Search results for "iNOS"
showing 10 items of 2075 documents
Aproximacion funcional a CERKL, un gen causante de la retinosis pigmentaria, mediante el estudio de la localización intracelular de la proteína y la …
2015
La proteína CERKL se encuentra localizada tanto en el núcleo como en el citoplasma. En el citoplasma, CERKL se distribuye de manera difusa y también formando unos agregados que en su mayor parte se distribuyen en la periferia nuclear. Esos agregados colocalizan con marcadores de gránulos de estrés y su cantidad aumenta sometiendo las células a estrés (arsenito de sodio o choque térmico) y disminuye tras un tratamiento con cicloheximida (un inhibidor de la síntesis de proteínas que desensambla los gránulos de estrés). La entrada y salida de CERKL del núcleo es necesaria para su localización en los gránulos de estrés y, por eso, el mutante patológico C125W que está ausente de los núcleos no c…
Naso e dintorni
2009
Il termine di rinosinusite individua uno stato di flogosi della mucosa del naso e dei seni paranasali. Questa terminologia nasce dalla considerazione che la mucosa nasale e sinusale sono un’unica entità anatomo-funzionale, e supera così i vecchi concetti di “rinite” e “sinusite”. La rinosinusite è una patologia che colpisce un numero elevato di persone, sia adulti che bambini e ha mostrato un incremento d’incidenza progressivo negli ultimi anni parallelamente alla diffusione dell’allergopatia. Attualmente viene stimata una prevalenza di malattia del 14% circa nella popolazione generale. Di fatto il disturbo rinosinusale rappresenta uno dei principali motivi di consultazione del Medico di Me…
Quasi-periodic dipping in the ultraluminous X-ray source, NGC 247 ULX-1
2021
Most ultraluminous X-ray sources (ULXs) are believed to be stellar mass black holes or neutron stars accreting beyond the Eddington limit. Determining the nature of the compact object and the accretion mode from broadband spectroscopy is currently a challenge, but the observed timing properties provide insight into the compact object and details of the geometry and accretion processes. Here we report a timing analysis for an 800 ks XMM-Newton campaign on the supersoft ultraluminous X-ray source, NGC 247 ULX-1. Deep and frequent dips occur in the X-ray light curve, with the amplitude increasing with increasing energy band. Power spectra and coherence analysis reveals the dipping preferential…
rhoB encoding a UV-inducible Ras-related small GTP-binding protein is regulated by GTPases of the Rho family and independent of JNK, ERK, and p38 MAP…
1998
The small GTPase RhoB is immediate-early inducible by DNA damaging treatments and thus part of the early response of eukaryotic cells to genotoxic stress. To investigate the regulation of this cellular response, we isolated the gene for rhoB from a mouse genomic library. Sequence analysis of the rhoB gene showed that its coding region does not contain introns. The promoter region of rhoB harbors regulatory elements such as TATA, CAAT, and Sp1 boxes but not consensus sequences for AP-1, Elk-1, or c-Jun/ATF-2. The rhoB promoter was activated by UV irradiation, but not by 12-O-tetradecanoylphorbol-13-acetate treatment. rhoB promoter deletion constructs revealed a fragment of 0.17 kilobases in …
Search for transient sources with the ANTARES and KM3NeT neutrino telescopes in the multi-messenger astronomy era
2020
En el presente manuscrito se expone el trabajo realizado en el seno de la Collaboración ANTARES-KM3NeT sobre la astronomía multi-mensanjero con neutrinos, que se ha enfocado en dos ejes: la detección de neutrinos de supernova a bajas energías (MeV) con los telecopios KM3NeT y la búsqueda de neutrinos de alta energía (TeV-PeV) en ANTARES en coincidencia con fuentes transitorias detectadas en ondas gravitationales o rayos gamma de muy alta energía O(TeV). El primer análisis, explora la capacidad de los telescopios de neutrinos KM3NeT para detectar la señal de una explosión de supernova (CCSN), así como el potencial de explotar dicha detección para aprender sobre la física que hay detrás, en p…
THE LINKAGE BETWEEN UPPER RESPIRATORY TRACT INFECTIONS AND OTITIS MEDIA: EVIDENCE OF THE 'UNITED AIRWAYS CONCEPT'
2012
Upper respiratory tract infection (URTI) is a nonspecific term used to describe acute infections involving the nose, paranasal sinuses, pharynx and larynx and resulting from interplay between microbial load (viral and bacterial) and immune response. Infant and young children are prone to developing upper respiratory tract infections, which often result in bacterial complications especially acute otitis media because of the passage of bacteria (colonizing the nasopharynx) in the middle ear via Eustachian tube.
Aizvietotu cikloheksānu saturošu β-aminospirtu sintēze
2022
Maģistra darba literatūras apskata daļā apkopota informācija par β-adrenerģiskajiem receptoriem, to bioloģisko lomu, uzbūvi. Darbā apskatīta dažādu β-adrenerģisko receptoru agonistu uzbūve un to potenciālais pielietojums 2. tipa diabēta un aptaukošanās ārstēšanā. Darbā apskatītas epoksīdu aminolīzes reakcijas, Van Leusen reakcija un organocērija savienojumu pielietojums nitrilu dialkilēšanas reakcijās kā arī Ritera (Ritter) reakcija. Literatūras apskats satur informāciju, kas publicēta no 1954. gada līdz 2021. gadam, un iegūta, izmantojot datu bāzes Scopus, ScienceDirect un citas interneta datu bāzes. Darba gaitā tika sintezēti 26 jauni cikloheksānu saturoši β-aminospirti. Iegūtajiem savien…
Chemical effect on the XPS spectra of the valence band and on O KLL and Pd MNN Auger spectra in pumice-supported catalysts
1992
X-ray photoelectron spectra of the valence band and X-ray-excited O KLL Auger transition of pumice-supported Pd and Pt catalysts have been obtained and compared to the corresponding spectra of pumice (a naturally occurring amorphous aluminosilicate). The changes observed indicate interaction between metal and support. The valence region of the catalysts consists of three large peaks: one due to the d band of the metals and the other to the O 2p non-bonding orbitals and bonding-type orbitals formed by a mixing of the atomic orbitals (O 2p, Si 3s and Si 3p) of oxygen and silicon from the support. The intensity decrease of the component due to the bonding orbitals, observed in the catalyst spe…
Gendered Pathways Toward STEM Careers: The Incremental Roles of Work Value Profiles Above Academic Task Values.
2018
Drawing on Eccles’ expectancy-value model of achievement-related choices, we examined how work values predict individual and gender differences in sciences, technology, engineering, and math (STEM) participations in early adulthood (ages of 25/27, 6 or 8 years after postsecondary school), controlling for subjective task values attached to academic subjects in late adolescence (11th grade, age 18). The study examined 1,259 Finnish participants using a person-oriented approach. Results showed that: (a) we could identify four profile groups based on five core work values (society, family, monetary, career prospects, and working with people); (b) work-value profiles predicted young adults actua…
Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis
2011
Fibronectin (FN) is a major component of the extracellular matrix and functions in cell adhesion, cell spreading and cell migration. In the retina, FN is transiently expressed and assembled on astrocytes (ACs), which guide sprouting tip cells and deposit a provisional matrix for sprouting angiogenesis. The precise function of FN in retinal angiogenesis is largely unknown. Using genetic tools, we show that astrocytes are the major source of cellular FN during angiogenesis in the mouse retina. Deletion of astrocytic FN reduces radial endothelial migration during vascular plexus formation in a gene dose-dependent manner. This effect correlates with reduced VEGF receptor 2 and PI3K/AKT signalli…