Search results for "import"
showing 10 items of 286 documents
Whole genome sequencing-based analysis of tuberculosis (TB) in migrants: rapid tools for cross-border surveillance and to distinguish between recent …
2019
14 páginas, 7 figuras
The severe phenotype of Diamond-Blackfan anemia is modulated by heat shock protein 70.
2017
International audience; Diamond-Blackfan anemia (DBA) is a rare congenital bone marrow failure syndrome that exhibits an erythroid-specific phenotype. In at least 70% of cases, DBA is related to a haploinsufficient germ line mutation in a ribosomal protein (RP) gene. Additional cases have been associated with mutations in GATA1. We have previously established that the RPL11+/Mut phenotype is more severe than RPS19+/Mut phenotype because of delayed erythroid differentiation and increased apoptosis of RPL11+/Mut erythroid progenitors. The HSP70 protein is known to protect GATA1, the major erythroid transcription factor, from caspase-3 mediated cleavage during normal erythroid differentiation.…
Viral highway to nucleus exposed by image correlation analyses.
2018
AbstractParvoviral genome translocation from the plasma membrane into the nucleus is a coordinated multistep process mediated by capsid proteins. We used fast confocal microscopy line scan imaging combined with image correlation methods including auto-, pair- and cross-correlation, and number and brightness analysis, to study the parvovirus entry pathway at the single-particle level in living cells. Our results show that the endosome-associated movement of virus particles fluctuates from fast to slow. Fast transit of single cytoplasmic capsids to the nuclear envelope is followed by slow movement of capsids and fast diffusion of capsid fragments in the nucleoplasm. The unique combination of …
Protoparvovirus Knocking at the Nuclear Door
2017
Protoparvoviruses target the nucleus due to their dependence on the cellular reproduction machinery during the replication and expression of their single-stranded DNA genome. In recent years, our understanding of the multistep process of the capsid nuclear import has improved, and led to the discovery of unique viral nuclear entry strategies. Preceded by endosomal transport, endosomal escape and microtubule-mediated movement to the vicinity of the nuclear envelope, the protoparvoviruses interact with the nuclear pore complexes. The capsids are transported actively across the nuclear pore complexes using nuclear import receptors. The nuclear import is sometimes accompanied by structural chan…
Responsiveness and Minimal Clinically Important Difference of the Five Times Sit-to-Stand Test in Patients with Stroke
2021
This study aimed to analyze the responsiveness of the 5STS test among stroke patients and to estimate the MCIDs (minimal clinically important differences) for different severity levels of community ambulation and stages of recovery. The 5STS and comparator instruments (gait speed and Functional Ambulatory Category (FAC)) were evaluated at baseline. These measures were repeated at 4 (Stage 1) and 8 weeks (Stage 2), together with the Global Rating of Change (GROC). The MCIDs were calculated with two anchor-based methods using the GROC as the external criterion. Responsiveness to change for the 5STS was estimated analyzing the correlation with changes in the two comparator instruments and thei…
Statement complementing the EFSA Scientific Opinion on application (EFSA‐GMO‐DE‐2011‐95) for the placing on the market of genetically modified maize …
2018
Abstract The GMO Panel was previously not in the position to complete the food/feed safety assessment of maize 5307 due to an inadequate 28‐day toxicity study necessary for an appropriate assessment of eCry3.1Ab protein. Following a mandate from the European Commission, the GMO Panel assessed a supplementary 28‐day toxicity study in mice on the eCry3.1Ab protein (1,000 mg/kg body weight (bw) per day) to complement its scientific opinion on application EFSA‐GMO‐DE‐2011‐95 for the placing on the market of the maize 5307 for food and feed uses, import and processing. The supplementary 28‐day toxicity study did not show adverse effects. Taking into account the previous assessment and the new in…
Employers’ attitudes towards labour inclusion of persons with borderline intellectual functioning (BIF): An empirical evidence
2020
In the vocational rehabilitation of persons with disabilities (BIF), the need to consider the variables related to employer demand is increasingly becoming an important research topic. This empirical research explores the perceptions and attitudes of employers in hiring and retaining people with borderline intellectual functioning (BIF). For this purpose, the Metaplan procedure was used and a focus group was conducted in small and medium enterprises (SMEs) of the Spanish Vinalopó Footwear Cluster. Results showed a significant lack of knowledge and visibility of people with BIF. Lack of financial support to encourage hiring was pointed out by participants in the group as the most relevant ba…
Sexualitat en persones grans: Claus per entendre la satisfacció sexual i el seu vincle amb la salut sexual
2019
La satisfacció sexual s?ha convertit en una qüestió important dintre dels estudis sobre sexualitats, dels que sistemàticament les persones grans queden excloses al reduir la seua sexualitat a aspectes relacionats amb la mala salut. En aquest estudi s?analitza la satisfacció sexual amb la parella d?aquest grup de població a través de la Encuesta Nacional de Salud Sexual, prenent com a base el model biopsicosocial de la sexualitat (DeLamater, 2002) i considerant el gènere i diferents grups d?edat. Els resultats indiquen el caràcter multifactorial de la satisfacció sexual, prioritzant elements de natura relacional, social i cultural per sobre de l?estat de salut.
Neutralidad y honorabilidad del árbitro: : De la ética a la diligencia
2021
One of the main principles of arbitration is that the arbitral tribunal must be independent, impartial, neutral and diligent in carrying out its duties throughout the arbitration proceedings. However, the sophistication and complexity of arbitration as an extra-judicial dispute resolution procedure can undermine confidence in the efficiency of the system. In this regard, the professional (arbitral) ethics and the honourability of the arbitrator are of major importance. This article aims to highlight the importance of the neutrality of the arbitrator, the integrity of the arbitration and the reputation of this procedure
“El Registro Civil y el contenido de su publicidad: experiencias españolas para el contexto cubano”
2021
La función de publicidad que caracteriza al Registro Civil lo convierte en una institución fundamental dentro del sistema de seguridad jurídica preventiva. De ahí que, sea importante estudiar si existe correspondencia entre el contenido de la publicidad del Registro y las situaciones jurídicas y sociales en que usualmente se desenvuelven las personas, como un medio para garantizar, desde esta perspectiva, su cuidado y desarrollo. En este sentido, se valora el contenido de la publicidad del Registro del Estado Civil cubano (Ley No.51/1985, de 15 de julio del Registro del Estado Civil), a partir de las experiencias españolas en la materia, siguiendo, en general, los avances de este último sis…