Search results for "iCCA"
showing 10 items of 161 documents
Spray-Drying, Solvent-Casting and Freeze-Drying Techniques: a Comparative Study on their Suitability for the Enhancement of Drug Dissolution Rates.
2019
Purpose Solid dispersions (SDs) represent the most common formulation technique used to increase the dissolution rate of a drug. In this work, the three most common methods used to prepare SDs, namely spray-drying, solvent-casting and freezedrying, have been compared in order to investigate their effect on increasing drug dissolution rate. Methods Three formulation strategies were used to prepare a polymer mixture of polyvinyl-alcohol (PVA) and maltodextrin (MDX) as SDs loaded with the following three model drugs, all of which possess a poor solubility: Olanzapine, Dexamethasone, and Triamcinolone acetonide. The SDs obtained were analysed and compared in terms of drug particle size, drug-lo…
Solution of coupled riccati equations occurring in nash games
2006
To obtain the open-loop Nash strategy for a linear-quadratic differential game, a set of coupled matrix Riccati equations has to be solved. It is shown that by means of algebraic transformations, the original problem can be reduced to another one to which the successive approximation method is applicable. This leads to a simple iterative algorithm with a predetermined approximation error. An example is given to illustrate the proposed method.
Fungal-associated NO is involved in the regulation of oxidative stress during rehydration in lichen symbiosis
2010
[EN] Background Reactive oxygen species (ROS) are normally produced in respiratory and photosynthetic electron chains and their production is enhanced during desiccation/rehydration. Nitric oxide (NO) is a ubiquitous and multifaceted molecule involved in cell signaling and abiotic stress. Lichens are poikilohydrous organisms that can survive continuous cycles of desiccation and rehydration. Although the production of ROS and NO was recently demonstrated during lichen rehydration, the functions of these compounds are unknown. The aim of this study was to analyze the role of NO during rehydration of the lichen Ramalina farinacea (L.) Ach., its isolated photobiont partner Trebouxia sp. and Ast…
Mitochondria inheritance is a key factor for tolerance to dehydration in wine yeast production
2015
UNLABELLED Mitochondria are the cell's powerhouse when organisms are grown in the presence of oxygen. They are also the source of reactive oxygen species that cause damage to the biochemical components of the cell and lead to cellular ageing and death. Under winemaking conditions, Saccharomyces yeasts exclusively have a fermentative metabolism due to the high sugar content of grape must. However, their production as an active dry yeast (ADY) form required aerobic propagation and a dehydration process. In these industrial steps, oxidative stress is particularly harmful for the cell. In this work, we analysed the impact of the mitochondrial genome on oxidative stress response, longevity and d…
Investigation of the phase transitions occurring during and after the dehydration of xylazine hydrochloride monohydrate.
2014
This paper reports an investigation of a complex solid state phase transition where two inter-converting polymorphs (X and A) of the pharmaceutical molecule xylazine hydrochloride formed and transformed during and after the dehydration of its monohydrate (H). The crystal structures of all three forms were compared. During the investigation of this solid state phase transition it was determined that the dehydration of H produced either a pure X form, or a mixture of the X and A forms. The phase composition depended on the sample preparation procedure and the experimental conditions. It was found that grinding of the hydrate enhanced the formation of polymorph X as a product of dehydration, w…
Da Riccardo Quartararo a Cristoforo Faffeo. Un capolavoro del Museo Diocesano di Palermo restaurato e riscoperto
2016
Il volume, concepito secondo una metodologia multidisciplinare, propone all'attenzione degli studiosi nuovi dati per la conoscenza di una tavola dipinta dell'ultimo quarto del XV secolo proveniente al Museo Diocesano di Palermo dalla Cattedrale; finora attribuita a Riccardo Quartararo e identificata come Santa Cecilia solo per la presenza dell'angelo musico, l'opera viene qui correttamente riconosciuta, dopo il restauro, come Santa Barbara per l'imponente torre retrostante e attribuita al pittore napoletano Cristoforo Faffeo sulla base non solo di analogie stilistico-formali, ma di evidenze tecnico-esecutive e scientifiche nel confronto con altre opere riferite allo stesso e al Quartararo; …
Neurodidattica e apprendimento di lingue tipologicamente affini: italiano e spagnolo
2013
Il capitolo tratta in primis della Neurodidattica come trandisciplina, accenna ai concetti di Neurofisiologia e apprendimento, di Bimodalità, Intermodalità e Lateralizzazione,per poi passare alla disquisizione di concetti quali la Neurofisiologia dell’apprendimento linguistico. Tutta questa trattazione è propedeutica alla presentazione dello spagnolo come lingua seconda, della sua localizzazione nel cervello. Si esaminano, inoltre, i concetti di interlingua e interferenza in contesti italofoni. Infine si procede all'analisi della Lingüística perceptiva ed alla sua possibile applicazione all'acquisizione dello spagnolo come L2.
Ergosterol biosynthesis: a fungal pathway for life on land?
2012
International audience; Sterols, essential lipids of most eukaryotic cells, ensure important structural and signaling functions. The selection pressure that has led to different dominant sterols in the three eukaryotic kingdoms remains unknown. Here, we investigated the influence of the progression in the different steps of the ergosterol biosynthetic pathway (EBP) on the yeast resistance to transitions from aqueous to aerial media, typical perturbations of the higher fungi habitats. Five mutants of the EBP (ergΔ), accumulating different sterol intermediates in the EBP, and the wild-type (WT) strain were exposed to drying under atmospheric air or nitrogen and wetting. Results show that the …
Le filtre de Kalman étendu à grand-gain adaptatif et ses applications
2010
The work concerns the “observability problem”—the reconstruction of a dynamic process’s full state from a partially measured state— for nonlinear dynamic systems. The Extended Kalman Filter (EKF) is a widely-used observer for such nonlinear systems. However it suffers from a lack of theoretical justifications and displays poor performance when the estimated state is far from the real state, e.g. due to large perturbations, a poor initial state estimate, etc. . . We propose a solution to these problems, the Adaptive High-Gain (EKF). Observability theory reveals the existence of special representations characterizing nonlinear systems having the observability property. Such representations ar…
Desiccation and osmotic stress increase the abundance of mRNA of the tonoplast aquaporin BobTIP26-1 in cauliflower cells.
1999
Changes in vacuolar structure and the expression at the RNA level of a tonoplast aquaporin (BobTIP26-1) were examined in cauliflower (Brassicaoleracea L. var. botrytis) under water-stress conditions. Gradual drying out of slices of cauliflower floret tissue caused its collapse, with a shrinkage in tissue and cell volumes and an apparent vesiculation of the central vacuole, whereas osmotic stress resulted in plasmolysis with a collapse of the cytoplasm and the central vacuole within. Osmotic stress caused a rapid and substantial increase in BobTIP26 mRNA in slices of floret tissue. Exposure of tissue slices to a regime of desiccation showed a slower but equally large rise in BobTIP26 mRNA fo…