Search results for "hla"
showing 10 items of 664 documents
Modification of the proteolytic fragmentation pattern upon oxidation of cysteines from ribulose 1,5-bisphosphate carboxylase/oxygenase.
2003
The proteolytic susceptibility of the native CO 2 -fixing photosynthetic enzyme ribulose 1,5-bisphosphate carboxylase/oxygenase (EC 4.1.1.39, Rubisco) has been shown to increase in vitro after oxidative treatments that affect cysteine thiols. A limited incubation of oxidized (pretreated with the disulfide cystamine) Rubisco from Chlamydomonas reinhardtii with subtilisin or proteinase K generated fragments of molecular mass about 53 kDa (band I in SDS-PAGE) and 47 kDa (band II) derived from the large subunit (55 kDa) of the enzyme. In contrast, proteolysis of the reduced Rubisco (pretreated with the free thiol cysteamine) produced only the 53 kDa band. The same fragmentation pattern was repr…
Sicilia aghlabita: nuove testimonianze numismatiche
2012
Questo saggio si propone di illustrare 22 sigilli di piombo di età aghlabita di provenienza siciliana1. Gli esemplari presi in esame, sebbene inediti, afferiscono ad una tipologia già delineata in due studi precedenti dei quali il primo, a firma di P. Balog, risale al 1979 e il secondo, pubblicato da chi scrive, risale al 2003. I sigilli pubblicati dall'autrice, a differenza di quelli illustrati dal Balog e dei nuovi che qui mi accingo ad illustrare, costituiscono il frutto di una campagna di scavo ufficiale condotta nell’area archeologica di Milena (Sicilia: provincia di Caltanissetta) e hanno dunque, rispetto a tutti gli altri, il pregio di provenire da un sito studiato a fondo dagli arch…
A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies
2023
The NRF2 pathway is frequently activated in various cancer types, yet a comprehensive analysis of its effects across different malignancies is currently lacking. We developed a NRF2 activity metric and utilized it to conduct a pan-cancer analysis of oncogenic NRF2 signaling. We identified an immunoevasive phenotype where high NRF2 activity is associated with low interferon-gamma (IFNγ), HLA-I expression and T cell and macrophage infiltration in squamous malignancies of the lung, head and neck area, cervix and esophagus. Squamous NRF2 overactive tumors comprise a molecular phenotype with SOX2/TP63 amplification, TP53 mutation and CDKN2A loss. These immune cold NRF2 hyperactive diseases are a…
Flavour Les Houches Accord: Interfacing Flavour related Codes
2010
14 páginas, 2 tablas.-- arXiv:1008.0762v2.-- Mahmpudi, F. et al.
Global effective-field-theory analysis of new-physics effects in (semi)leptonic kaon decays
2016
We analyze the decays $K\to\pi\ell\nu$ and $P\to\ell\nu$ ($P=K,\pi$, $\ell=e,\,\mu$) using a low-energy Effective-Field-Theory approach to parametrize New Physics and study the complementarity with baryon $\beta$ decays. We then provide a road map for a global analysis of the experimental data, with all the Wilson coefficients simultaneously, and perform a fit leading to numerical bounds for them and for $V_{us}$. A prominent result of our analysis is a reinterpretation of the well-known $V_{ud}-V_{us}$ diagram as a strong constraint on new physics. Finally, we reinterpret our bounds in terms of the $SU(2)_L\times~U(1)_Y$-invariant operators, provide bounds to the corresponding Wilson coeff…
Non-standard semileptonic hyperon decays
2014
We investigate the discovery potential of semileptonic hyperon decays in terms of searches of new physics at teraelectronvolt scales. These decays are controlled by a small $SU(3)$-flavor breaking parameter that allows for systematic expansions and accurate predictions in terms of a reduced dependence on hadronic form factors. We find that muonic modes are very sensitive to non-standard scalar and tensor contributions and demonstrate that these could provide a powerful synergy with direct searches of new physics at the LHC.
Hadronic light-by-light contribution to $(g-2)_\mu $ from lattice QCD: a complete calculation
2021
The European physical journal / C 81(7), 651 (2021). doi:10.1140/epjc/s10052-021-09455-4
Density distributions in the $B$ meson
2016
We report on a two-flavor lattice QCD study of the axial, charge and matter distributions of the $B$ meson and its first radial excitation. As our framework is the static limit of Heavy Quark Effective Theory (HQET), taking their Fourier transform gives access to several form factors at the kinematical point $q^2=0$. Moreover they provide some useful information on the nature of an excited state, i.e. a radial excitation of a quark-antiquark bound state or a multihadron state.
Isolation and Characterization of CD276+/HLA-E+ Human Subendocardial Mesenchymal Stem Cells from Chronic Heart Failure Patients: Analysis of Differen…
2012
Mesenchymal stem cells (MSCs) are virtually present in all postnatal organs as well as in perinatal tissues. MSCs can be differentiated toward several mature cytotypes and interestingly hold potentially relevant immunomodulatory features. Myocardial infarction results in severe tissue damage, cardiomyocyte loss, and eventually heart failure. Cellular cardiomyoplasty represents a promising approach for myocardial repair. Clinical trials using MSCs are underway for a number of heart diseases, even if their outcomes are hampered by low long-term improvements and the possible presence of complications related to cellular therapy administration. Therefore, elucidating the presence and role of MS…
Second European Multi-Disciplinary Conference of National Strategies for Chlamydia Trachomatis and Human Papillomavirus (NSCP Conference) in Berlin, …
2013
There is a need for updated guidance on detection, management and surveillance of sexually transmitted infections (STIs). Chlamydia, gonorrhoea and syphilis reporting needs to be mandatory in more European countries to aid collection of data. More widespread Chlamydia screening is needed in many countries as this is the only way to reduce complications. The role of Human Papillomavirus (HPV) screening in a situation where the prevalence of HPV infection has dropped significantly was also discussed in the context of the high cost of screening, the need for a relatively complex infrastructure, particularly in developing countries, and falling vaccination costs. An integrated HPV vaccination …