Search results for "ibers"
showing 10 items of 578 documents
In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function.
2008
Aim Drug-eluting stents are widely used to prevent restenosis but are associated with late endothelial damage. To understand the basis for this effect, we have studied the consequences of a prolonged incubation with rapamycin on the viability and functions of endothelial cells. Methods and results Human umbilical vein or aorta endothelial cells were exposed to rapamycin in the absence or in the presence of tumour necrosis factor α (TNFα). After a 24 h-incubation, rapamycin (100 nM) caused a significant cell loss associated with the increase of both apoptosis and necrosis, as quantified by propidium iodide staining, caspase 3 activity, and lactate dehydrogenase release. Rapamycin also impair…
Resveratrol initiates differentiation of mouse skeletal muscle-derived C2C12 myoblasts.
2012
Resveratrol is one of the most widely studied bio-active plant polyphenols. While its effect on endothelial blood vessel cells, cancer cells, inflammatory processes and neurodegenerative events is well documented, little is known about the implication of this phytophenol in differentiating processes, particularly in skeletal muscle cells. Here, we report the effects of resveratrol on mouse skeletal muscle-derived cells (C2C12) in either a nondifferentiated (myoblasts) or differentiated state (myotubes) by evaluating resveratrol uptake, cell proliferation, changes in cell shape, and the expression of genes encoding muscle-specific transcription factors or contractile proteins. Resveratrol: (…
The human factor in cybersecurity: An experimental approach to cyber-risk and cyberinsurance
2021
Este trabajo de investigación tiene como objetivo el desarrollo y validación experimental de modelos conductuales, con sólido fundamento teórico, capaces de explicar y prever la adopción de ciberseguro, así como los de los elementos clave de ciberseguridad detrás de dicha adopción. Con este fin, la presente disertación se centra en tres dimensiones clave en ciberseguridad: ciberseguro (adopción de productos de seguros que cubren parcialmente el impacto de posibles ataques), ciberprotección (adopción de medidas capaces de reducir el riesgo de sufrir un ataque) y comportamiento online (nivel de riesgo asumido por los usuarios cuando navegan en Internet). Estas dimensiones recogen aspectos con…
Multicore Fiber Opportunities for Centralized Radio Access Networks
2014
Les arquitectures de ràdio sobre fibra concebudes per a la propera generació de sistemes d’accés sense fils es basen en xarxes d’accés a ràdio centralitzades (C-RAN), on els recursos de processament de banda base corresponents a diferents estacions base remotes (BS) s’allotgen en una oficina central compartida (CO). Proposem l'explotació de les característiques úniques que aporta el paral·lelisme inherent de les fibres de diversos nuclis com a solució compacta per implementar la connectivitat CO-BS necessària en C-RAN. JCI-2012-14805 PROMETEO II/2013/012 Radio-over-fiber architectures conceived for the next generation of wireless access systems are based on Centralized Radio Access Networks…
Alix protein is substrate of Ozz-E3 ligase and modulates actin remodeling in skeletal muscle
2012
Alix/AIP1 is a multifunctional adaptor protein that participates in basic cellular processes, including membrane trafficking and actin cytoskeleton assembly, by binding selectively to a variety of partner proteins. However, the mechanisms regulating Alix turnover, subcellular distribution, and function in muscle cells are unknown. We now report that Alix is expressed in skeletal muscle throughout myogenic differentiation. In myotubes, a specific pool of Alix colocalizes with Ozz, the substrate-binding component of the muscle-specific ubiquitin ligase complex Ozz-E3. We found that interaction of the two endogenous proteins in the differentiated muscle fibers changes Alix conformation and pro…
Practical design rules for single-channel ultra high-speed dense dispersion management telecommunication systems
2009
International audience; In this work, we establish some efficient and practical design rules for the implementation of single-channel ultra-high speed (>160-Gbit/s) telecommunication systems based on dense dispersion management. Moreover, we analyze some of actual implementation issues such as slope compensation scenario, junction losses, polarization mode dispersion and chromatic dispersion fluctuations.
Nexus of Electrospun Nanofibers and Additive Processing—Overview of Wearable Tactical Gears for CBRNE Defense
2021
Due to complex nature of twenty-first century battlefield, soldiers must perform multiple tasks to protect nations while maintaining their own safety. Advances in technological innovations are critical to support such functionalities to enhance safety and security. Using nexus of electrospinning and additive processing, we present how recent developments can be used to produce new generation of protective fabrics with integrative force protection, sensing/detection of chemical, biological, radiological, nuclear, and high yield explosives (CBRNE), and biomedical functionalities. Although electrospinning has been in use for some time, the special blends and configurations of nanofibers, as de…
Vesamicol blocks the recovery, by recycling cholinergic electromotor synaptic vesicles, of the biophysical characteristics of the reserve population.
1993
The effect of vesamicol on the ability of recycling cholinergic synaptic vesicles to recover, during a period of post-stimulation rest, the biophysical properties of the reserve pool was studied in prestimulated perfused blocks of the electric organ of the electric ray, Torpedo marmorata, a tissue rich in cholinergic synapses. The effect of the drug was analysed by high-resolution centrifugal density-gradient fractionation in a zonal rotor of the extracted vesicles. The two vesicle fractions were identified by their ATP and acetylcholine content and the recycled vesicles by their acquisition of [3H]acetylcholine derived from [3H]acetate in the perfusate. Vesamicol (10 microM) blocked the up…
Sources optiques infrarouges impulsionnelles ultra-courtes et spectralement ultra-larges générées par effet Raman dans les fibres creuses
2019
Gas-filled Hollow-Core Photonic Crystal Fibers (HC-PCF) are efficient tools regarding ultra-wide and coherent optical frequency combs by Stimulated Raman Scattering (SRS). Coherence is reached thanks to highly transient regime as it allows amplification, from quantum to macroscopic level, of a unique spatial and temporal mode (TSM). This results in the generation of Stokes waves with a well-determined phase. The present work details on which time scale coherence can subsist, between two consecutive pulses. The possibility of making a new kind of mode-lock is studied. Then the extreme versatility of gas-filled HC-PCF is illustrated by presenting different kind of new laser sources, exploitin…
Irreducible components of Hurwitz spaces of coverings with two special fibers
2013
In this paper we prove new results of irreducibility for Hurwitz spaces of coverings whose monodromy group is a Weyl group of type B_d and whose local monodromies are all reflections except two.