Search results for "inflammation"

Corrigendum to “Inflammation and frailty in the elderly: A systematic review and meta-analysis” (Ageing Research Reviews (2016) 31 (1–18) (S156816371…

2017

Since the publication of our meta-analysis it has come to light that we inadvertently categorised one study (Gale et al. 2013) as a cross sectional study instead of its true design as a longitudinal study. We have recalculated the analyses affected which is isolated to the cross sectional longitudinal biomarkers of C reactive protein. The updated analyses have not significantly changed our findings regarding CRP or the narrative of the paper in any perceptible way. Specifically, the new OR for CRP longitudinal studies is now 1.08 (95%CI 0.87–1.34) compared to a previous value of 1.06 (95%CI: 0.78–1.44) (please see the new Fig. 1a). Similarly, after removing the study of Gale et al., the cro…

Role of MSCT scan in management of patients with primary epiploic appendagitis; our experience

2013

Purpose Methods and Materials Results Conclusion References Personal Information

Identifying the patient subset with highest inflammation levels in acute coronary syndromes

2019

The regulation of efferocytosis signaling pathways and adipose tissue homeostasis in physiological conditions and obesity: Current understanding and …

2022

Obesity is associated with changes in the resolution of acute inflammation that contribute to the clinical complications. The exact mechanisms underlying unresolved inflammation in obesity are not fully understood. Adipocyte death leads to pro-inflammatory adipose tissue macrophages, stimulating additional adipocyte apoptosis. Thus, a complex and tightly regulated process to inhibit inflammation and maintain homeostasis after adipocyte apoptosis is needed to maintain health. In normal condition, a specialized phagocytic process (efferocytosis) performs this function, clearing necrotic and apoptotic cells (ACs) and controlling inflammation. For efficient and continued efferocytosis, phagocyt…

Oxidative Stress, Chronic Inflammation, and Amyloidoses

2019

Hsp10: Anatomic distribution, functions, and involvement in human disease

2013

There is growing evidence that molecular chaperones/heat shock proteins are involved in the pathogenesis of a number of human diseases, known as chaperonopathies. A better molecular understanding of the pathogenetic mechanisms is essential for addressing new strategies in diagnostics, therapeutics and clinical management of chaperonopathies, including those in which Hsp10 is involved. This chaperonin has been studied for a long time as a member of the mitochondrial protein-folding machine. However, although in normal cells Hsp10 is mainly localized in the mitochondrial matrix, it has also been found during and after stress in other subcellular compartments, such as cytosol, vesicles and sec…

What is the physiological function of mast cells?

2003

Under physiological conditions, skin mast cells preferentially localize around nerves, blood vessels and hair follicles. This observation, which dates back to Paul Ehrlich, intuitively suggests that these enigmatic, multifacetted protagonists of natural immunity are functionally relevant to many more aspects of tissue physiology than just to the generation of inflammatory and vasodilatory responses to IgE-dependent environmental antigens. And yet, for decades, mainstream-mast cell research has been dominated by a focus on the -undisputedly prominent and important - mast cell functions in type I immune responses and in the pathogenesis and management of allergic diseases. Certainly, it is ha…

Anti–Inflammatory Activity in Human Skin: It Prevents Edema Formation in vitro

1999

Action of low doses of Aspirin in Inflammation and Oxidative Stress induced by aβ

2019

Aspirin has been used as anti-inflammatory and anti-aggregate for decades but the precise mechanism(s) of action after the presence of the toxic peptide Aβ1-42 in cultured astrocytes remains poorly resolved. Here we use low-doses of aspirin (10-7 M) in astrocytes in primary culture in presence or absence of Aβ1-42 toxic peptide. We noted an increase of cell viability and proliferation with or without Aβ1-42 peptide presence in aspirin treated cells. In addition, a decrease in apoptosis, determined by Caspase 3 activity and the expression of Cyt c and Smac/Diablo, were detected. Also, aspirin diminished necrosis process (LDH levels), pro-inflammatory mediators (IL-β and TNF-α) and NF-ᴋB prot…

Effect anti inflammatory and anti obesity of the polyphenolic extracts of carob leaves "Ceratonia siliqua" and cladode "Opuntia ficus-indica"

2018

In the present study, we have investigated the effects of polyphenol-rich infusions from carob leaves and OFI-cladodes on inflammation associated with obesity and dextran sulfate sodium (DSS)-induced ulcerative colitis in Swiss mice. In vitro studies revealed that aqueous extracts of carob leaves and OFI-cladodes exhibited anti-inflammatory properties marked by the inhibition of , TNF-α and nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells concomitant with NF-κβ nucleus translocation inhibition. For in vivo investigations, Swiss male mice were subjected to control or high fat diet (HFD). At the 4th week after the start of study, animals received or not 1% i…