2 in in vitro cell cultures of human dermal endothelial cells. Both, cytokine challenge (interleukin-1β + tumor necrosis factor-α + interferon-γ) but also ultraviolet A 1 exposure (50 J per cm 2 ) in the absence …