Search results for "iNOS"
showing 10 items of 2075 documents
Immunoaffinity purification and characterization of mitochondrial membrane-bound D-3-hydroxybutyrate dehydrogenase from Jaculus orientalis.
2008
Abstract Background The interconversion of two important energy metabolites, 3-hydroxybutyrate and acetoacetate (the major ketone bodies), is catalyzed by D-3-hydroxybutyrate dehydrogenase (BDH1: EC 1.1.1.30), a NAD+-dependent enzyme. The eukaryotic enzyme is bound to the mitochondrial inner membrane and harbors a unique lecithin-dependent activity. Here, we report an advanced purification method of the mammalian BDH applied to the liver enzyme from jerboa (Jaculus orientalis), a hibernating rodent adapted to extreme diet and environmental conditions. Results Purifying BDH from jerboa liver overcomes its low specific activity in mitochondria for further biochemical characterization of the e…
Cycloartane Glycosides from Astragalus erinaceus
2012
WOS: 000306925400004
IL-12 Expands and Differentiates Human Vγ2Vδ2 T Effector Cells Producing Antimicrobial Cytokines and Inhibiting Intracellular Mycobacterial Growth
2019
While IL-12 plays a key role in differentiation of protective CD4+ Th1 response, little is known about mechanisms whereby IL-12 differentiates other T-cell populations. Published studies suggest that predominant Vγ2Vδ2 T cells in humans/nonhuman primates (NHP) are a fast-acting T-cell subset, with capacities to rapidly expand and produce Th1 and cytotoxic cytokines in response to phosphoantigen (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) produced by Mycobacterium tuberculosis (Mtb) or others. However, whether IL-12 signaling pathway mediates fast-acting and Th1 or anti-microbial features of Vγ2Vδ2 T cells remains poorly defined. Here, we show that IL-12, but not other IL-12 fami…
Macrophage: SHIP of Immunity
2014
Immunology. Why does it exist? Two words. Cure disease. People get diseases. “Test tubes” do not. People fund immunologists for solutions to their health problems. But, immunologists often study leukocytes in test tubes – the laboratory – away from diseases. Why? Because much can be learned from analyzing cellular biochemistry and behaviors in vitro that cannot be ascertained when leukocytes are in animals. At the same time, isolated leukocyte reactions often do not reflect how the immune system operates as a unit. So, it is critical to verify in vitro observations in vivo. Among leukocytes, macrophages are the central initiating and directing element in immune systems, and serve this role …
Una cort "ferraresa" a València: els Centelles, Ariosto i un programa de substitució de la tradició literària autòctona
2003
Through a rhyming catalogue of Valencian writers included in his «Segunda parte de Orlando» (Second part of Orlando) (1555) and through other verses in the work, Nicolau Espinosa argues in favour of a cultured literary tradition in a new language, Castilian Spanish. Moreover, the intention to identify the patronage of the dukes of Oliva with that of the dukes of Ferrara, through skilful parallels between Ariosto’s «Orlando» and Espinosa’s composition can be clearly seen.
A reappraisal of the purported gastric pellet with Pterosaurian bones from the Upper Triassic of Italy
2015
A small accumulation of bones from the Norian (Upper Triassic) of the Seazza Brook Valley (Carnic Prealps, Northern Italy) was originally (1989) identified as a gastric pellet made of pterosaur skeletal elements. The specimen has been reported in literature as one of the very few cases of gastric ejecta containing pterosaur bones since then. However, the detailed analysis of the bones preserved in the pellet, their study by X-ray microCT, and the comparison with those of basal pterosaurs do not support a referral to the Pterosauria. Comparison with the osteology of a large sample of Middle-Late Triassic reptiles shows some affinity with the protorosaurians, mainly with Langobardisaurus pand…
Theoretical estimates of supernova-neutrino cross sections for the stable even-even lead isotopes: Charged-current reactions
2016
A detailed study of the charged-current supernova electron neutrino and electron antineutrino scattering off the stable even-mass lead isotopes A = 204, 206, and 208 is reported in this work. The proton-neutron quasiparticle random-phase approximation (pnQRPA) is adopted to construct the nuclear final and initial states. Three different Skyrme interactions are tested for their isospin and spin-isospin properties and then applied to produce (anti)neutrino-nucleus scattering cross sections for (anti)neutrino energies below 80 MeV. Realistic estimates of the nuclear responses to supernova (anti)neutrinos are computed by folding the computed cross sections with a two-parameter Fermi-Dirac distr…
Theoretical study of supernova neutrino and antineutrino scattering off the stable cadmium and lead isotopes
2017
In this thesis work, an extensive study of neutrino- and antineutrino-nucleus interactions is performed. The work is focused on supernova-neutrino scattering off the stable cadmium and lead isotopes. The studied nuclei are of interest for the investigations of neutrino-properties and for neutrino-detection experiments. The adopted nuclear-structure models are based on the quasiparticle random-phase approximation (QRPA) and the microscopic quasiparticle- phonon model (MQPM) and the cross-sections calculations are based on the Donnelly-Walecka formalism. The computed cross sections are folded with a two-parameter Fermi-Dirac distribution to obtain realistic estimates of the nuclear responses …
LeptoGen-koodi
2021
LeptoGen is a software package for numerically solving (resonant) leptogenesis equations including full flavour coherence information for the Majorana neutrinos. The package is written in Wolfram Language and can be run in the Mathematica front end. (Tested in Mathematica 12.0.) For usage license, see the attachment.
Breaking of discrete symmetries and global lepton number in neutrino physics
2019
En relación con principios de simetría, esta Tesis ha abordado una serie de preguntas abiertas fundamentales en física de neutrinos. Por un lado, la existencia de violación de CP genuina en el sector leptónico, bajo el problema histórico de la falsa violación de CP inducida por la propagación de neutrinos en materia, que también conduce a la discriminación de la jerarquía en el ordenamiento de masas de los neutrinos. Demostramos que, en cualquier transición de sabor, las asimetrías que violan CP, T y CPT en oscilaciones de neutrinos en materia pueden escribirse en términos de una base de tres componentes independientes: (a) la genuina CPT-par, no nula sii hay violación genuina de CP ; (b) l…