Search results for "iNOS"
showing 10 items of 2075 documents
Tavallisen ihmisen uskottavuus mainoksen suosittelijana ja uskottavuuden vaikutus asenteeseen mainosta ja brandia kohtaan
2012
Tutkimuksen tavoitteena oli tutkia tavallisten ihmisten käyttöä mainoksen suosittelijoina, tavallisen ihmisen uskottavuutta suosittelijana ja uskottavuuden vaikutusta asenteeseen mainosta ja brandia kohtaan. Aikaisempaa tutkimusta aiheesta löytyi melko vähän, joten teoriapohjana käytettiin source credibility –teoriaa, jota on käytetty julkisuuden henkilöitä mainosten suosittelijoina tutkittaessa. Muiden aikaisempien tutkimustulosten perusteella mallia muokattiin niin, että tavallisen ihmisen uskottavuus suosittelijana oletettiin muodostuvan luotettavuudesta, asiantuntijuudesta ja samankaltaisuudesta. Tutkimukseen valittiin kolme erilaista, ulkonäköön liittyvää mainosta, joissa suosittelijoi…
Soiko yritysbrändi? : kuuntelukontekstin vaikutus äänilogojen välittämiin merkityksiin
2015
Tässä tutkimuksessa tarkasteltiin äänilogojen havaitsemista ja niiden viestinnällistä potentiaalia äänibrändäyksen kontekstissa. Äänilogo on käsitteenä melko uusi ja sillä tarkoitetaan visuaalista logoa vastaavaa tilausteoksena tuotettua lyhyttä äänellistä tunnistetta, jota organisaatiot voivat hyödyntää viestinnässään hyvin erilaisissa viestintäkanavissa ja ympäristöissä. Tutkimuksessa pyrittiin sekä kartoittamaan äänilogojen havaitsemista yleisellä tasolla että problematisoimaan äänibrändäysalan toimijoiden olettamusta siitä, että äänilogot voivat onnistuneesti välittää tiettyjä ominaisuuksia edustamastaan brändistä. Lisäksi selvitettiin erityisesti sitä, millä tavoin brändikonteksti eli …
Radiative neutrino masses: A window to new physics
2021
Currently, the Standard Model of particle physics (SM) is the best theory we have to describe particles and their interactions. However, there is evidence of physics beyond it, which motivates us to seek for a more complete theory. Neutrino oscillations constitute the first experimental confirmation of new physics, as they require a new piece that is absent in the SM, non-zero neutrino masses. Neutrino masses brought new theoretical challenges, for instance questions as how these masses are generated or why are they so small compared to other masses, are still under investigation. In this thesis, we aim to study radiative neutrino mass models, a class of models where small neutrino masses a…
Proximal Tibiofibular Joint Reconstruction With Autogenous Semitendinosus Tendon Graft
2013
Isolated and chronic anterolateral instability of the proximal tibiofibular joint (TFJ) is an uncommon condition, generally linked to an unrecognized or unhealed dislocation of the TFJ. Clinically, abnormal anterior movement of the head of the fibula is detected. In acute injuries conservative management should be preferred, whereas surgical treatment have been advocated in patients with chronic TFJ instability. Authors describe a new surgical reconstruction technique for chronic instability of the proximal TFJ using an autogenous semitendinosus tendon. The graft is passed through fibular and tibia tunnels and fixed with 2 interference screws. The tibial tunnel is reamed from the posterolat…
Diagnosis of the neuronal ceroid lipofuscinoses: An update
2006
Abstract For the majority of families affected by one of the neuronal ceroid lipofuscinoses (NCLs), a biochemical and/or genetic diagnosis can be achieved. In an individual case this information not only increases understanding of the condition but also may influence treatment choices and options. The presenting clinical features prompt initial investigation and also guide clinical care. The clinical labels “infantile NCL”, “late infantile NCL” and “juvenile NCL”, therefore remain useful in practice. In unusual or atypical cases ultra-structural analysis of white blood cells or other tissue samples enables planning and prioritisation of biochemical and genetic tests.This review describes cu…
Low-generation dendrimers with a calixarene core and based on a chiral C2-symmetric pyrrolidine as iminosugar mimics
2012
The preparation of low-generation dendrimers based on a simple calix[4]arene scaffold by insertion of the iminosugar-analogue C2-symmetric 3,4-dihydroxypyrrolidine is described. This methodology allows a rapid incorporation of a considerable number of iminosugar-like moieties in a reduced volume and in a well-defined geometry. The inclusion of alkali-metal ions (sodium and potassium) in the polar cavity defined by the acetamide moieties at the lower rim of the calixarene was demonstrated, which allows also the rigidification of the dendrimer structure and the iminosugar presentation in the clusters. The combination of the supramolecular properties of calixarenes with the advantage of a dend…
Patrón de las alteraciones dentales asociadas a la impactación del canino maxilar por palatino
2015
La tesis doctoral se ha realizado para poder encontrar un método de diagnóstico precoz de la impactación del canino maxilar por palatino, mediante la detección temprana de otras alteraciones dentales asociadas y así poder aplicar tratamientos tempranos, que mejoren el pronóstico de la impactación del canino maxilar por palatino. La impactación del canino maxilar por palatino, supone la alteración del trayecto eruptivo del mismo, que lo conduce a la zona palatina. Los pacientes con esta alteración necesitan tratamiento de ortodoncia para reposicionar el canino en la arcada, que suele ser largo y complejo. A raíz del síndrome DAP (Dental Anomaly Patterns), se ha visto que esta alteración pued…
Predicción de la Inclusión de Caninos Superiores en una Población Infantil
2015
La tesis doctoral se ha realizado debido a la gran prevalencia de inclusión de caninos superiores en la población general. En la segunda fase de recambio dentario, el diente que provoca más problemas eruptivos es el canino permanente superior. Si este diente altera su trayecto eruptivo, el resultado puede ser una erupción ectópica del mismo o su retención por palatino. En ambos casos, el paciente necesitará tratamiento ortodóncico que suele ser largo y complejo. Por ese motivo, sería importante poder predecir la inclusión del canino permanente superior. OBJETIVOS: En cuanto a los objetivos de la tesis, queríamos desarrollar un método preciso para medir con exactitud la angulación del canino…
Repression of Human Papillomavirus Oncogene Expression under Hypoxia Is Mediated by PI3K/mTORC2/AKT Signaling
2019
Oncogenic HPV types are major human carcinogens. Under hypoxia, HPV-positive cancer cells can repress the viral E6/E7 oncogenes and induce a reversible growth arrest. This response could contribute to therapy resistance, immune evasion, and tumor recurrence upon reoxygenation. Here, we uncover evidence that HPV oncogene repression is mediated by hypoxia-induced activation of canonical PI3K/mTORC2/AKT signaling. AKT-dependent downregulation of E6/E7 is only observed under hypoxia and occurs, at least in part, at the transcriptional level. Quantitative proteome analyses identify additional factors as candidates to be involved in AKT-dependent E6/E7 repression and/or hypoxic PI3K/mTORC2/AKT ac…
Influence of Sodium on the Structure and HDS Activity of Co–Mo Catalysts Supported ON Silica and Aluminosilicate
2000
Abstract Structural changes and catalytic performances of hydrodesulfurization (HDS) Co–Mo catalysts, supported on amorphous aluminosilicate (ASA) and amorphous SiO 2 were investigated as a function of the amount of sodium ions added to the supports. The catalysts were prepared according to the incipient wet impregnation method using (NH 4 ) 6 Mo 7 O 24 as molybdenum precursor and CoCl 2 or Co(NO 3 ) 2 as cobalt precursor. Structural and morphological characterisations of the materials were performed with X-ray diffraction (XRD) and surface area measurements (BET). In the case of the ASA-supported catalysts, increasing the amount of sodium resulted in a gradual decrease of the catalyst surf…