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showing 10 items of 5395 documents
Hormone Replacement Therapy Associated White Blood Cell DNA Methylation and Gene Expression are Associated With Within-Pair Differences of Body Adipo…
2015
The loss of estrogen during menopause causes changes in the female body, with wide-ranging effects on health. Estrogen-containing hormone replacement therapy (HRT) leads to a relief of typical menopausal symptoms, benefits bone and muscle health, and is associated with tissue-specific gene expression profiles. As gene expression is controlled by epigenetic factors (including DNA methylation), many of which are environmentally sensitive, it is plausible that at least part of the HRT-associated gene expression is due to changes in DNA methylation profile. We investigated genome-wide DNA methylation and gene expression patterns of white blood cells (WBCs) and their associations with body compo…
Validity and Reliability of the Finnish Version of the Locomotor Capabilities Index-5 in Patients Fitted with a Prosthesis after Major Lower Extremit…
2019
EMAS position statement: Predictors of premature and early natural menopause.
2019
Simoncini, Tommaso/0000-0002-2971-0079; Chung, Hsin-Fang/0000-0003-3261-5942; Mishra, Gita/0000-0001-9610-5904 WOS:000468709100014 PubMed ID: 31027683 Introduction: While the associations of genetic, reproductive and environmental factors with the timing of natural menopause have been extensively investigated, few epidemiological studies have specifically examined their association with premature (< 40 years) or early natural menopause (40-45 years). Aim: The aim of this position statement is to provide evidence on the predictors of premature and early natural menopause, as well as recommendations for the management of premature and early menopause and future research. Materials and methods…
Is COVID‐19 infection more severe in kidney transplant recipients?
2021
International audience; There are no studies which have compared the risk of severe Covid-19 and related mortality between transplant recipients and non-transplant patients. We enrolled two groups of patients hospitalized for Covid-19, i.e., kidney transplant recipients from the French Registry of Solid Organ Transplant (n=306) and a single-center cohort of non-transplant patients (n=795). An analysis was performed among subgroups matched for age and risk factors for severe Covid-19 or mortality. Severe Covid-19 was defined as admission (or transfer) to an intensive care unit, need for mechanical ventilation, or death.Transplant recipients were younger and had more comorbidities compared to…
European guidelines on chronic mesenteric ischaemia - joint United European Gastroenterology, European Association for Gastroenterology, Endoscopy an…
2020
Chronic mesenteric ischaemia is a severe and incapacitating disease, causing complaints of post-prandial pain, fear of eating and weight loss. Even though chronic mesenteric ischaemia may progress to acute mesenteric ischaemia, chronic mesenteric ischaemia remains an underappreciated and undertreated disease entity. Probable explanations are the lack of knowledge and awareness among physicians and the lack of a gold standard diagnostic test. The underappreciation of this disease results in diagnostic delays, underdiagnosis and undertreating of patients with chronic mesenteric ischaemia, potentially resulting in fatal acute mesenteric ischaemia. This guideline provides a comprehensive overvi…
Anthropometric indices, lipid profile, and lipopolysaccharide-binding protein levels in metabolic endotoxemia: A case-control study in Calabar Metrop…
2020
Objectives: To determine the anthropometric indices, lipopolysaccharide-binding proteins (LBP), and lipid profile in patients with metabolic endotoxemia. Methods: The study comprised of 47 patients with metabolic endotoxemia (the metabolic endotoxemia group) and 43 controls (the control group). Patients in the metabolic endotoxemia group were categorized further into three subgroups including the normal weight group (n=8), the overweight group (n=12) and the obese group (n=27). Height, weight, waist, and hip circumference were measured, and waist-hip ratio (WHR) and body mass index (BMI) were calculated. LBP was determined by ELISA and total cholesterol, triglycerides, high density lipoprot…
Min-Type Control Strategy of a DC-DC Synchronous Boost Converter
2019
International audience; This paper presents the analysis and design of a min-type strategy to control a synchronous boost converter in continuous conduction mode. The strategy uses a nonlinear switching surface to establish the change of topology in the converter and is analyzed by means of a sliding-mode control approach. Subsequently, the min-type strategy is modified by a hybrid control formulation, which introduces a hysteresis width and a dwell-time to obtain a finite switching frequency in the start-up and steady-state respectively. The hybrid control formulation is implemented digitally by means of a microprocessor which processes the samples of inductor current and capacitor voltage…
Modelización de riesgos climáticos y sistemas de vigilancia y alerta en la Comunitat Valenciana
2013
El primer objetivo de esta Tesis está relacionado con el desarrollo e implementación de diferentes sistemas de vigilancia y alerta para el territorio de la Comunitat Valenciana: un sistema de predicción meteorológica en tiempo real basado en el modelo atmosférico de mesoescala Regional Atmospheric Modeling System (RAMS) y un sistema de previsión del Índice UV (UVI), basado en el modelo Santa Barbara DISORT Atmospheric Radiative Transfer (SBDART). Además, se propone una metodología que proporciona un entorno computacional adecuado para la administración y coordinación de los diferentes procesos implicados en ambos sistemas de vigilancia. La principal mejora de la predicción UVI es la utiliza…
Concentrations of metallothionein in the bivalve molluscsAnodonta spp.andUnio spp.from Latvian lakes with different anthropogenic pressure
2013
Concentrations of metallothioneins (MT) were analysed in bivalve molluscs Anodonta spp. and Unio spp. from 6 lakes and watercourses of Latvia with different anthropogenic pressure. The aim of the study was to find the relationship between MT in molluscs and concentrations of heavy metals in sediments. Unio spp. and Anodonta spp. showed no significant differences in the concentrations of MT. High concentrations of heavy metals (Cd, Pb, Hg, Cu, Zn) were detected in the deepest parts of polluted water bodies, however their concentrations significantly decreased in near shore sediments inhabited by molluscs. Only Zn tends to accumulate in the molluscs, reaching 2-7 times higher concentrations i…
MULTINATIONAL ENTERPRISES – DYNAMICS AND TRENDS
2012
Multinational enterprises (MNEs) represent both cause and result of the new economic geography of globalization. Thus, the dynamics and trends of the world’s most influential MNEs contribute decisively to the new global architecture and to the economic development, being influenced, at their turn, by these processes of continuous reconfiguration and evolution that take place on the global arena. The paper proposes a comparative (in space) and historical (in time) analysis of the most well known global rankings of the multinational enterprises – Fortune Global 500 on one hand, and The world's top 100 non-financial TNCs, ranked by foreign assets and Top 100 non-financial TNCs from developing …