Search results for "holding"
showing 10 items of 123 documents
Time course of adverse events most commonly associated with topiramate for migraine prevention
2007
The efficacy, safety and tolerability of topiramate has been demonstrated in three large multicenter, randomized, double-blind, placebo-controlled trials. To characterize the time course of adverse events (AEs) that led to treatment discontinuation in/=2% of patients who received topiramate 100 mg/day during three pivotal, multicenter, randomized, double-blind, placebo-controlled, and 26-week trials. The pooled population comprised all randomized patients who reported safety data during the double-blind phase (topiramate 100 mg/day, n = 386; placebo n = 372), which consisted of a 4-week titration period and a 22-week maintenance period. Incidence, time to onset, and cumulative mean rate of …
Clinical activity after fingolimod cessation: Disease reactivation or rebound?
2018
Background and purpose There is debate as to whether the apparent rebound after fingolimod discontinuation is related to the discontinuation itself or whether it is due to the natural course of highly active multiple sclerosis (MS). Our aim was to survey the prevalence of severe reactivation and rebound after discontinuation of fingolimod in a cohort of Italian patients with MS. Methods Patients with relapsing-remitting MS who were treated with fingolimod for at least 6 months and who stopped treatment for reasons that were unrelated to inefficacy were included in the analysis. Results A total of 100 patients who had discontinued fingolimod were included in the study. Fourteen patients (14%…
Electroencephalographic alpha activity modulations induced by breath-holding in apnoea divers and non-divers.
2017
Little is known regarding cortical responses to sustained breath-holding (BH) in expert apnoea divers. The present study therefore investigated electroencephalographic (EEG) alpha activity and asymmetries in apnoea divers (experts) compared to non-divers (novices). EEG of 10 apnoea and 10 non-divers were recorded in the laboratory for either four minutes or for two minutes of BH. Alpha activity and alpha asymmetry (i.e. hemispherical EEG differences) were calculated and compared between expertise level and BH duration. Alpha amplitude in experts significantly decreased at four minutes of BH compared to resting activity, while alpha amplitude significantly decreased in novices only at centro…
Early discontinuation of ribavirin in HCV-2 and HCV-3 patients responding to Peg-interferon alpha-2a and ribavirin
2008
Guidelines for the treatment of patients infected with hepatitis C virus of genotypes 2 and 3 (HCV-2 and HCV-3, respectively) recommend a 24-week course of Peg-interferon (Peg-IFN) alpha-2a combined with ribavirin, despite 50% of patients in registration trials attaining a sustained virologic response (SVR) following Peg-IFN alpha-2a monotherapy. The aim of this study was to delineate patient characteristics that might help to identify individuals likely to benefit from ribavirin discontinuation. One hundred and forty-four HCV-2- and HCV-3-infected patients initiated Peg-IFN alpha-2a (180 microg/week) and ribavirin (1000 or 1200 mg/day); those with viral clearance at week 4 were randomized …
Persistence on Anti-Tumour Necrosis Factor Therapy in Older Patients with Inflammatory Bowel Disease Compared with Younger Patients: Data from the Si…
2020
BACKGROUND AND OBJECTIVE: Older people with inflammatory bowel disease (IBD) appear to have a lower response to anti-tumour necrosis factor (TNF) therapy, with more frequent complications than younger patients. The objective of this study was to assess persistence on therapy and the safety of anti-TNF therapy in older patients (aged ≥ 60 years). METHODS: We retrospectively reviewed the database of the Sicilian Network for Inflammatory Bowel Diseases (SN-IBD), extracting data regarding IBD patients aged ≥ 60 years and controls < 60 years of age at their first course of anti-TNF treatment. Data concerning persistence on therapy over the first year of treatment (primary objective) together …
Trainability of underwater breath-holding time.
1984
From diving practice we know that breath-holding time (BHT) can be increased by training. This examination was set up to illuminate whether BHT underwater can be trained decisively in a short period of time. The authors investigated whether physiologic or psychological aspects are the main constituents of the above-mentioned BHT phenomenon. BHT and the "onset point" of involuntary respiratory movements of 64 subjects were registered after deep inspiration and immersion in ca. 1 m. Two different tests were set up: (I) 2 breath-holds per day on 5 consecutive days, (II) 5 repeated breath-holds with pauses of 3 min in between. BHT of the first test was shorter underwater than in similar experim…
Application of pulsed electric fields in meat and fish processing industries: An overview.
2019
The market demand for new meat and fish products with enhanced physicochemical and nutritional properties attracted the interest of the food industry and academia to investigate innovative processing approaches such as pulsed electric fields (PEF). PEF is an emerging technology based on the application of electrical currents between two electrodes thus inducing electroporation phenomena and enabling a non-invasive modification of the tissues' structure. This review provides an overview of the current knowledge on the use of PEF processing in meat and fish to enhance the physicochemical and nutritional changes, as a preservation method, as well as for improving the extraction of high added-v…
The Vuelo Ruiz de Alda (1929-30): an exceptional cartographic document. Again about Ilici
2015
Se presenta en este artículo una primera valoración de las posibilidades que para la arqueología, y más concretamente para la estratigrafía del paisaje, encierra un soberbio documento como es la serie fotográfica conocida como Vuelo Ruiz de Alda (1929-30), una vez que los fotogramas han sido ampliamente puestos al alcance de la investigación. Para ello se ponen a prueba las imágenes aplicándolas a dos establecimientos de época ibérica antigua (El Oral y El Molar). Igualmente, se ha retomado una línea de investigación a propósito de la red caminera que afecta al enclave de La Alcudia-Ilici, lo que lleva implícitamente a tratar sobre su catastro romano y la trama parcelaria de todo su entorno…
A Segmentation System for Soccer Robot Based on Neural Networks
2000
An innovative technique for segmentation of color images is proposed. The technique implements an approach based on thresholding of the hue histogram and a feed-forward neural network that learns to recognize the hue ranges of meaningful objects. A new function for detecting valleys of the histogram has been devised and tested. A novel blurring algorithm for noise reduction that works effectively when used over hue image has been employed. The reported experimental results show that the technique is reliable and robust even in presence of changing environmental conditions. Extended experimentation has been carried on the framework of the Robot Soccer World Cup Initiative (RoboCup).
Adaptive Continuous Feature Binarization for Tsetlin Machines Applied to Forecasting Dengue Incidences in the Philippines
2020
The Tsetlin Machine (TM) is a recent interpretable machine learning algorithm that requires relatively modest computational power, yet attains competitive accuracy in several benchmarks. TMs are inherently binary; however, many machine learning problems are continuous. While binarization of continuous data through brute-force thresholding has yielded promising accuracy, such an approach is computationally expensive and hinders extrapolation. In this paper, we address these limitations by standardizing features to support scale shifts in the transition from training data to real-world operation, typical for e.g. forecasting. For scalability, we employ sampling to reduce the number of binariz…