Search results for "immunoevasion"

showing 2 items of 2 documents

Current advances in γδ T cell-based tumor immunotherapy

2017

γδ T cells are a minor population (~5%) of CD3 T cells in the peripheral blood, but abound in other anatomic sites such as the intestine or the skin. There are two major subsets of γδ T cells: those that express Vd1 gene, paired with different Vγ elements, abound in the intestine and the skin, and recognize the major histocompatibility complex (MHC) class I-related molecules such as MHC class I-related molecule A, MHC class I-related molecule B, and UL16-binding protein expressed on many stressed and tumor cells. Conversely, γδ T cells expressing the Vδ2 gene paired with the Vγ9 chain are the predominant (50-90%) γδ T cell population in the peripheral blood and recognize phosphoant…

0301 basic medicinelcsh:Immunologic diseases. AllergyAdoptive cell transferadoptive transferT cellImmunologyReviewBiologyMajor histocompatibility complexγδ T cells03 medical and health sciencesInterleukin 210302 clinical medicineAdoptive transfer; Immunoevasion; Immunotherapy; Zoledronate; γδ T cells; Immunology and Allergy; ImmunologyMHC class ImedicineCytotoxic T cellImmunology and AllergyAdoptive transfer Immunoevasion Immunotherapy Zoledronate γδ T cellsGamma delta T cellγδ T cellMHC restriction030104 developmental biologymedicine.anatomical_structureImmunologybiology.proteinimmunoevasionimmunotherapylcsh:RC581-607030215 immunologyZoledronate
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Effects of B-Cell Lymphoma on the Immune System and Immune Recovery after Treatment: The Paradigm of Targeted Therapy

2022

B-cell lymphoma and lymphoproliferative diseases represent a heterogeneous and complex group of neoplasms that are accompanied by a broad range of immune regulatory disorder phenotypes. Clinical features of autoimmunity, hyperinflammation, immunodeficiency and infection can variously dominate, depending on the immune pathway most involved. Immunological imbalance can play a role in lymphomagenesis, also supporting the progression of the disease, while on the other hand, lymphoma acts on the immune system to weaken immunosurveillance and facilitate immunoevasion. Therefore, the modulation of immunity can have a profound effect on disease progression or resolution, which makes the immune syst…

immunosenescenceLymphoma B-CellimmunosuppressionLymphomaB-cell lymphomaOrganic ChemistryGeneral Medicineimmune recoverychemotherapytargeted therapyImmunotherapy AdoptiveLymphoproliferative DisordersCatalysisComputer Science ApplicationsCAR-TSettore MED/15 - Malattie Del SangueInorganic ChemistryImmune Systemimmune therapyTumor MicroenvironmentimmunoevasionHumansPhysical and Theoretical ChemistryMolecular BiologySpectroscopy
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