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GLP-2 as Beneficial Factor in the Glucose Homeostasis in Mice Fed a High Fat Diet

2015

Glucagon like peptide-2 (GLP-2) is a gastrointestinal hormone released in response to dietary nutrients, which acts through a specific receptor, the GLP-2 receptor (GLP-2R). The physiological effects of GLP-2 are multiple, involving also the intestinal adaptation to high fat diet (HFD). In consideration of the well-known relationship between chronic HFD and impaired glucose metabolism, in the present study we examined if the blocking of the GLP-2 signaling by chronic treatment with the GLP-2R antagonist, GLP-2 (3-33), leads to functional consequences in the regulation of glucose metabolism in HFD-fed mice. Compared with animals fed standard diet (STD), mice at the 10th week of HFD showed hy…

Acute selective ablation of rat insulin promoter-expressing (RIP HER ) neurons defines their orexigenic nature

2012

Rat insulin promoter (RIP)-expressing neurons in the hypothalamus control body weight and energy homeostasis. However, genetic approaches to study the role of these neurons have been limited by the fact that RIP expression is predominantly found in pancreatic β-cells, which impedes selective targeting of neurons. To define the function of hypothalamic RIP-expressing neurons, we set out to acutely and selectively eliminate them via diphtheria toxin-mediated ablation. Therefore, the diphtheria toxin receptor transgene was specifically expressed upon RIP-specific Cre recombination using a RIP-Cre line first described by Herrera (RIP HER -Cre) [Herrera PL (2000) Development 127:2317–2322]. Usi…

Role of glutathione in Thiobencarb resistance in the European eel Anguilla anguilla.

2000

Glutathione-dependent defense against xenobiotic toxicity is a multifaceted phenomenon that has been well characterized in mammals. In the present study, eels of species Anguilla anguilla were exposed to 15 ppm of the herbicide thiobencarb (S-4-chlorobenzyl diethylthiocarbamate) for 96 h. Eels exposed to the pesticide were grouped in 24-h intervals according to their time of death, while surviving intoxicated eels constituted another group (live animals). Glutathione content (GSx, GSH, GSSG) was determined in liver and muscle tissues of the dead and live (intoxicated) animals and compared to control values (nonexposed eels). The fish that died before 96 h of exposure were considered suscept…

2015

The melanocortin system is one of the most important neuronal pathways involved in the regulation of food intake and is probably the best characterized. Agouti-related peptide (AgRP) and proopiomelanocortin (POMC) expressing neurons located in the arcuate nucleus of the hypothalamus are the key elements of this system. These two neuronal populations are sensitive to circulating molecules and receive many excitatory and inhibitory inputs from various brain areas. According to sensory and metabolic information they integrate, these neurons control different aspects of feeding behavior and orchestrate autonomic responses aimed at maintaining energy homeostasis. Interestingly, composition and a…

Elevated cortisol modulates hsp70 and hsp90 gene expression and protein in sea bass head kidney and isolated leukocytes

2012

In fish, interactions between Hsps and cortisol are involved in stress modulated physiological processes including innate immune responses. Cortisol exerts a role in the regulation of Hsps synthesis. Fish head kidney is a lymphomieloid and endocrine organ releasing cortisol, and it is the central organ for immune-endocrine interactions. In sea bass, cortisol intraperitoneal injection and in vitro treatment of head kidney cells show that inducible Hsp70 and Hsp90 are modulated by this hormone. However, an inverse relationship between mRNA expression (real-time PCR) and Hsp70 and Hsp90 protein levels (densitometric band analysis) was found. Time-course assays indicate a cortisol-mediated regu…

Dom utracony, dom odzyskany... (?) : powrót do "małej ojczyzny" w wierszu Czesława Miłosza "Dwór"

2016

Czesław Miłosz’s poem Dwór [trans. Manor] may be understood as the author’s poetical recollection of visiting his homeland. This return results in a specific temporal and spatial perspective. A noiseless walk through a place which once was both close and well-known is an impulse for comparisons between the present and the past, and for personal thoughts of existential character. The artistic descriptions of the changes at the Nevezis river and the physical absence of the manor, positions time as the enemy of men and nature. This image finds its conclusion in the comparison of the man to the manor. As a consequence, the poem becomes a commentary of the inevitable passage of time and the need…

An Energy-Autonomous Wireless Sensor with Simultaneous Energy Harvesting and Ambient Light Sensing

2021

Wireless sensor nodes (WSNs) are generally powered by batteries, which results in a substantial limitation to the places where the nodes can be installed, to the maximum number of deployable devices, and to the node lifetime. To meet the demand for Internet-of-Things (IoT) applications that require a large number of maintenance-free, low cost, wireless sensor nodes, this paper proposes a wireless sensor platform with a single photovoltaic transducer that performs the dual role of harvesting energy and sensing ambient light. This dual use allows even smaller and cheaper nodes that do not require any form of supporting external power, with a reduced component count. The device implements off-…

In vivo evaluation of the effects of 10% carbamide peroxide and 3.5% hydrogen peroxide on the enamel surface

2007

Objectives: Bleaching of vital teeth performed at home by the patient under the dentist’s supervision, using low-concentration peroxides and custom-fitted trays specifically designed for this purpose, is one of several options for this type of dental treatment, whether alone or in combination with another in-office bleaching technique. The objective of this study is to analyse the effect on the enamel surface of two bleaching products recommended for this technique. Materials & methods: Two bleaching products were used: VivaStyle (Vivadent), a 10% carbamide peroxide, and FKD (Kin), a 3.5% hydrogen peroxide. They were applied in trays to the anterior teeth of 20 patients (10 in each group). …

Kuinka tavoittaa hoivakodin henki? : valokuvaelisitaatio tutkimusmetodina

2014

Laitoksissa ja palvelukodeissa asuvien vanhusten tutkimista kyselyjen ja haastattelujen avulla pidetään pulmallisena, koska asukkaat ovat informantteina tietyssä mielessä marginaalinen ihmisryhmä. Tässä yhteydessä marginaalinen tarkoittaa, että he ovat usein hyvin hauraita toimintakyvyltään. Heidän on esimerkiksi aistitoimintojen rajoitteiden ja sairauksien vuoksi hankala osallistua tutkimuksiin. Heidän äänensä ei ole tullut riittävästi kuulluksi palvelujen käyttäjinä ja tutkimustulokset ovat siten jääneet siltä osin melko laihoiksi. (Koskela 2010; Outinen 1999.) Ratkaisuna on ehdotettu teknisten ja monimutkaisten laatumittausten rinnalle aistivaraisen laadun käsitettä ja siihen niveltyviä …

Glial Chloride Homeostasis Under Transient Ischemic Stress

2021

High water permeabilities permit rapid adjustments of glial volume upon changes in external and internal osmolarity, and pathologically altered intracellular chloride concentrations ([Cl–]int) and glial cell swelling are often assumed to represent early events in ischemia, infections, or traumatic brain injury. Experimental data for glial [Cl–]int are lacking for most brain regions, under normal as well as under pathological conditions. We measured [Cl–]int in hippocampal and neocortical astrocytes and in hippocampal radial glia-like (RGL) cells in acute murine brain slices using fluorescence lifetime imaging microscopy with the chloride-sensitive dye MQAE at room temperature. We observed s…