Search results for "imprinting"
showing 4 items of 124 documents
Enantioselective Ester Hydrolysis Catalyzed by Imprinted Polymers. 2,
2000
Highly cross-linked network polymers prepared by molecular imprinting catalyzed enantioselectively the hydrolysis of N-tert-butoxycarbonyl phenylalanine-p-nitrophenyl ester (BOCPheONP). The templates were designed to allow incorporation of the key catalytic elements, found in the proteolytic enzyme chymotrypsin, into the polymer active sites. Three model systems were evaluated. These were constructed from a chiral phosphonate analogue of phenylalanine (series A, C) or L-phenylalanine (series B) attached by a labile ester linkage to an imidazole-containing vinyl monomer. Free radical copolymerization of the template with methacrylic acid (MAA) and ethylene glycol dimethacrylate (EDMA) gave a…
Genomic conflicts and sexual antagonism in human health: Insights from oxytocin and testosterone
2015
We review the hypothesized and observed effects of two of the major forms of genomic conflicts, genomic imprinting and sexual antagonism, on human health. We focus on phenotypes mediated by peptide and steroid hormones (especially oxytocin and testosterone) because such hormones centrally mediate patterns of physical and behavioral resource allocation that underlie both forms of conflict. In early development, a suite of imprinted genes modulates the human oxytocinergic system as predicted from theory, with paternally inherited gene expression associated with higher oxytocin production, and increased solicitation to mothers by infants. This system is predicted to impact health through the i…
Developments in the evolutionary theory of social interactions
2016
Altruistic behaviour, which benefits others but harms the actor, can evolve when copies of the underlying genes are transmitted to future generations by related beneficiaries. While we know that the mechanism of ‘kin selection’ answers to how altruism can evolve, the answers to why and when it can evolve are still obscure. The first aim of this thesis is to shed light to the evolution of altruism by identifying factors that facilitate or promote it. I find that the conditions under which altruism can evolve follow surprisingly simple principles that are independent of the taxon-specific traits such as fecundity. Further, by analysing the unique aspects of haplodiploid sex determination syst…
Early development of taste and flavor preferences and consequences on eating behavior
2018
The first 1000 days of life constitute an important period for development of health and eating behavior, in particular because the mode of feeding drastically evolves, which involves that the child has to learn “how” to eat, but also “what” to eat, “how” much food to eat. After birth, when foods are orally exposed, infants discover the intrinsic properties of foods, with a variety of tastes, flavors, textures, as well as energy densities. Here we focus on deciphering the involvement of taste and olfaction in the early establishment of eating behavior. In the OPALINE French birth cohort (Observatory of Food Preferences in Infants and Children), taste and flavor preferences were studied in c…