Search results for "hydrogels"
showing 10 items of 299 documents
Radiation engineering of functional biomaterials: from smart hydrogels to theragnostic nanodevices
2009
Remineralization potential of grape seed extract hydrogels on bleached enamel compared to fluoride gel : an in vitro study
2019
Background Remineralizing of bleached enamel is a common procedure that aims to compensate enamel mineral lose. This study aimed to evaluate the remineralization effectiveness of experimentally prepared grape seed extract hydrogels (GSE) compared to fluoride gel on bleached enamel. Material and methods Thirty extracted maxillary incisor were bleached using white smile bleaching agent. Bleached specimens were divided into three groups (10/group) according to the remineralizing agents tested: [GSE 6%, GSE 10%, or fluoride gel]. After bleaching and remineralization procedure, the specimens were stored in artificial saliva at 37°C. Micro-hardness and Energy-Dispersive X-ray and ultra-morphologi…
The use of hydrogels in bone-tissue engineering
2010
Many different types of scaffold materials have been used for tissue engineering applications, and hydrogels form one group of materials that have been used in a wide variety of applications. Hydrogels are hydrophilic polymer networks and they represent an important class of biomaterials in biotechnology and medicine because many hydrogels exhibit excellent biocompatibility with minimal inflammatory responses and tissue damage. Many studies have demonstrated the use of hydrogels in bone-tissue engineering applications. In this report, the summary was conducted on various kinds of polymers and different modification methods of hydrogels to enhance bone formation. The results revealed that hy…
Development of a morphogenetically active scaffold for three-dimensional growth of bone cells: biosilica-alginate hydrogel for SaOS-2 cell cultivation
2013
Polymeric silica is formed from ortho-silicate during a sol–gel formation process, while biosilica is the product of an enzymatically driven bio-polycondensation reaction. Both polymers have recently been described as a template that induces an increased expression of the genes encoding bone morphogenetic protein 2 (BMP-2) and osteoprotegerin in osteoblast-related SaOS-2 cells; simultaneously or subsequently the cells respond with enhanced hydroxyapatite formation. In order to assess whether the biocompatible polymeric silica/biosilica can serve as a morphogenetically active matrix suitable for three-dimensional (3D) cell growth, or even for 3D cell bioprinting, SaOS-2 cells were embedded i…
Phosphorylation triggered growth of metal phosphate on halloysite and sepiolite nanoparticles: preparation, entrapment in chitosan hydrogels and appl…
2020
The rational design of porous, biomass-derived eco-friendly adsorbents instead of costly synthetic, petroleum-based resins stands as a promising approach to resolving the thorny issue of sewage treatment (for example, by supplying safe water for drinking and irrigation). Herein we explore a straightforward transformation of abundant clay and polysaccharides into highly-reactive water-cleaning adsorbents. Surface-functionalization of sepiolite and halloysite by phosphoryl chloride triggered metal dissolution from the framework (inside of the lumen for halloysite and on the external surface for sepiolite) and the concomitant growth of well-truncated crystalline metal phosphates. These unprece…
Bioactive glass ions induce efficient osteogenic differentiation of human adipose stem cells encapsulated in gellan gum and collagen type I hydrogels
2019
Abstract Background Due to unmet need for bone augmentation, our aim was to promote osteogenic differentiation of human adipose stem cells (hASCs) encapsulated in gellan gum (GG) or collagen type I (COL) hydrogels with bioactive glass (experimental glass 2-06 of composition [wt-%]: Na2O 12.1, K2O 14.0, CaO 19.8, P2O5 2.5, B2O3 1.6, SiO2 50.0) extract based osteogenic medium (BaG OM) for bone construct development. GG hydrogels were crosslinked with spermidine (GG-SPD) or BaG extract (GG-BaG). Methods Mechanical properties of cell-free GG-SPD, GG-BaG, and COL hydrogels were tested in osteogenic medium (OM) or BaG OM at 0, 14, and 21 d. Hydrogel embedded hASCs were cultured in OM or BaG OM fo…
Aggregation behavior of cationic nanohydrogel particles in human blood serum.
2014
For systemic siRNA delivery applications, well-defined drug carriers are required that guarantee stability for both carrier and cargo. Among various concepts progressing in market or final development, cationic nanohydrogel particles may serve as novel transport media especially designed for siRNA-in vivo experiments. In this work, the interaction of nanohydrogel particles with proteins and serum components was studied via dynamic light scattering in human blood serum as novel screening method prior to applications in vivo. The formation of larger aggregates mostly caused by charge interaction with albumin could be suppressed by nanogel loading with siRNA affording a neutral zeta potential …
Agarose/k-Carrageenan-based hydrogel films enriched with natural extracts for wound healing applications
2019
Hydrogels are 3D hydrophilic networks that can hold significant amounts of water within their structure, without dissolving in water. They can offer a combination of favorable properties, including high absorbency of biological fluids, biocompatibility, biodegradability, stimuli-responsiveness, high storage capacity and release ability of small and large therapeutic molecules. The hydrogel films designed for wound dressing may accomplish several functions, playing an important role in the healing processes. They can absorb and retain the wound exudates, stimulating fibroblast proliferation and keratinocyte migration and promoting re-epithelialization. Furthermore, they can incorporate and r…
Injectable hydrogel formulations to host adipose stem cell spheroids for stemness maintenance and bone and cartilage regeneration
2021
Adipose-derived mesenchymal stem cells (ASCs) represent a great promise for tissue regeneration as fat is a very abundant source of stem cells (1) and owing to their ability to self-renew and differentiate into specific tissue types (2). In general, they are usually cultured as two-dimensional (2D) adherent monolayers, not representative of the in vivo condition, often entailing lower cell viability and, more in general, a lower “cell quality” in terms of regenerative potential (3, 4). When ASCs are cultured in low adhesion flasks and with a suitable culture medium, they aggregate in the form of three-dimensional spheroids (SASCs). The incorporation of these spheroids into injectable, in-si…