Search results for "helium"

showing 10 items of 1689 documents

Effects of clopidogrel, prasugrel and ticagrelor on endothelial function, inflammatory and oxidative stress parameters and platelet function in patie…

2014

Introduction Particularly in the setting of acute coronary syndromes, the interplay between vascular and platelet function has been postulated to have direct clinical implications. The present trial is designed to test the effect of clopidogrel, prasugrel and ticagrelor on multiple parameters of vascular function, platelet aggregation, oxidative and inflammatory stress before and up to 4 weeks after coronary artery stenting. Methods and analysis The study is designed as a three-arm, parallel design, randomised, investigator-blinded study. Patients with unstable angina or non-ST elevation myocardial infarction undergoing coronary intervention with a drug-eluting stent will be randomised to r…

1683AdultBlood PlateletsMaleTicagrelorAdenosineTiclopidineAdolescent610 MedizinCardiovascular MedicineYoung AdultPercutaneous Coronary Intervention610 Medical sciencesProtocolHumansSingle-Blind Method1506Prospective StudiesAcute Coronary Syndrome1707AgedDrug-Eluting StentsMiddle AgedClopidogrelOxidative StressTreatment OutcomePurinergic P2Y Receptor AntagonistsFemaleEndothelium VascularPrasugrel HydrochloridePlatelet Aggregation InhibitorsFollow-Up Studies
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Cardiometabolic Alterations in the Interplay of COVID-19 and Diabetes: Current Knowledge and Future Avenues

2021

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease 2019 [COVID-19]) pandemic has raged for almost two years, with few signs of a sustained abatement or remission [...]

2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)QH301-705.5virusesSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)CatalysisDiabetes ComplicationsInorganic ChemistryDiabetes mellitusPandemicmedicineHumansBiology (General)Physical and Theoretical ChemistryQD1-999Molecular BiologySpectroscopySARS-CoV-2business.industryOrganic ChemistryCOVID-19virus diseasesGeneral Medicinemedicine.diseaseComputer Science ApplicationsLipoproteins LDLChemistryn/aEditorialCardiovascular DiseasesImmunologyCOVID-19 Cardiovascular Diseases Diabetes Complications Endothelium Vascular Humans Lipoproteins LDL SARS-CoV-2Endothelium VascularbusinessInternational Journal of Molecular Sciences
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Thermomineral waters of Greece: geochemical characterization

2020

75 °C). In terms of pH most results vary from 5.5 to 823 °C) ii) warm (23 40 °C) iii) thermal (40 75 °C) and iv) hyperthermal (&gtfew springs show either very low pH (&lt10) proposing serpentinization processes. Regarding TDS concentrations collected waters can be subdivided into low salinity (up to 1.5 g/L) brackish (up to 20 g/L) and saline (up to 43 g/L). The medium high salinities can be justified by mixing with sea water and/or strong waterrock interaction processes. Isotope composition of O and H ranges from 12.7 to +2.7 ‰ SMOW and from 91 to +12 ‰ SMOW respectively and is generally comprised between the Global Meteoric Water Line and the East Mediterranean Meteoric Water Line. Only few water samples show a positive shift for δ18O possibly related to high temperature waterrock interaction processes. Carbon dioxide (18 997000 μmol/mol) or N2 (1100 989000 μmol/mol) or CH4 (&ltMany geothermal areas of Greece are located in regions affected by Miocene or Quaternary volcanism and in continental basins characterised by elevated heat flow. Moreover the majority of them is found along the coast as well as in islands of the Aegean Sea and thus thermal water is often brackish to saline due to marine intrusion into costal aquifer. In the present study almost 300 thermal and cold mineral water samples were collected along the Hellenic territory with their physicochemical parameters (temperature pH electrical conductivity and Eh) and the amount of bicarbonates (titration with 0.1N HCl) being determined in situ. Additionally gases found either in free or dissolved phase were sampled. Both water and gas samples were analysed at the INGVPa laboratories for major ions (Ion Chromatography) silica (Inductively Coupled Plasma Optical Emission Spectrometry) chemical composition of free and dissolved gases (Gas Chromatography) water isotopes (O and H) and carbon and helium isotopes of free and dissolved gases (Mass Spectrometry). The temperature of the investigated waters ranges from 6.5 to 98°C pH from 1.96 to 11.98 whilst Total Dissolved Solids (TDS) from 0.06 to 43 g/L. Based on the temperature parameter waters can be divided into four groups: i) cold (&lt0.5 913000 μmol/mol) are the prevailing gas species found in the studied sites. The δ13CCO2 values ranged from 20.1 to +8.5 ‰ whilst the isotope ratio of He from 0.21 to 6.71 R/RA.4) suggesting interaction with H2Srich gases or very high pH values (&gtSettore GEO/08 - Geochimica E Vulcanologia
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Revised rates for the stellar triple-alpha process from measurement of C-12 nuclear resonances

2005

4 pages, 3 figures.-- PMID: 15650733 [PubMed].

ASTROPHYSICSchemistry.chemical_elementAstrophysics7. Clean energy01 natural sciencesTriple-alpha processNuclear physicsNucleosynthesis0103 physical sciencesELEMENTSPARTICLESBETA-DECAY010303 astronomy & astrophysicsHeliumPhysicsNUCLEOSYNTHESISMultidisciplinary010308 nuclear & particles physicsB-12Carbon-12Cell BiologyAlpha particleStarsSupernovachemistry13. Climate actionExcited stateSTARS
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Angiotensin II dependent cardiac remodeling in the eel Anguilla anguilla involves the NOS/NO system

2017

Angiotensin II (AngII), the principal effector of the Renin-Angiotensin System (RAS), plays an important role in controlling mammalian cardiac morpho-functional remodelling. In the eel Anguilla anguilla, one month administration of AngII improves cardiac performance and influences the expression and localization of molecules which regulate cell growth. To deeper investigate the morpho-functional chronic influences of AngII on the eel heart and the molecular mechanisms involved, freshwater eels (A. anguilla) were intraperitoneally injected for 2 months with AngII (1 nmol g BW-1). Then the isolated hearts were subjected to morphological and western blotting analyses, and nitrite measurements.…

AT(2) receptor; ERK(1-2); Hsp90; Myocardial growth; NOSTRIN0301 basic medicineMAPK/ERK pathwayCancer ResearchPhysiologyClinical Biochemistry030204 cardiovascular system & hematologyBiochemistrychemistry.chemical_compound0302 clinical medicineEnosMyocardial growthReceptorMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Receptors AngiotensinVentricular RemodelingAngiotensin IIHeartNitric oxide synthaseERKmedicine.anatomical_structurecardiovascular systemCollagenmedicine.medical_specialtyEndotheliumHeart VentriclesHsp90BiologyNitric OxideNitric oxide03 medical and health sciencesInternal medicinemedicineAnimalsHSP90 Heat-Shock ProteinsVentricular remodelingAT receptorNitritesERK(1-2)Anguillamedicine.diseasebiology.organism_classificationNOSTRINAngiotensin II030104 developmental biologyEndocrinologychemistryAT(2) receptorbiology.proteinNitric Oxide SynthaseProto-Oncogene Proteins c-akt
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H-He collision-induced satellite in the Lyman alpha profile of DBA white dwarf stars

2020

The spectra of helium-dominated white dwarf stars with hydrogen in their atmosphere present a distinctive broad feature centered around 1160~\AA\/ in the blue wing of the Lyman-$\alpha$ line. It is extremely apparent in WD 1425+540 recently observed with HST COS. With new theoretical line profiles based on ab initio atomic interaction potentials we show that this feature is a signature of a collision-induced satellite due to an asymptotically forbidden transition. This quasi-molecular spectral satellite is crucial to understanding the asymmetrical shape of Lyman-$\alpha$ seen in this and other white dwarf spectra. Our previous work predicting this absorption feature was limited by molecular…

ATOMIC DATALINE: PROFILEAb initiochemistry.chemical_elementBASIS-SETLINEEXCITED-STATEAstrophysics::Cosmology and Extragalactic Astrophysics01 natural sciencesSpectral linePhysics - Atomic PhysicsWHITE DWARF0103 physical sciencesRadiative transferABSORPTIONAstrophysics::Solar and Stellar AstrophysicsAB-INITIO CALCULATIONPhysics::Atomic PhysicsELECTRONIC-TRANSITION MOMENT010306 general physicsSTARS: ATMOSPHERE010303 astronomy & astrophysicsHeliumLine (formation)POTENTIAL-ENERGY CURVEPhysics[PHYS]Physics [physics]BALMER-ALPHAWhite dwarfAstronomy and AstrophysicsMOLECULAR DATAPotential energyDipolechemistryAstrophysics - Solar and Stellar AstrophysicsSpace and Planetary ScienceATOMIC PROCESSSHAPE[PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph]Atomic physics[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
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Effects of high pressure thermal treatments in oxygen and helium atmospheres on amorphous silicon dioxide and its radiation hardness

2009

The effects of thermal treatments at similar to 400 degrees C in oxygen or helium atmospheres at similar to 180 baron the radiation hardness of amorphous SiO(2) are studied. The generation efficiency of several point defects under gamma irradiation is compared to that of the untreated material. All the effects on point defects generation here observed can be explained in terms of changes in the precursor sites. In particular it has been observed that the thermal treatments can change the precursors sites of point defects both through temperature and pressure related processes, not depending on the atmosphere, and through oxygen related processes creating oxygen excess sites. The presence of…

Absorption spectroscopyHydrogenirradiation effectsSettore FIS/01 - Fisica SperimentaleAnalytical chemistrychemistry.chemical_elementsistemi amorfi difetti di puntoCondensed Matter PhysicsOxygenCrystallographic defectElectronic Optical and Magnetic MaterialsAmorphous solidAtmospherechemistryChemical engineeringMaterials ChemistryCeramics and CompositesLuminescenceHelium
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WNT2 activation through proximal germline deletion predisposes to small intestinal neuroendocrine tumors and intestinal adenocarcinomas

2021

Abstract Many hereditary cancer syndromes are associated with an increased risk of small and large intestinal adenocarcinomas. However, conditions bearing a high risk to both adenocarcinomas and neuroendocrine tumors are yet to be described. We studied a family with 16 individuals in four generations affected by a wide spectrum of intestinal tumors, including hyperplastic polyps, adenomas, small intestinal neuroendocrine tumors, and colorectal and small intestinal adenocarcinomas. To assess the genetic susceptibility and understand the novel phenotype, we utilized multiple molecular methods, including whole genome sequencing, RNA sequencing, single cell sequencing, RNA in situ hybridization…

AdenomaAcademicSubjects/SCI01140DOMAINSadenokarsinoomaCANCER-RISKIn situ hybridizationsuolistosyövätAdenocarcinomaBiologyNeuroendocrine tumorsGermlineWnt2 Proteinperinnöllinen alttius03 medical and health sciences0302 clinical medicineWNT2GeneticsGenetic predispositionmedicineHumansIntestinal MucosaMUTATIONMolecular BiologyGenetics (clinical)030304 developmental biologypaksusuolisyöpäCARCINOID-TUMORS0303 health sciencesperinnölliset tauditCYSTIC-FIBROSISGeneral MedicineNATIONWIDEmedicine.diseaseIntestinal epithelium3. Good healthGENOMENeuroendocrine TumorsHyperplastic PolypSingle cell sequencing3121 General medicine internal medicine and other clinical medicine030220 oncology & carcinogenesisMAPCancer researchsyöpätaudit3111 BiomedicineGeneral Articlegeneettiset tekijätColorectal Neoplasms
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Expression of glial filament protein (GFP) in nerve sheaths and non-neural cells re-examined using monoclonal antibodies, with special emphasis on th…

1986

We describe two novel monoclonal antibodies specific for glial filament protein (GFP), i.e., GF12.23 and GF12.24 (both IgG2a]. These cross-react over a broad range of species with epitopes located in the alpha-helical rod domain typical of all intermediate filament (IF) proteins. These monoclonal antibodies were used, in conjunction with other monoclonal GFP antibodies, rabbit antiserum to GFP, and various antibodies to other cytoskeletal proteins, to examine the occurrence of GFP in cells outside of the central nervous system of rodents, cows, and humans. We detected some scattered GFP-containing cells in the neural sheaths in some species but not in others, and we obtained different resul…

AdenomaCancer Researchmedicine.drug_classGuinea PigsAdenoma PleomorphicFluorescent Antibody TechniqueCross ReactionsMonoclonal antibodyEyeEpitopeEpitheliumSalivary GlandsGreen fluorescent proteinEpitopesSpecies SpecificityGlial Fibrillary Acidic ProteinmedicineAnimalsHumansVimentinIntermediate filamentMolecular BiologyMyelin SheathbiologyMyoepithelial cellAntibodies MonoclonalCell BiologyMolecular biologyRatsMicroscopy FluorescenceMonoclonalImmunologybiology.proteinHepatic stellate cellKeratinsCattleAntibodyDevelopmental BiologyDifferentiation; research in biological diversity
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Gastric adenomas: relationship between clinicopathological findings, Helicobacter pylori infection, APC mutations and COX-2 expression.

2006

Gastric adenomas are rare neoplastic growths characterized by localized polypoid proliferations of dysplastic epithelium that tend to progress to infiltrating adenocarcinoma. Therefore, the identification of molecular markers that could reliably recognize adenomas at risk of progression is advocated in the clinical management. In this study we investigated, in a series of gastric adenoma specimens from an area at high risk of gastric cancer, the relationship between clinicopathological characteristics of adenoma and Helicobacter pylori infection, APC mutational status, and COX-2 and the down-stream enzyme mPGES1 expression. Helicobacter pylori infection, detected in 24%, and 33% by histolog…

AdenomaMaleGenes APCAdenomaAdenocarcinomamedicine.disease_causegastric adenomaHelicobacter InfectionsHelicobacter pyloryStomach NeoplasmsmedicineHumansAPC mutationsAgedProstaglandin-E SynthasesAged 80 and overMutationbiologyHelicobacter pyloribusiness.industryCancerAPC mutations; COX-2; gastric adenoma; Helicobacter pyloriHistologyHematologyHelicobacter pyloriCOX-2Middle Agedmedicine.diseasebiology.organism_classificationdigestive system diseasesEpitheliumIntramolecular Oxidoreductasesmedicine.anatomical_structureOncologyDysplasiacyclooxygenase-2Cyclooxygenase 2Gastric MucosaMutationCancer researchAPC-mutations gastric adenoma Helycobacter pyloriAdenocarcinomaFemalebusiness
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