Search results for "homology"

Negative Regulation of β Enolase Gene Transcription in Embryonic Muscle Is Dependent upon a Zinc Finger Factor That Binds to the G-rich Box within th…

1998

We have previously identified a muscle-specific enhancer within the first intron of the human beta enolase gene. Present in this enhancer are an A/T-rich box that binds MEF-2 protein(s) and a G-rich box (AGTGGGGGAGGGGGCTGCG) that interacts with ubiquitously expressed factors. Both elements are required for tissue-specific expression of the gene in skeletal muscle cells. Here, we report the identification and characterization of a Kruppel-like zinc finger protein, termed beta enolase repressor factor 1, that binds in a sequence-specific manner to the G-rich box and functions as a repressor of the beta enolase gene transcription in transient transfection assays. Using fusion polypeptides of b…

Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling

2014

The generation of excessive amounts of reactive oxygen species (ROS) leads to cellular oxidative stress that underlies a variety of forms of hepatocyte injury and death including that from alcohol. Although ROS can induce cell damage through direct effects on cellular macromolecules, the injurious effects of ROS are mediated largely through changes in signal transduction pathways such as the mitogen-activated protein kinase c-Jun N-terminal kinase (JNK). In response to alcohol, hepatocytes have increased levels of the enzyme cytochrome P450 2E1 (CYP2E1) which generates an oxidant stress that promotes the development of alcoholic steatosis and liver injury. These effects are mediated in larg…

An improvement of a bound of Green

2012

A p-group G of order pn (p prime, n ≥ 1) satisfies a classic Green's bound log p |M(G)| ≤ ½n(n - 1) on the order of the Schur multiplier M(G) of G. Ellis and Wiegold sharpened this restriction, proving that log p |M(G)| ≤ ½(d - 1)(n + m), where |G′| = pm(m ≥ 1) and d is the minimal number of generators of G. The first author has recently shown that log p |M(G)| ≤ ½(n + m - 2)(n - m - 1) + 1, improving not only Green's bound, but several other inequalities on |M(G)| in literature. Our main results deal with estimations with respect to the bound of Ellis and Wiegold.

Rank two aCM bundles on the del Pezzo fourfold of degree 6 and its general hyperplane section

2018

International audience; In the present paper we completely classify locally free sheaves of rank 2 with vanishing intermediate cohomology modules on the image of the Segre embedding $\mathbb{P}^2$ x $\mathbb{P}^2 \subseteq \mathbb{P}^8$ and its general hyperplane sections.Such a classification extends similar already known results regarding del Pezzo varieties with Picard numbers 1 and 3 and dimension at least 3.

Obstruction theory in action accessible categories

2013

Abstract We show that, in semi-abelian action accessible categories (such as the categories of groups, Lie algebras, rings, associative algebras and Poisson algebras), the obstruction to the existence of extensions is classified by the second cohomology group in the sense of Bourn. Moreover, we describe explicitly the obstruction to the existence of extensions in the case of Leibniz algebras, comparing Bourn cohomology with Loday–Pirashvili cohomology of Leibniz algebras.

The Abel–Jacobi map for higher Chow groups

2006

We construct a map between Bloch's higher Chow groups and Deligne homology for smooth, complex quasiprojective varieties on the level of complexes. For complex projective varieties this results in a formula which generalizes at the same time the classical Griffiths Abel–Jacobi map and the Borel/Beilinson/Goncharov regulator type maps.

Pseudodifferential Analysis on Manifolds with Boundary — a Comparison of b-Calculus and Cone Algebra

2001

We establish a relation between two different approaches to a complete pseudodifferential analysis of totally characteristic or Fuchs type operators on compact manifolds with boundary respectively conical singularities: Melrose’s (overblown) b-calculus and Schulze’s cone algebra. Though quite different in their definition, we show that these two pseudodifferential calculi basically contain the same operators.

Hodge Numbers for the Cohomology of Calabi-Yau Type Local Systems

2014

We determine the Hodge numbers of the cohomology group \(H_{L^{2}}^{1}(S, \mathbb{V}) = H^{1}(\bar{S},j_{{\ast}}\mathbb{V})\) using Higgs cohomology, where the local system \(\mathbb{V}\) is induced by a family of Calabi-Yau threefolds over a smooth, quasi-projective curve S. This generalizes previous work to the case of quasi-unipotent, but not necessarily unipotent, local monodromies at infinity. We give applications to Rohde’s families of Calabi-Yau 3-folds.

Equivariant algebraic vector bundles over cones with smooth one dimensional quotient

1998

The module structure of Hochschild homology in some examples

2008

Abstract In this Note we give a simple proof of a conjecture by A. Caldararu stating the compatibility between the modified Hochschild–Kostant–Rosenberg isomorphism and the action of Hochschild cohomology on Hochschild homology in the case of Calabi–Yau manifolds and smooth projective curves. To cite this article: E. Macri` et al., C. R. Acad. Sci. Paris, Ser. I 346 (2008).