Search results for "induced"
showing 10 items of 1287 documents
Metal Dependence on the Bidirectionality and Reversibility of the Singlet Energy Transfer in Artificial Special Pair-Containing Dyads
2017
International audience; The demetalation of a precursor dyad, 3, built upon a zinc(II)-containing artificial special pair and free-base antenna, leads to a new dyad, 4, for singlet energy transfer composed of cofacial free-base porphyrins (acceptor), [Fb](2) bridged by a 1,4-C6H4 group to a free-base antenna (donor), [Fb]. This dyad exhibits the general structure [M](2)-C6H4-[Fb], where [M](2) = [Fh](2), and completes a series reported earlier, where [M](2) = [Mg](2) (2) and [Zn](2) (3). The latter dyads exhibit a bidirectional energy-transfer process at 298 K for 2 and at 77 K for 3. Interestingly, a very scarce case of cycling process is observed for the zinc-containing dyad at 298 K. The…
Cognitive Impairment in Multiple Sclerosis Is Reflected by Increased Susceptibility to the Sound-Induced Flash Illusion
2019
Objective: To determine whether the performance of multiple sclerosis (MS) patients in the sound-induced flash illusion (SiFi), a multisensory perceptual illusion, would reflect their cognitive impairment.Methods: We performed the SiFi task as well as an extensive neuropsychological testing in 95 subjects [39 patients with relapse-remitting MS (RRMS), 16 subjects with progressive multiple sclerosis (PMS) and 40 healthy control subjects (HC)].Results: MS patients reported more frequently the multisensory SiFi than HC. In contrast, there were no group differences in the control conditions. Essentially, patients with progressive type of MS continued to perceive the illusion at stimulus onset a…
Pluripotent stem cells to model Hutchinson-Gilford progeria syndrome (HGPS): Current trends and future perspectives for drug discovery
2015
Progeria, or Hutchinson-Gilford progeria syndrome (HGPS), is a rare, fatal genetic disease characterized by an appearance of accelerated aging in children. This syndrome is typically caused by mutations in codon 608 (p.G608G) of the LMNA, leading to the production of a mutated form of lamin A precursor called progerin. In HGPS, progerin accumulates in cells causing progressive molecular defects, including nuclear shape abnormalities, chromatin disorganization, damage to DNA and delays in cell proliferation. Here we report how, over the past five years, pluripotent stem cells have provided new insights into the study of HGPS and opened new original therapeutic perspectives to treat the disea…
Pełna trójnaczyniowa rewaskularyzacja wieńcowa z użyciem ultra niskich dawek kontrastu jako strategia zachowania rezydualnej funkcji nerek u chorego …
2018
Nefropatia indukowana kontrastem jest poważnym powikłaniem koronarografii i przezskórnych interwencji wieńcowych (PCI) u chorych z przewlekłymi schorzeniami nerek. Jedyną realną strategią zapobiegawczą przed jej rozwojem jest adekwatne nawodnienie wraz z ograniczeniem objętości stosowanego kontrastu. Ostatnio zaproponowano nowe techniki diagnostyczne i terapeutyczne polegające na stosowaniu ultra niskich dawek kontrastu, co więcej opisano zabiegi PCI bez użycia kontrastu. W niniejszym artykule prezentujemy przypadek dializowanego chorego z ostrym zespołem wieńcowym i ciężką niewydolnością jedynej nerki, ale z zachowaną rezydualną jej funkcją, u którego przeprowadzono diagnostykę i pełną tró…
On the synthesis of functionalized porphyrins and porphyrin conjugates via β-aminoporphyrins
2016
International audience; The synthesis of functionalized porphyrins and their conjugates from meso-tetraarylporphyrins through the acylation and the oxidation of beta-aminoporphyrins was investigated. 2,3-Dioxochlorins were prepared by the oxidation of a variety of beta-aminoporphyrins and subsequently used in a condensation reaction with functionalized aromatic aldehydes and ammonium acetate to form beta-functionalized porphyrins bearing a fused imidazole ring. Under optimized experimental conditions both reactions tolerate various functional groups and afford the products in an appropriate overall yield. The mildness and usefulness of this methodology are illustrated by several examples in…
The Spike Noise Based on the Renewal Point Process and Its Possible Applications
2010
We consider a non-Markovian random process in the form of spikes train, where the time intervals between neighboring delta-pulses are mutually independent and identically distributed, i.e. represent the renewal process (1967). This noise can be interpreted as the derivative of well-known continuous time random walk (CTRW) model process with fixed value of jumps. The closed set of equations for the characteristic functional of the noise, useful to split the correlations between stochastic functionals (2008), is obtained. In the particular case of Poisson statistics these equations can be exactly solved and the expression for the characteristic functional coincides with the result for shot no…
Tulka profesijas riski
2017
Šis maģistra darbs pēta riskus ar kuriem tulki saskaras darba laikā. Darba mērķis ir noskaidrot vai risks tulku dzīvībai un veselībai pastāv ne tikai ekstrēmos apstākļos, piemēram, kara laikā, bet arī miera apstākļos. Tika veikta ne tikai ar šo tēmu saistīto zinātnisko darbu, mēdiju rakstu un blogu analīze, bet arī aptauja, lai noskaidrotu riska faktorus ar kuriem saskarās Latvijā strādājošie tulki. Izpēte atklāja, ka kara tulki ir pakļauti pat nopietnākiem un daudzveidīgākiem riskiem, nekā domāts; turklāt tika noskaidrots, ka tulka veselībai (gan garīgajai, gan fiziskajai) un pat dzīvībai pastāv draudi arī miera apstākļos – aizstājošā trauma un verbāla pazemošana ir īpaši izplatītas; diemž…
A Low Dose of Pure Cannabidiol Is Sufficient to Stimulate the Cytotoxic Function of CIK Cells without Exerting the Downstream Mediators in Pancreatic…
2022
Despite numerous studies conducted over the past decade, the exact role of the cannabinoid system in cancer development remains unclear. Though research has focused on two cannabinoid receptors (CB1, CB2) activated by most cannabinoids, CB2 holds greater attention due to its expression in cells of the immune system. In particular, cytokine-induced killer cells (CIKs), which are pivotal cytotoxic immunological effector cells, express a high-level of CB2 receptors. Herein, we sought to investigate whether inducing CIK cells with cannabidiol can enhance their cytotoxicity and if there are any possible counter effects in its downstream cascade of phosphorylated p38 and CREB using a pancreatic d…
Targeting DNA double strand break repair with hyperthermia and DNA-PKcs inhibition to enhance the effect of radiation treatment
2016
// Bregje van Oorschot 1 , Giovanna Granata 1 , Simone Di Franco 2 , Rosemarie ten Cate 1 , Hans M. Rodermond 1 , Matilde Todaro 3 , Jan Paul Medema 1 , Nicolaas A.P. Franken 1 1 Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine, Department of Radiation Oncology, Academic Medical Center, Cancer Genomics Center, Amsterdam, The Netherlands 2 Department of Surgical, Oncological and Stomatological Sciences (DICHIRONS), Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy 3 Biomedical Department of Internal and Specialistic Medicine (DIBIMIS), University of Palermo, Palermo, Italy Correspondence to: Nicol…
Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen
2022
Drug-induced liver injury (DILI) development is commonly associated with acetaminophen (APAP) overdose, where glutathione scavenging leads to mitochondrial dysfunction and hepatocyte death. DILI is a severe disorder without effective late-stage treatment, since N-acetyl cysteine must be administered 8 h after overdose to be efficient. Ammonia homeostasis is altered during liver diseases and, during DILI, it is accompanied by decreased glycine N-methyltransferase (GNMT) expression and S-adenosylmethionine (AdoMet) levels that suggest a reduced methionine cycle. Anti-miR-873-5p treatment prevents cell death in primary hepatocytes and the appearance of necrotic areas in liver from APAP-adminis…