Search results for "import"
showing 10 items of 286 documents
Minimal clinically important difference and minimal detectable change of the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0…
2020
Objectives: The aim of this study is to estimate a minimal clinically important difference (MCID) and a minimal detectable change (MDC) of the 12-item WHODAS 2.0 amongst patients with chronic musculoskeletal pain. Design: Cross-sectional cohort study. Setting: Outpatient Physical and Rehabilitation Medicine clinic. Subjects: A total of 1988 consecutive patients with musculoskeletal pain. Interventions: A distribution-based approach was employed to estimate a minimal clinically important difference, a minimal detectable change, and a minimal detectable percent change (MDC%). Results: The mean age of the patients was 48 years, and 65% were women. The average intensity of pain was 6,3 (2.0) po…
¿Por qué la literatura?
2021
In poetry, as well as in a good part of prose works, the rhythm of words is the music that governs reason and emotion. Literature occupies an important place in my creation. In this article I describe the different procedures in which I configure its presence in my music and the main themes in four of my works: Envoi, Como el viento, Maya and Transmutación.
Cytoplasmic Parvovirus Capsids Recruit Importin Beta for Nuclear Delivery
2019
Parvoviruses are an important platform for gene and cancer therapy. Their cell entry and the following steps, including nuclear import, are inefficient, limiting their use in therapeutic applications. Two models exist on parvoviral nuclear entry: the classical import of the viral capsid using nuclear transport receptors of the importin (karyopherin) family or the direct attachment of the capsid to the nuclear pore complex leading to the local disintegration of the nuclear envelope. Here, by laser scanning confocal microscopy and in situ proximity ligation analyses combined with coimmunoprecipitation, we show that infection requires importin β-mediated access to the nuclear pore complex and …
The severe phenotype of Diamond-Blackfan anemia is modulated by heat shock protein 70.
2017
International audience; Diamond-Blackfan anemia (DBA) is a rare congenital bone marrow failure syndrome that exhibits an erythroid-specific phenotype. In at least 70% of cases, DBA is related to a haploinsufficient germ line mutation in a ribosomal protein (RP) gene. Additional cases have been associated with mutations in GATA1. We have previously established that the RPL11+/Mut phenotype is more severe than RPS19+/Mut phenotype because of delayed erythroid differentiation and increased apoptosis of RPL11+/Mut erythroid progenitors. The HSP70 protein is known to protect GATA1, the major erythroid transcription factor, from caspase-3 mediated cleavage during normal erythroid differentiation.…
Confirmatory factor analysis of the Patient Assessment of Constipation-Symptoms (PAC-SYM) among patients with chronic constipation.
2015
Background and aim: PAC-SYM is widely adopted to asses constipation severity. However, it has been validated in a small sample, few items have been included based on expert opinion and not on empirical grounds, and its factor structure has never been replicated. We aimed at evaluating the psychometric properties of PAC-SYM in patients with chronic constipation. Methods: We enrolled 2,203 outpatients with chronic constipation in two waves. We used wave I sample to test the psychometric properties of the PAC-SYM and wave II sample to cross-validate its factor structure, to assess criterion validity, responsiveness to clinical change, and its minimal clinically important difference. Results: O…
The Concordance between Teachers’ and Parents’ Perceptions of School Transition Practices: A Solid Base for the Future
2015
This study focuses on parents’ and teachers’ perceptions of practices aimed at easing the transition to formal schooling (e.g., familiarization with the school, discussions about the school entrants). A total of 230 preschool teachers, 131 elementary school teachers, and 2,662 mothers and fathers filled in a questionnaire containing items on how important they considered different preschool-school transition practices. The participants considered the various transition practices to be at least somewhat important. On average, familiarization with the school was considered to be most important, whereas teacher co-operation and joint writing of curricula were considered to be least important. …
Simúlidos (Diptera: Simuliidae) de los ríos de la Comunidad Valenciana: Implicaciones en la salud pública y su control
2018
Los simúlidos (Diptera: Simuliidae) se encuentran distribuidos por casi todo el mundo. Su presencia está ampliamente influenciada por la disponibilidad de cursos de agua con flujo, necesarios para el desarrollo de los estados inmaduros (ADLER & McCREADIE, 2002), ocupando ambientes que van desde cursos temporales hasta grandes ríos. Los simúlidos crían en aguas corrientes, se les puede encontrar tanto en arroyos y torrentes de montaña como en los lentos flujos de agua de los ríos en sus tramos bajos. Además, existen unas pocas especies las cuales se han adaptado a flujos de agua tan escasos donde incluso la corriente es casi imperceptible (BURGER, 1987). En cualquier caso, se sabe que cierto…
Avis en réponse à la saisine HCB - dossier C/NL/06/01_001. Paris, le 17 octobre 2018
2018
Le Haut Conseil des biotechnologies (HCB) a été saisi le 14 août 2018 par les autorités compétentes françaises (le ministère de l’Agriculture et de l’Alimentation) d’une demande d’avis relative au dossier C/NL/06/01_001 de demande de renouvellement d’autorisation de mise sur le marché de la lignée d’oeillets génétiquement modifiés 123.8.12 (identificateur unique FLO- 40689-6) à des fins d’importation et de commercialisation de fleurs coupées. Ce dossier a été déposé par la société Suntory Flowers Limited auprès des autorités compétentes néerlandaises sur le fondement de la directive 2001/18/CE. Conformément à cette directive, la Commission européenne a adressé le rapport d’évaluation des Pa…
Ārējās tirdzniecības problēmas Latvijā
2015
Maģistra darbā „Ārējās tirdzniecības problēmas Latvijā” tiek pētīti un salīdzināti Latvijas eksporta un importa dati. Maģistra darba mērķis ir, pamatojoties uz zinātnisko literatūru, normatīvo aktu izpēti un statistisko datu analīzi, sniegt ārējās tirdzniecības teorētisko pamatojumu, izanalizēt ārējās tirdzniecības dinamiku un struktūru Latvijā, kā arī veikt ārējās tirdzniecības problēmu analīzi Latvijas nozīmīgākajās nozarēs. Darba mērķa sasniegšanai galvenie darba uzdevumi: •pamatojoties uz zinātnisko literatūru, izpētīt starptautisko tirdzniecības vēsturi un to nozīmi mūsdienās; •izanalizēt Latvijas ārējās tirdzniecības dinamiku un struktūru un to svārstību ietekmējošos iemeslus; •izvirz…
Deregulated High Affinity Copper Transport Alters Iron Homeostasis inArabidopsis
2020
The present work describes the effects on iron homeostasis when copper transport was deregulated in Arabidopsis thaliana by overexpressing high affinity copper transporters COPT1 and COPT3 (COPTOE). A genome-wide analysis conducted on COPT1OE plants, highlighted that iron homeostasis gene expression was affected under both copper deficiency and excess. Among the altered genes were those encoding the iron uptake machinery and their transcriptional regulators. Subsequently, COPTOE seedlings contained less iron and were more sensitive than controls to iron deficiency. The deregulation of copper (I) uptake hindered the transcriptional activation of the subgroup Ib of basic helix-loop-helix (bHL…