Search results for "hepatic"
showing 9 items of 609 documents
Isolation and characterization of microsatellite markers in the liver fluke (Fasciola hepatica)
2004
PRIMER NOTE; International audience; Six microsatellite markers were isolated from Fasciola hepatica, a re-emerging parasite that causes important veterinary and public health problems. In a sample of 52 liver flukes from a region of hyperendemicity (Bolivian Altiplano), five microsatellite were polymorphic. Our results showed that liver flukes present important genetic variability, suggesting a preferential outcrossing reproduction mode for this hermaphroditic parasite.
Phenotypic and genetic characterization of emerging trematodiasis: Fascioliasis and Schistosomiasis
2021
La Fascioliasis y la Esquistosomiasis son dos importantes trematodiasis (re)emergentes con gran impacto en la salud humana. Dada la necesidad de caracterizar las poblaciones de Trematodos involucradas, los objetivos de la presente investigación son: en primer lugar, analizar el impacto de la reinfección experimental por Fasciola hepatica en los fenotipos inmunológicos, clínicos y biológicos por medio de un diseño experimental que reproduce las condiciones habituales de reinfección/cronicidad en las zonas endémicas de la Fascioliasis humana; en segundo lugar, la caracterización fenotípica morfológica de huevos de Schistosoma haematobium de migrantes subsaharianos con Esquistosomiasis urogeni…
Estudio experimental comparado de marcadores bioquímicos en la infección por Fasciola hepatica y F. gigantica
2017
Fascioliasis is caused by the genetically and phenotypically very close Fasciola hepatica and F. gigantica. The latter, always considered secondary in human infection, appears nowadays increasingly involved in human endemic areas of Africa and Asia. Unfortunately, little is known about the pathogenicity of this liver fluke species, mainly due to difficulties assessing the moment of a patient's infection in the anamnesis and in the differential diagnosis with F. hepatica. This is the first experimental study comparing F. hepatica and F. gigantica in a long-term study of up to 24 weeks with genotypically and phenotypically standardised fluke strains in the same animal model host, the Guirra s…
The rs2294918 E434K variant modulates PNPLA3 expression and liver damage.
2015
The PNPLA3 rs738409 polymorphism (I148M) is a major determinant of hepatic fat and predisposes to the full spectrum of liver damage in nonalcoholic fatty liver disease (NAFLD). Aim of this study was to evaluate whether additional PNPLA3 coding variants contribute to NAFLD susceptibility, first in individuals with contrasting phenotypes (with early onset NAFLD vs. very low aminotransferases), and then in a large validation cohort. Rare PNPLA3 variants were not detected by sequencing coding regions and intron-exon boundaries either in 142 patients with early-onset NAFLD, nor in 100 healthy individuals with ALT A polymorphism (E434K sequence variant) was over-represented in NAFLD (adjusted p=0…
Estudios estratégicos para la lucha contra la fascioliasis humana a nivel mundial = Strategic studies for the fight against de human fascioliasis wor…
2013
Fascioliasis is a zoonotic parasitic disease caused by Fasciola hepatica and F. gigantica. Emergence of human fascioliasis prompted a worldwide control initiative including a pilot study in several countries. Given the necessity to characterize the fasciolid populations involved, the overall aim of the present research is, first, the phenotypic characterization of faciolid adults and eggs implicated in human endemic areas, where this initiative has been implemented, through a computer image analysis system (CIAS) applied on the basis of standardized measurements. Second, new immunological techniques and their potential use as immunological diagnostic tests in those areas are evaluated. The …
A single transient episode of hyperammonemia induces long-lasting alterations in protein kinase A.
2007
A single transient episode of hyperammonemia induces long-lasting alterations in protein kinase A. Am J Physiol Gastrointest Liver Physiol 292: G305-G314,2007; doi:10.1152/ajpgi.00100.2006.-Hepatic encephalopathy in patients with liver disease is associated with poor prognosis. This could be due to the induction by the transient episode of hepatic encephalopathy of long-lasting alterations making patients more susceptible. We show that a single transient episode of hyperammonemia induces long-lasting alterations in signal transduction. The content of the regulatory subunit of the protein kinase dependent on cAMP (PKA-RI) is increased in erythrocytes from cirrhotic patients. This increase is…
Characterization and evaluation of hepatic differentiation potential of human umbilical cord mesenchymal stem cells
2012
Survival trends for primary liver cancer, 1995–2009: analysis of individual data for 578,740 patients from 187 population-based registries in 36 coun…
2019
CONCORD Working Group Members: Africa—Algeria: S Bouzbid (Registre du Cancer d’Annaba); M Hamdi-Chérif*, Z Zaidi (Registre du Cancer de Sétif); Gambia: R Swaminathan (National Cancer Registry); Lesotho: SH Nortje (Children’s Haematology Oncology Clinics - Lesotho); Libya: MM El Mistiri (Benghazi Cancer Registry); Mali: S Bayo, B Malle (Kankou Moussa University); Mauritius: SS Manraj, R Sewpaul-Sungkur (Mauritius National Cancer Registry); Nigeria: A Fabowale, OJ Ogunbiyi* (Ibadan Cancer Registry); South Africa: D Bradshaw, NIM Somdyala (Eastern Cape Province Cancer Registry); DC Stefan (Umtata University); Tunisia: L Jaidane, M Mokni (Registre du Cancer du Centre Tunisien). America (Central…
Real-world experience with obeticholic acid in patients with primary biliary cholangitis
2021
Background & aims Obeticholic acid (OCA) is the second-line treatment approved for patients with primary biliary cholangitis (PBC) and an inadequate response or intolerance to ursodeoxycholic acid. We aimed to evaluate the effectiveness and safety of OCA under real-world conditions. Methods Patients were recruited into the Italian PBC Registry, a multicentre, observational cohort study that monitors patients with PBC at national level. The primary endpoint was the biochemical response according to Poise criteria; the secondary endpoint was the biochemical response according to normal range criteria, defined as normal levels of bilirubin, alkaline phosphatase (ALP), and alanine aminotransfer…