Search results for "imulation"

Chapter 31 Transcranial magnetic stimulation studies of contralesional space attention deficits

2002

Publisher Summary The power of transcranial magnetic stimulation (TMS) to disrupt and modulate the neural activity in focal brain regions has provided researchers in this field a promising tool to empirically test specific neuropsychological models and constructs of contralesional space attention deficits. A group of studies has used TMS to transiently disrupt the cortical activity of the focal brain areas in normal subjects to replicate the effects of neurological lesions. This chapter discusses a number of studies, using single-pulse, paired-TMS, and repetitive TMS (rTMS) and different experimental paradigms that show how this technique can be of fundamental importance, in elucidating the…

Multiphoton Absorption of Myoglobin Nitric-Oxide complex: Relaxation by D-NEMD of a Stationary State

2012

ABSTRACT: The photodissociation and geminate recombination of nitric oxide in myoglobin, under continuous illumination, is modeled computationally. The relaxation of the photon energy into the protein matrix is also considered in a single simulation scheme that mimics a complete experimental setup. The dynamic approach to non-equilibrium molecular dynamics is used, starting from a steady state, to compute its relaxation to equilibrium. Simulations are conducted for the native form of sperm whale myoglobin and for two other mutants, V68W and L29F, illustrating a fair diversity of spatial and temporal geminate recombination processes. Energy flow to the heme and immediate protein environment …

Water effects on trehalose matrices studied through Molecular Dynamics

2012

Computer Simulations of the Band Structure and Density of States of the Linear Chains of NaCl Ions

2019

The authors thank Eugene Kotomin and V. Kuzovkov for fruitful discussions and valuable suggestions. A.I.P thanks A.Moskina for the technical assistance in preparation of the manuscript. A.I.P also gratefully acknowledges a project LZP-2018/1-0214 from the Latvian Council of Science for partial support.

Identifying the Neurocognitive bases of creativity to increase human and computational creativity

2022

En esta Tesis Doctoral se ha identificado la estructura neurocognitiva que sustenta la creatividad humana a partir del análisis conjunto de más de 800 referencias bibliográficas que muestran las investigaciones más importantes realizadas hasta la fecha. Sobre la base de esta estructura, se ha identificado un paradigma neurocognitivo de la creatividad humana y se ha propuesto un modelo neurocognitivo del proceso creativo. Finalmente, también se ha propuesto un paradigma creativo neurocognitivo computacional y se ha diseñado la estructura de un sistema computacional creativo, basado en una estructura multiagente. La investigación que se ha realizado sobre el tema hasta la fecha es muy especia…

Transcranial Magnetic Stimulation and Neuroimaging Coregistration

2013

The development of neuroimaging techniques is one of the most impressive advancements in neuroscience. The main reason for the widespread use of these instruments lies in their capacity to provide an accurate description of neural activity during a cognitive process or during rest. This important advancement is related to the possibility to selectively detect changes of neuronal activity in space and time by means of different biological markers. Specifically, functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), and nearinfrared spectroscopy (NIRS) use metabolic markers of ongoing neuronal activity to provide a…

Thermodynamics and kinetics of ion translocation in the human wild-type and E-1_A α7 nicotinic receptor

2021

We use an all-atom model of the human nicotinic acetylcholine receptor α7 in a conductive conformation, to provide the first available mapping of the potential of mean force for the ion translocation across the channel. The modeling is based on MD simulations combined with the milestoning method with Voronoi tessellation. The quality of the protein model and description is confirmed by the agreement with experimental data for proteins of the same family. The specific mutation E-1 ' A at the cytoplasmatic filter is here shown to strongly affect both sodium and chloride permeation, leading to a complete inversion of selectivity.

Novel non-destructive inspection techniques for laser powder deposition inspection

2013

A novel non-destructive testing (NDT) techniques for inspection of parts and components manufactured by Additive Manufacturing Processes (AMP), in particular Laser Metal Deposition (LMD), has been developed. LMD is a technology that has been maturing over the last 20 years and has found application in repair, coatings, hybrid build and 3D near net shape manufacture of small intricate parts that can be used in aero and automobile engines to improve efficiency. Currently this technology cannot be used to supply some of these parts because absence of flaws, which might be left in the component during manufacture, cannot be guaranteed. Today, quality is assessed by sample destructive testing, w…

Brain Modulation by Electric Currents in Fibromyalgia: A Structured Review on Non-invasive Approach With Transcranial Electrical Stimulation

2018

Fibromyalgia syndrome (FMS) is a complex disorder where widespread musculoskeletal pain is associated with many heterogenous symptoms ranging from affective disturbances to cognitive dysfunction and central fatigue. FMS is currently underdiagnosed and often very poorly responsive to pharmacological treatment. Pathophysiology of the disease remains still obscure even if in the last years fine structural and functional cerebral abnormalities have been identified, principally by neurophysiological and imaging studies delineating disfunctions in pain perception, processing and control systems. On such basis, recently, neurostimulation of brain areas involved in mechanism of pain processing and …

Effects of tDCS on Bimanual Motor Skills: A Brief Review.

2018

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that allows the modulation of cortical excitability as well as neuroplastic reorganization using a weak constant current applied through the skull on the cerebral cortex. TDCS has been found to improve motor performance in general and motor learning in particular. However, these effects have been reported almost exclusively for unimanual motor tasks such as serial reaction time tasks, adaptation tasks, or visuo-motor tracking. Despite the importance of bimanual actions in most activities of daily living, only few studies have investigated the effects of tDCS on bimanual motor skills. The objectives …