Search results for "iOS"

Regulation of Protein-DNA Interactions at the Interferon-gamma Gene Promoter by Corticosteroids: Implications for Inflammatory Bowel Diseases

1998

Inhibition of anti-GD3-ganglioside antibody-induced proliferation of human CD8+ T cells by CD16+ natural killer cells

1994

The ganglioside GD3 has been described as a membrane component of human T cells which is involved in T cell growth. In the present study the activating function of GD3 for human CD4+ and CD8+ T cells was analyzed by five different monoclonal antibodies (mAb) directed against the GD3 molecule. Three mAb U5, Z21 and R24 induced strong proliferation of peripheral blood mononuclear cells and purified CD8+ and CD4+ T cells of normal donors containing less than 5% CD16+ natural killer (NK) cells. In contrast to CD4+ T cells, CD8+ T cells proliferated only weakly in the presence of 15% CD16+ NK cells. The proliferative response of purified CD4+ and CD8+ T cells (< 5% NK cells) correlated with the …

Isolation of Differentially Expressed Genes in Epidermal Langerhans Cells

1997

Epidermal Langerhans cells (LC) represent immature dendritic cells (DC) resident in the skin, which are not yet able to prime naive T cells1. In vitro cultivation of LC in the presence of keratinocytes, supplying survival and differentiation signals, induces maturation events in LC2. These are highlighted by the downregulation of the biosynthesis of MHC class II molecules3, by the upregulation of the surface expression of adhesion and costimulatory molecules like CD80, CD86, CD54 and CD584,5, and by the acquisition of a potent immunostimulatory capacity for T cells6. Mature LC are potent inducers of naive T cells. Thus LC represent an ideal model system to investigate the maturation of DC (…

Migraciones y progreso

2008

L'acacia au Sénégal

1996

La biodiversité des Glomales associés à #Acacia albida$ est étudiée en fonction de l'âge de l'arbre, des saisons et des propriétés physicochimiques du sol. Les Glomales sont récoltées jusqu'à 1,5 et 4,5 m dans les régions soudano-guinéennes et jusqu'à 16 et 35 m dans les régions sahéliennes. La culture in vitro de la forme intraracinaire des Glomales en présence de racines isolées a montré une diversité morphologique des souches. En complément à cette taxonomie morphologique, des marqueurs moléculaires ont permis d'étudier la variabilité génétique des Glomales en comparant les variations de séquences d'ADN extrait de spores et de fragments mycorhiziens. (Résumé d'auteur)

Epidemiologia delle Malattie Cardiovascolari

2004

Vissuti controtransferali degli psicoterapeuti che hanno in carico pazienti appartenenti al mondo mafioso

2008

Impact of the Coronavirus pandemic on the economic development of Ukraine and Latvia

2021

The COVID-19 pandemic that has swept the world has created a number of diverse threats to the development of the countries’ economies, including Ukraine and Latvia. An adequate assessment of these threats is very difficult and, moreover, often has a probabilistic character due to their singularity and novelty. The COVID-19 crisis mainly affected the tertiary sector, in particular companies involved in tourism, international passenger transport, accommodation, catering, entertainment, and cultural events, where demand fell sharply, and jobs fell. They were also followed by a contraction in demand in the manufacturing and transport sectors, which were mainly oriented towards external demand a…

Fast evaluation of enantioselective drug metabolism by electrophoretically mediated microanalysis: application to fluoxetine metabolism by CYP2D6.

2013

In this work, a capillary electrophoretic methodology for the enantioselective in vitro evaluation of drugs metabolism is applied to the evaluation of fluoxetine (FLX) metabolism by cytochrome 2D6 (CYP2D6). This methodology comprises the in-capillary enzymatic reaction and the chiral separation of FLX and its major metabolite, norfluoxetine enantiomers employing highly sulfated β-CD and the partial filling technique. The methodology employed in this work is a fast way to obtain a first approach of the enantioselective in vitro metabolism of racemic drugs, with the additional advantage of an extremely low consumption of enzymes, CDs and all the reagents involved in the process. Michaelis-Men…

Effects of sample pretreatment and external contamination on bivalve shell and Carrara marble δ18O and δ13C signatures

2017

Abstract Stable isotope signatures of bivalve shells serve as important paleoclimate proxies. However, such data can be biased as a consequence of physical and chemical sample pretreatment and contamination during sampling. As yet, the potential isotope error induced by paleontological preservation techniques and specific methods used in bivalve sclerochronology have not been systematically assessed. To address these issues, homogenized powder of a well-preserved, aragonitic fossil shell, Glycymeris obovata (ca. 30 Ma old) as well as Carrara marble powder (calcite) were exposed to ultrasound, a set of different staining solutions and cleaning agents. In addition, these reference materials w…