Search results for "idia"
showing 10 items of 673 documents
2-(4-Toluidino)pyrimidine
1984
Aus der Kondensation von 4-Tolylguanidin (1) mil den β-Diketonen 2a-g gehen die 2-(4-Toluidino)pyrimidine 3a-g hervor, unter denen sich Vertreter mit antidiabetischer und antimykotischer Wirksamkeit befinden. Antidiabetic Agents, II: 2-(4-Toluidino)pyrimidines Condensations of 4-tolylguanidine (1) with the β-diketones 2a-g yield the 2-(4-toluidino)pyrimidines 3a-g which comprise compounds exhibiting antidiabetic and antimycotic activities.
Il diritto penale tra esigenze di tutela e principio di sussidiarietà: la coperta è (sempre) troppo corta?
2018
Si tratta della Relazione su “Il diritto penale tra esigenze di tutela e principio di sussidiarietà: la coperta è (sempre) troppo corta?", nel Convegno su «I nuovi confini del diritto penale», organizzato dal Centro Siciliano di Studi sulla Giustizia, tenutosi a Palermo il 6 maggio 2016, nell'Aula Magna del Palazzo di Giustizia.
Local oropharyngeal side effects of inhaled corticosteroids in patients with asthma.
2006
The widespread use of inhaled corticosteroids (ICS) for the treatment of persistent asthma, although highly effective, may be associated with both systemic and local side effects. Systemic side effects of ICS have been extensively studied. In contrast, relatively few studies have been performed to specifically evaluate local side effects of ICS. These local side effects--including oropharyngeal candidiasis, dysphonia, pharyngitis, and cough--are generally viewed as minor complications of therapy. However, they can be clinically significant, affect patient quality of life, hinder compliance with therapy, and mask symptoms of more serious disease. Local side effects result from deposition of …
Review of the safety, tolerability, and drug interactions of the new antifungal agents caspofungin and voriconazole
2003
Managing invasive fungal infections often presents a challenge for clinicians in the treatment of immunocompromised patients. Two very different systemic antifungal agents, voriconazole and caspofungin, have recently been introduced into the market place. Voriconazole is a new triazole antifungal, while caspofungin is the first echinocandin antifungal. Voriconazole acts by inhibiting the synthesis of ergosterol in the fungal cell membrane. Caspofungin inhibits beta-1,3-D-glucan synthesis in the cell wall, a target present in fungal cells, but absent from mammalian cells. Both agents are broad-spectrum, with efficacy against invasive Aspergillus and Candida infections. The safety and tolerab…
Solid and Semisolid Innovative Formulations Containing Miconazole-Loaded Solid Lipid Microparticles to Promote Drug Entrapment into the Buccal Mucosa
2021
The currently available antifungal therapy for oral candidiasis (OC) has various limita- tions restricting its clinical use, such as short retention time, suboptimal drug concentration and low patients compliance. These issues could be overcome using micro or nanotechnology. In par- ticular, solid lipid microparticles (SLMs) resulted as a particularly promising penetration enhancer carrier for lipophilic drugs, such as the antifungal miconazole (MCZ). Based on these considera- tions, cetyl decanoate (here synthesized without the use of metal catalysis) was employed together with 1-hexadecanol to prepare MCZ-loaded SLMs. These resulted in a powder composed of 45–300 µm diameter solid spheric…
The Social State Based on the Rule of Law in the Europe of Rights
2012
Chapter 8 shows how the idea of the social State under the rule of law has been linked to the European Union since its inception. The founding fathers (Adenaeur, de Gasperi, Monet, Schuman) set the principles of dignity, freedom, equality and solidarity as a way of freeing European citizens from fear, misery and misfortune. Welfare is, above all, a state of justice that defines the threshold between indecency and well-being and affirms that human development is not (only) economic growth. Jacques Maritain, whose influence on the European Union is well known, proclaimed the order that contains the three principles of the social state: the primacy of the person, the priority of civil society …
Tributyltin chloride-induced effects on protein tyrosine phosphorylation and on extracellular-signal-regulated kinase (ERK) phosphorilation in Ascidi…
2011
Ascidians represent an intriguing candidate experimental system for studying the effects of environmental stress. We studied TBT effects and probable related pathways were investigated on ascidian embryos by using Western immunoblotting. Among the various signal transduction pathways involved in response to environmental stress, both tyrosine kinase signalling and MAPKs have been played a significant role. To better understand molecular mechanisms after exposure to TBT we studied the two signal transduction pathways above mentioned. Attempting to unravel the molecular effects of TBT-induced on ascidians embryogenesis, TBT treatments carried out in Phallusia mammillata embryos at gastrula st…
Effects of tributyltin chloride in ascidian embryos: modulation of kinase-mediated signalling pathways
2009
We studied the effects of various TBT concentrations by assaying the activity of ERK 1/2 (p44/42) and phospho-ERK1/2 (phospho-p44/42), proteins with a key role in ascidian development, and tyrosine kinase-dependent pathway. The effects of this xenobiotic and the role of some signalling mechanisms on ascidian embryos were examined by using Western immunoblotting. The tyrosine phosphorylation pattern in the ascidians Ciona intestinalis and Phallusia mammillata development was examined and different levels of protein phosphorylation were found as a response to TBT at μM range. To determine whether another key signalling pathway was activated, the effects of TBT on the phosphorylation state of …
The taxonomy ofOreosparte(Apocynaceae: Asclepiadoideae)
2013
Oreosparte is a monotypic genus described as bearing strong similarities to Hoya (Marsdenieae), but separated from it based on the presence of a campanulate corolla with a contracted throat and lanceolate, spreading lobes. Its type specimen was destroyed during the fire at the Berlin herbarium in 1943. So far no suitable lectotype or further specimens belonging to the taxon were located. We report the finding of one specimen of Oreosparte collected from the type locality, allowing the selection of a neotype, to provide an extended description, and discussion of the morphological affinities with Hoya. Based on its morphology, despite being probably closely related to Hoya, we suggest that Or…
Foreign Direct Investment Spillovers: Evidence from the British Retail Sector
2011
This paper discusses the impact of foreign-ownership presence on the productivity performance of British-owned domestic retailers. In particular, we analyse the existence of productivity spillovers, in the form of knowledge transfer, by using establishment-level data from the Annual Respondents Database over the period 1997–2003. The results confirm the presence of such spillovers and highlight their positive and significant impact on the productivity of domestic firms, although these spillovers are mostly confined to the region in which foreign subsidiaries locate. There is also evidence that the productivity benefit from regional foreign direct investment spillovers increases with the abs…