Search results for "hierarchy"
showing 10 items of 312 documents
A Quality Risk Management Model Approach for Cell Therapy Manufacturing
2010
International regulatory authorities view risk management as an essential production need for the development of innovative, somatic cell-based therapies in regenerative medicine. The available risk management guidelines, however, provide little guidance on specific risk analysis approaches and procedures applicable in clinical cell therapy manufacturing. This raises a number of problems. Cell manufacturing is a poorly automated process, prone to operator-introduced variations, and affected by heterogeneity of the processed organs/tissues and lot-dependent variability of reagent (e.g., collagenase) efficiency. In this study, the principal challenges faced in a cell-based product manufacturi…
Assessing supply chain risks in the automotive industry through a modified MCDM-based FMECA
2020
Supply chains are complex networks that receive assiduous attention in the literature. Like any complex network, a supply chain is subject to a wide variety of risks that can result in significant economic losses and negative impacts in terms of image and prestige for companies. In circumstances of aggressive competition among companies, effective management of supply chain risks (SCRs) is crucial, and is currently a very active field of research. Failure Mode, Effects and Criticality Analysis (FMECA) has been recently extended to SCR identification and prioritization, aiming at reducing potential losses caused by lack of risk control. This article has a twofold objective. First, SCR assess…
Root cause analysis of large scale application testing results
2015
In this paper we present a new root cause analysis algorithm for discovering the most likely causes of the differences found in testing results of two versions of the same software. The problematic points in test and environment attribute hierarchies are presented to the user in compact way which in turn allows to save time on test result processing. We have proven that for clearly separated problem causes our algorithm gives exact solution. Practical application of described method is discussed.
Heavy-Flavor Contribution to Bhabha Scattering
2008
We evaluate the last missing piece of the two-loop QED corrections to the high-energy electron-positron scattering cross section originating from the vacuum polarization by heavy fermions. The calculation is performed within a new approach applicable to a wide class of perturbative problems with mass hierarchy. The result is crucial for the high-precision physics program at existing and future e(+) e(-) colliders.
Problematic aspects of models of culture in European legal culture and selected personal models of people of the road
2016
the aim of the hereby paper is not to present a standpoint related to the term and structure of culture, it is to present the models of culture from a perspective of scientists that undertake this matter. Therefore, the problematic issues of models of culture have been presented, with regard to differentiation of standpoints presented by authors undertaking the matter. Against this background, the problem of placing personal models of culture within changes that take place in culture, seems to outline distinctively. the issue of personal models is related to the sphere of cultural values. These determine the changes that take place in the area of culture: the deeper the alterations in cultu…
Management of uncertain pairwise comparisons in AHP through probabilistic concepts
2019
Abstract Fast and judicious decision-making is paramount for the success of many activities and processes. However, various degrees of difficulty may affect the achievement of effective and optimal solutions. Decisions should ideally meet the best trade-off among as many of the involved factors as possible, especially in the case of complex problems. Substantial cognitive and technical skills are indispensable, while not always sufficient, to carry out optimal evaluations. One of the most common causes of wrong decisions derives from uncertainty and vagueness in making forecasts or attributing judgments. The literature shows numerous efforts towards the optimization and modeling of uncertai…
Assessing the sustainability of small wastewater treatment systems: A composite indicator approach
2014
The assessment of the sustainability of wastewater treatment (WWT) systems has gained interest in recent years. However, most previous studies have focused on environmental and/or economic dimensions ignoring social aspects. Moreover, they tend to be based on sets of indicators rather than providing a holistic assessment. To overcome this limitation, this paper proposes an innovative methodology to assess the sustainability of WWT systems based on the development of a composite indicator embracing economic, environmental and social issues. Subsequently, the global sustainability of seven WWT technologies for secondary treatment in small communities is compared. The joint application of the …
Handling stakeholder uncertain judgments in strategic transport service analyses
2013
Abstract The quality level of services has to be constantly controlled, especially under conditions of competition increasing and limited resources. However, considering that service performance analyses are based on stakeholders' judgments, they can be characterized by possible uncertainties related to incompleteness for partial ignorance, imprecision for subjectivity and even vagueness. Therefore, under these conditions, unreliable results can be obtained by widely used service analysis methodologies. In the present paper, a methodology based on a recent extension of the SERVQUAL model, and that uses in combined manner the fuzzy set theory and the analytic hierarchy process method is prop…
Interaction between functional and relational service quality: hierarchy vs. compensation
2018
The main goal of this research study is to examine the form of interaction between functional and relational service quality in their links to customer satisfaction. Two competing hypotheses were t...
A Hierarchy of Twofold Resource Allocation Automata Supporting Optimal Sampling
2009
We consider the problem of allocating limited sampling resources in a "real-time" manner with the purpose of estimating multiple binomial proportions. More specifically, the user is presented with `n ' sets of data points, S 1 , S 2 , ..., S n , where the set S i has N i points drawn from two classes {*** 1 , *** 2 }. A random sample in set S i belongs to *** 1 with probability u i and to *** 2 with probability 1 *** u i , with {u i }. i = 1, 2, ...n , being the quantities to be learnt. The problem is both interesting and non-trivial because while both n and each N i are large, the number of samples that can be drawn is bounded by a constant, c . We solve the problem by first modelling it a…