Search results for "hedge"
showing 10 items of 106 documents
Intérêt d'aménagements paysagers pour la biodiversité : exemple d'ingénierie agroécologique sur le domaine expérimental d'Epoisses (Inra Dijon)
2013
The biodiversity conservation is one of the major agricultural issues of the XXIst century. The intensification of agriculture and the redesign of the agricultural landscape (grouping of fields, …) lead to huge decreases or damages of semi-naturals habitats, known to promote biodiversity at the farm and the landscape scale, and now recognised as “topographic surface equivalence” in France.In the experimental site of Epoisses (INRA of Dijon), a study to design the landscape elements in favour of the biodiversity has been initiated. Improving the management of existing habitats (woods, hedges, ditches, sown grass margin strips), establishing hedges, flower strips, redesigning the field organi…
Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain
2008
AbstractIFT172, also known as Selective Lim-domain Binding protein (SLB), is a component of the intraflagellar transport (IFT) complex. In order to evaluate the biological role of the Ift172 gene, we generated a loss-of-function mutation in the mouse. The resulting Slb mutant embryos die between E12.5 and 13.0, and exhibit severe cranio-facial malformations, failure to close the cranial neural tube, holoprosencephaly, heart edema and extensive hemorrhages. Cilia outgrowth in cells of the neuroepithelium is initiated but the axonemes are severely truncated and do not contain visible microtubules. Morphological and molecular analyses revealed a global brain-patterning defect along the dorsal–…
Sonic hedgehog promotes the migration and proliferation of optic nerve oligodendrocyte precursors.
2007
Optic nerve (ON) oligodendrocyte precursors (OPCs) are generated under the influence of the Sonic hedgehog (Shh) in the preoptic area from where they migrate to colonise the entire nerve. The molecular events that control this migration are still poorly understood. Recent studies suggested that Shh is often used by the same cell population to control different processes, including cell proliferation and migration, raising the possibility that Shh could contribute to these aspects of OPC development. In support of this idea, we show here that Shh induces the proliferation of OPCs derived from embryonic mouse ON explants and acts as a chemoattractant for their migration. In ovo injections of …
Méthode d'analyse des haies : Protocole d'observation et gestion informatisée des données
1995
Subvention 93/182 "Organisation paysagère, agricole, écologique, sociale des structures linéaires boisées" Programme "Field boundary habitats for wildlife, crop and environmental protection"; Méthode d'analyse des haies : Protocole d'observation et gestion informatisée des données
Primary Analysis of Phase 2 Results for Cemiplimab in Patients (pts) with Locally Advanced Basal Cell Carcinoma (laBCC) who Progress on or are Intole…
2021
Abstract not available.
GSK-3 as potential target for therapeutic intervention in cancer
2014
// James A. McCubrey 1 , Linda S. Steelman 1 , Fred E. Bertrand 2 , Nicole M. Davis 1 , Melissa Sokolosky 1 , Steve L. Abrams 1 , Giuseppe Montalto 3 , Antonino B. D’Assoro 4 , Massimo Libra 5 , Ferdinando Nicoletti 5 , Roberta Maestro 6 , Jorg Basecke 7,8 , Dariusz Rakus 9 , Agnieszka Gizak 9 Zoya Demidenko 10 , Lucio Cocco 11 , Alberto M. Martelli 11 and Melchiorre Cervello 12 1 Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University Greenville, NC, USA 2 Department of Oncology, Brody School of Medicine at East Carolina University Greenville, NC, USA 3 Biomedical Department of Internal Medicine and Specialties, University of Palermo, Palermo, Italy …
The hedgehog receptor patched is involved in cholesterol transport.
2011
International audience; BACKGROUND: Sonic hedgehog (Shh) signaling plays a crucial role in growth and patterning during embryonic development, and also in stem cell maintenance and tissue regeneration in adults. Aberrant Shh pathway activation is involved in the development of many tumors, and one of the most affected Shh signaling steps found in these tumors is the regulation of the signaling receptor Smoothened by the Shh receptor Patched. In the present work, we investigated Patched activity and the mechanism by which Patched inhibits Smoothened. METHODOLOGY/PRINCIPAL FINDINGS: Using the well-known Shh-responding cell line of mouse fibroblasts NIH 3T3, we first observed that enhancement …
Zebrafish Fins as a Model System for Skeletal Human Studies
2007
Recent studies on the morphogenesis of the fins ofDanio rerio(zebrafish) during development and regeneration suggest that a number of inductive signals involved in the process are similar to some of those that affect bone and cartilage differentiation in mammals and humans. Akimenko et al. (2002) has shown that bone morphogenetic protein-2b (BMP2b) is involved in the induction of dermal bone differentiation during fin regeneration. Many other groups have also shown that molecules from the transforming growth factor-beta superfamily (TGFβ), including BMP2, are effective in promoting chondrogenesis and osteogenesisin vivoin higher vertebrates, including humans. In the present study, we review…
Topography of somatostatin gene expression relative to molecular progenitor domains during ontogeny of the mouse hypothalamus
2010
The hypothalamus comprises alar, basal, and floor plate developmental compartments. Recent molecular data support a rostrocaudal subdivision into rostral (terminal) and caudal (peduncular) halves. In this context, the distribution of neuronal populations expressing somatostatin (Sst) mRNA was analyzed in the developing mouse hypothalamus, comparing with the expression pattern of the genes Orthopedia (Otp), Distal-less 5 (Dlx5), Sonic Hedgehog (Shh), and Nk2 homeobox 1 (Nkx2.1). At embryonic day 10.5 (E10.5), Sst mRNA was first detectable in the anterobasal nucleus, a Nkx2.1-, Shh-, and Otp-positive basal domain. By E13.5, nascent Sst expression was also related to two additional Otp-positiv…
The impact of financial crises on co-movements between commodity futures and equity prices : evidence from crude oil and gold markets
2017
Omaisuusluokkien välisillä korrelaatioilla on tärkeä rooli sijoitussalkun hajautusta ajatellen. Omaisuuslajien suojauksen kannalta erityisen tärkeää on tutkia, miten eri omaisuusluokat korreloivat kriisiperiodien aikana. Tässä Pro-Gradu -tutkielmassa tarkastellaan osakemarkkinakriisien vaikutusta hyödykefutuurien ja osakemarkkinatuottojen välisiin korrelaatioihin USA:n markkinoilla erityisesti raakaöljyn ja kullan osalta. Korrelaatioiden mallintamisessa hyödynnetään Cappiellon, Englen ja Sheppardin vuonna 2006 ehdottamaa yleistettyä diagonaalimuotoista DCC GARCH -mallia. Tutkimuksessa verrataan ehdollisten korrelaatioiden kehitystä erikseen USA:n osakemarkkinoiden yleisindeksin ja energiase…