Search results for "hsc"
showing 10 items of 123 documents
Efficacy and safety of bempedoic acid for the treatment of hypercholesterolemia: A systematic review and meta-analysis
2020
Background Bempedoic acid is a first-in-class lipid-lowering drug recommended by guidelines for the treatment of hypercholesterolemia. Our objective was to estimate its average effect on plasma lipids in humans and its safety profile. Methods and findings We carried out a systematic review and meta-analysis of phase II and III randomized controlled trials on bempedoic acid (PROSPERO: CRD42019129687). PubMed (Medline), Scopus, Google Scholar, and Web of Science databases were searched, with no language restriction, from inception to 5 August 2019. We included 10 RCTs (n = 3,788) comprising 26 arms (active arm [n = 2,460]; control arm [n = 1,328]). Effect sizes for changes in lipids and high-…
Toward sustainable environmental quality : Priority research questions for Europe
2018
P.J. Van den Brink et al.
Minimally implicit Runge-Kutta methods for Resistive Relativistic MHD
2016
The Relativistic Resistive Magnetohydrodynamic (RRMHD) equations are a hyperbolic system of partial differential equations used to describe the dynamics of relativistic magnetized fluids with a finite conductivity. Close to the ideal magnetohydrodynamic regime, the source term proportional to the conductivity becomes potentially stiff and cannot be handled with standard explicit time integration methods. We propose a new class of methods to deal with the stiffness fo the system, which we name Minimally Implicit Runge-Kutta methods. These methods avoid the development of numerical instabilities without increasing the computational costs in comparison with explicit methods, need no iterative …
Orationes tres
1594
Mollīna tipogrāfijā nodrukātas Orationes tres: trīs runas, ko turēja sholarhi (Rīgas rātes prokonsuls Nikolajs Eke; 1541-1623 un sindiks Dāvids Hilhens; 1561-1610) un Domskolas rektors Johans Rīvijs (Rivius, 1528-1596, Domskolas rektors (1589) un inspektors (1594)) reorganizētās Domskolas atjaunošanai veltītajā svinīgajā pasākumā 1589. gada 15. jūlijā. Vairāki grāmatas eksemplāri bija domāti dāvināšanai ievērojamām Rīgas personām, tāpēc iesieti grezni: brūnā ādā, ar Rīgas ģerboni zelta iespiedumā uz vāka. Runu tekstus papildina tabulas, kur fiksēts visu triju skolas klašu stundu plāni. Runu izdošana un iespiešana ilga četrus gadus. Izdevums kavējās dēļ burtstabiņu trūkuma grieķu teksta iesp…
EcFLO, a FLORICAULA-like gene from Eschscholzia californica is expressed during organogenesis at the vegetative shoot apex.
2003
FLORICAULA/ LEAFY-like genes were initially characterized as flower meristem identity genes. In a range of angiosperms, expression occurs also in vegetative shoot apices and developing leaves, and in some species with dissected leaves expression is perpetuated during organogenesis at the leaf marginal blastozone. The evolution of these expression patterns and associated functions is not well understood. We have isolated and characterized a FLORICAULA-like gene from California Poppy, Eschscholzia californica Cham. (Papaveraceae), a species belonging to the basal eudicot clade Ranunculales. EcFLO encodes a putative 416-amino-acid protein with highest similarity to homologous genes from Trocho…
Oligodendroglioma cells shed microvesicles which contain TRAIL as well as molecular chaperones and induce cell death in astrocytes.
2011
Microvesicles (MVs) shed from G26/24 oligodendroglioma cells were previously reported to cause a reproducible, dose-dependent, inhibitory effect on neurite outgrowth, and eventually neuronal apoptosis, when added to primary cultures of rat cortical neurons. These effects were reduced but not abolished by functional monoclonal antibodies against Fas-L. In order to investigate whether MVs contain other factors able to induce cell death, we tested them for TRAIL and found clear evidence of its presence in the vesicles. This finding suggests the possibility that Fas-L and TRAIL cooperate in inducing brain cell death. Aimed at understanding the route through which the vesicles deliver their mess…
Oncolytic parvovirus H1 induces release of heat-shock protein HSP72 in susceptible human tumor cells but may not affect primary immune cells.
2003
Certain autonomous parvoviruses preferentially replicate in and kill in vitro-transformed cells and may reduce the incidence of spontaneous and implanted tumors in animals. Hence, these viruses and their derivatives are currently under evaluation as antitumor vectors. However, the mechanisms underlying their tumor-suppressing properties are not yet understood. We asked whether the lytic parvovirus H1 may enhance the immunogenicity of infected tumor cells. Out of human melanoma and gastrointestinal tumor cells, we selected the cell line SK29-Mel-1 being very susceptible to H1-induced apoptotic killing. Here, no upregulation of HLA class I and costimulatory molecules could be observed followi…
Stress response in mesoangioblast stem cells
2006
Stem cells are presumed to survive various stresses, since they are recruited to areas of tissue damage and regeneration, where inflammatory cytokines and cytotoxic cells may result in severe cell injury. We explored the ability of mesoangioblasts to respond to different cell stresses such as heat, heavy metals and osmotic stress, by analyzing heat shock protein (HSP)70 synthesis as a stress indicator. We found that the A6 mesoangioblast stem cells constitutively synthesize HSP70 in a heat shock transcription factor (HSF)-independent way. However, A6 respond to heat shock and cadmium treatment by synthesizing HSP70 over the constitutive expression and this synthesis is HSF1 dependent. The e…
Homology of pseudodifferential operators on manifolds with fibered cusps
2003
The Hochschild homology of the algebra of pseudodifferential operators on a manifold with fibered cusps, introduced by Mazzeo and Melrose, is studied and computed using the approach of Brylinski and Getzler. One of the main technical tools is a new convergence criterion for tri-filtered half-plane spectral sequences. Using trace-like functionals that generate the 0 0 -dimensional Hochschild cohomology groups, the index of a fully elliptic fibered cusp operator is expressed as the sum of a local contribution of Atiyah-Singer type and a global term on the boundary. We announce a result relating this boundary term to the adiabatic limit of the eta invariant in a particular case.
Should I use touchscreen tablets rather than computers and mice in TDS trials?
2016
International audience; Internet technologies are increasingly used as tools in sensory analysis. Thus, it would be a natural step forward for sensory science to move beyond the laboratory, into people's homes. Therefore, working with consumer IT devices like touchscreen tablets in sensory science should be taken into consideration. Working with the intuitive concept of dominance, Temporal Dominance of Sensations (TDS) requires a non-analytical answer from the subject. Using a touchscreen tablet instead of a classic mouse could reduce the cognitive load and favor a more instinctive answer. Indeed, it was proven that touch interaction is natural and efficient, and that finger pointing is fas…