Search results for "hoito"

Competition between marine mammals and fisheries in contemporary harvested marine ecosystems

2019

Competitive interactions between marine mammals and fisheries represent some of the most complex challenges in marine resource management worldwide. The development of commercial fisheries and recovering marine mammal populations have contributed to a decrease in fish availability. Whilst ecosystem-based fisheries management (EBFM) can counteract this decrease, achieving the EBFM objectives faces certain major obstacles including insufficient or unreliable data, inapplicable assessment models, as well as inadequate management decisions that do not account for fisheries-induced morphological alterations (FIMA) and marine mammal management. Despite a body of evidence addressing various aspect…

What are the effects of even-aged and uneven-aged forest management on boreal forest biodiversity in Fennoscandia and European Russia? A systematic r…

2021

Abstract Background Forest harvesting changes forest habitat and impacts forest dependent species. Uneven-aged management is often considered better for biodiversity than even-aged management, but there is an ongoing discourse over the benefits and disadvantages of different silvicultural systems. This systematic review contributes to the public discussion and provides evidence for policy making by synthesising current evidence on impacts of even-aged and uneven-aged forest management on biodiversity in boreal forests of Fennoscandia and European Russia. In this review even-aged and uneven-aged forest management are compared directly to each other as well as to natural forest to provide a b…

Care Workers’ Readiness for Robotization : Identifying Psychological and Socio-Demographic Determinants

2020

Successful implementation of robots in welfare services requires that the staff approves of them as a part of daily work tasks. In this study, we identified psychological and socio-demographic determinants associated with readiness for robotization among professional Finnish care-workers. National survey data were collected from professional care workers (n = 3800) between October and November 2016. Random samples were drawn from the member registers of two Finnish trade unions. The data were analyzed with regression models for respondents with and without firsthand experience with robots. The models explained 34–39% of the variance in the readiness for robotization. The readiness was posit…

Antitumor effect of oncolytic virus and paclitaxel encapsulated in extracellular vesicles for lung cancer treatment

2018

Standard of care for cancer is commonly a combination of surgery with radiotherapy or chemoradiotherapy. However, in some advanced cancer patients this approach might still remaininefficient and may cause many side effects, including severe complications and even death. Oncolytic viruses exhibit different anti-cancer mechanisms compared with conventional therapies, allowing the possibility for improved effect in cancer therapy. Chemotherapeutics combined with oncolytic viruses exhibit stronger cytotoxic responses and oncolysis. Here, we have investigated the systemic delivery of the oncolytic adenovirus and paclitaxel encapsulated in extracellular vesicles (EV) formulation that, in vitro, s…

Acute Exercise Modulates Pain-induced Response on Sensorimotor Cortex ∼20 Hz Oscillation.

2019

Exercise affects positively on self-reported pain in musculoskeletal pain conditions possibly via top-down pain inhibitory networks. However, the role of cortical activity in these networks is unclear. The aim of the current exploratory study was to investigate the effects of acute exercise on cortical nociceptive processing and specifically the excitability in the human sensorimotor cortex. Five healthy adults (mean age 32.8 years) were recorded with a whole-head 306-channel magnetoencephalography (MEG, Elekta Neuromag® Triux™). Participant’s right hand third fingertip was stimulated electrically with an intracutaneous non-magnetic copper tip electrode before and immediately after an exerc…

Estrogenic regulation of skeletal muscle proteome : a study of premenopausal women and postmenopausal MZ cotwins discordant for hormonal therapy

2017

Female middle age is characterized by a decline in skeletal muscle mass and performance, predisposing women to sarcopenia, functional limitations, and metabolic dysfunction as they age. Menopausal loss of ovarian function leading to low circulating level of 17b-estradiol has been suggested as a contributing factor to aging-related muscle deterioration. However, the underlying molecular mechanisms remain largely unknown and thus far androgens have been considered as a major anabolic hormone for skeletal muscle. We utilized muscle samples from 24 pre- and postmenopausal women to establish proteome-wide profiles, associated with the difference in age (30–34 years old vs. 54– 62 years old), men…

Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement

2018

Tissue-specific effects of 17 beta-estradiol are delivered via both estrogen receptors and microRNAs (miRs). Menopause is known to affect the whole-body fat distribution in women. This investigation aimed at identifying menopause-and hormone replacement therapy (HRT)-associated miR profiles and miR targets in subcutaneous abdominal adipose tissue and serum from the same women. A discovery phase using array technology was performed in 13 women, including monozygotic twin pairs discordant for HRT and premenopausal young controls. Seven miRs, expressed in both adipose tissue and serum, were selected for validation phase in 34 women from a different cohort. An age/menopause-related increase of …

Modulation of impulsive behaviours using transcranial random noise stimulation

2021

Cold-water immersion combined with active recovery is equally as effective as active recovery during 10 weeks of high-intensity combined strength and…

2019

Summary Study aim: The purpose of this study was to compare the effects of cold-water immersion (CWI) vs. active recovery performed after each individual strength and endurance training session over a 10-week period of high-intensity combined strength and endurance training. Materials and methods: Seventeen healthy men completed 10 weeks of high-intensity combined strength and endurance training. One group (AR, n = 10) completed active recovery that included 15 minutes of running at 30–40% VO2max after every strength training session while the other group (CWI, n = 7) completed 5 minutes of active recovery (at the same intensity as the AR group) followed by 10 minutes of cold-water (12 ± 1°…

ACT for sleep - Internet-delivered self-help ACT for sub-clinical and clinical insomnia : A randomized controlled trial

2019

Background: Sleep disturbances are a common health problem. New and more accessible alternatives are needed to improve the availability of psychological treatments for insomnia. - Objective: The aim of the present study was to investigate the effects of a self-help Acceptance and Commitment Therapy-based web-intervention for sleep disturbances. - Method: Participants (N = 86) reporting symptoms of insomnia were randomly assigned to an Internet-delivered ACT (iACT, n = 43) or a control condition (WLC, n = 40) and assessed with standardized self-report measures related to sleep (ISI, BNSQ, ESS, DBAS), psychological symptoms (BDI-II, SCL-90), life satisfaction, and ACT-related processes (AAQ-2…