Search results for "heterogeneous"

Antimicrobial Activity Characterization in a Heterogeneous Group of Compounds

1998

In this work we carry out a study of pattern recognition to detect the microbiological activity in a group of heterogeneous compounds. The structural descriptors utilized are the topological connectivity indexes. The methods followed are stepwise linear discriminant analysis (linear analysis) and artificial neural network (nonlinear analysis). Although both methods are appropriate to differentiate between active and inactive compounds, the artificial neural network is, in this case, more adequate, since it shows in a test set a prediction success of 98%, versus 92% obtained with linear discriminant analysis.

Polyphenols: Bioaccessibility and bioavailability of bioactive components

2019

Abstract Plant phenolics consist of a heterogeneous group of chemical species naturally present in vegetables and commonly alleged to display health benefits. In modern times, the consumption of processed food is increasing within several populations along with the demand for food of enhanced characteristics, such as those including bioactive compounds (e.g., phenolic compounds). On one hand, thermal processing, widely used to increase food safety, has deep impacts on bioaccessibility and bioavailability of bioactive components. On the other hand, non-thermal technologies are interesting alternatives, but additional studies are necessary to understand the biochemistry fundamentals and hence…

Activation of oligodendroglial Fyn kinase enhances translation of mRNAs transported in hnRNP A2-dependent RNA granules.

2008

Central nervous system myelination requires the synthesis of large amounts of myelin basic protein (MBP) at the axon–glia contact site. MBP messenger RNA (mRNA) is transported in RNA granules to oligodendroglial processes in a translationally silenced state. This process is regulated by the trans-acting factor heterogeneous nuclear ribonucleoprotein (hnRNP) A2 binding to the cis-acting A2 response element (A2RE). Release of this repression of MBP mRNA translation is thus essential for myelination. Mice deficient in the Src family tyrosine kinase Fyn are hypomyelinated and contain reduced levels of MBP. Here, we identify hnRNP A2 as a target of activated Fyn in oligodendrocytes. We show that…

Heterogeneous nuclear ribonucleoprotein (hnRNP) F is a novel component of oligodendroglial RNA transport granules contributing to regulation of myeli…

2011

Myelin basic protein (MBP) is a major component of central nervous system (CNS) myelin. The absence of MBP results in the loss of almost all compact myelin in the CNS. MBP mRNA is sorted into RNA granules that are transported to the periphery of oligodendrocytes in a translationally inactive state. A central mediator of this transport process is the trans-acting factor heterogeneous nuclear ribonucleoprotein (hnRNP) A2 that binds to the cis-acting A2-response element in the 3′UTR of MBP mRNA. Recently, we found that activation of the Src family nonreceptor tyrosine kinase Fyn in oligodendrocytes leads to phosphorylation of hnRNP A2 and to increased translation of MBP mRNA. Here, we identify…

Identification in the rat brain of a set of nuclear proteins interacting with H1° mRNA

2012

Synthesis of H1° histone, in the developing rat brain, is also regulated at post-transcriptional level. Regulation of RNA metabolism depends on a series of RNA-binding proteins (RBPs); therefore, we searched for H1° mRNA-interacting proteins. With this aim, we used in vitro transcribed, biotinylated H1° RNA as bait to isolate, by a chromatographic approach, proteins which interact with this mRNA, in the nuclei of brain cells. Abundant RBPs, such as heterogeneous nuclear ribonucleoprotein (hnRNP) K and hnRNP A1, and molecular chaperones (heat shock cognate 70, Hsc70) were identified by mass spectrometry. Western blot analysis also revealed the presence of cold shock domain-containing protein…

Degradation of 4-nitrophenol (4-NP) using Fe-TiO2 as a heterogeneous photo-Fenton catalyst

2010

Heterogeneous photocatalysis for selective partial oxidation reactions in aqueous suspension

2018

Heterogeneous photocatalysis for selective partial oxidation reactions in aqueous suspension

Avoiding Boundary Effects in Wang-Landau Sampling

2003

A simple modification of the ``Wang-Landau sampling'' algorithm removes the systematic error that occurs at the boundary of the range of energy over which the random walk takes place in the original algorithm.

Propiedades psicométricas del Inventario Breve de Síntomas-18 en una muestra heterogénea de pacientes de cáncer adulto

2019

espanolResumen El Inventario Breve de Sintomas-18 (BSI-18) es un instrumento de cribado ampliamente utilizado para evaluar distres emocional (GSI) y tres tipos de sintomas: ansiedad, depresion, y somatizacion. Este trabajo estudia la estructura factorial del BSI-18, utilizando analisis factorial confirmatorio (AFC), su fiabilidad y validez convergente, asi como su invarianza factorial a traves del sexo. Una muestra de 1183 pacientes de cancer completo el BSI 18 y la lista de problemas de la NCCN. Los modelos jerarquicos de tres y cuatro factores proporcionaron ajustes adecuados y similares. Sin embargo, el modelo de tres factores (propuesta teorica) fue seleccionado por razones metodologica…

Beerkan Estimation of Soil Transfer parameters (BEST) across soils and scales

2019

Abstract Theories and models used in soil hydrological sciences rely on the knowledge of the spatially and temporally variable soil hydraulic properties, i.e. the water retention and hydraulic conductivity curves. Obtaining reliable experimental information on these curves for an area of interest is not easy and it still remains a challenge for soil scientists. In 2006, a simple and physically based methodology was proposed to completely characterize the soil using a single ring infiltration experiment in the field and determination of soil particle size distribution, initial and final soil water content and dry soil bulk density. This methodology, named BEST – Beerkan Estimation of Soil Tr…