Search results for "inflammatory"

Adrb3 adrenergic receptor is a key regulator of human myometrial apoptosis and inflammation during chorioamnionitis1

2008

The pathophysiology underlying preterm labor triggered by inflammatory conditions such as chorioamnionitis remains largely unclear. It has already been suggested that beta-3 adrenergic (ADRB3) agonists might be of interest in the pharmacological management of preterm labor. Although there is evidence implicating ADRB receptors in the control of inflammation, there are minimal data relating specifically to ADRB3. To explore the cellular consequences of chorioamnionitis and detect apoptosis, we first performed immunostaining and Western blot experiments on human myometrial samples obtained from women with confirmed chorioamnionitis. We then developed an in vitro model of chorioamnionitis by i…

Periodontitis and alzheimer´s disease

2020

Background Alzheimer's disease (AD), the main cause of dementia in the adult population, is characterized by a progressive loss of cognitive function. It is considered that neuroinflammation plays a fundamental role in its onset and progression. The bacteria present in the disbiotic microbiome generated during the course of periodontitis (PE) are capable of inducing a systemic inflammatory response, exacerbating the production of proinflammatory mediators that have the potential to spread to the systemic circulation. Material and Methods A literature review was made using the databases Scielo, PubMed, EBSCO and key words "Alzheimer disease", "Periodontitis", "Neurodegeneration", "Inflammati…

Acute impact of exercise on pro-onflammatory molecule concentrations in blood : factors that affect exercise induce response

2013

Pētījuma mērķis bija izpētīt slodzes intensitātes un ilguma, kā arī fiziskās sagatavotības līmeņa un imobilizācijas ietekmi uz citokīnu un citu slodzes izraisītu signālvielu koncentrācijām asinīs. Kopumā 98 jauni, veseli un fiziski aktīvi vīrieši piedalījās 4 dažādos fiziskās slodzes testos. Asins paraugi citokīnu un citu signālvielu noteikšanai tika ņemti pirms, pēc, kā arī slodzes laikā. Rezultāti liecina, ka akūta fiziskā slodze izraisa iekaisuma molekulu koncentrācijas pieaugumu asinīs. Pieaugot slodzes ilgumam un intensitātei, šī organisma atbildes reakcija pastiprinās, savukārt augstāks fiziskās sagatavotības līmenis šo reakciju samazina. Atkarībā no fiziskās slodzes veida, intensitāt…

Isolement et caractérisation de saponosides extraits de deux plantes médicinales : Cyclamen africanum, Zygophyllum cornutum et évalution de leur acti…

2014

The appearance of several diseases, such as cancer, diabetes, high blood pressure and spread of infections mutagenic virus type can be linked to the quality and lifestyle that we lead today. Indeed, several studies on the factors triggering these so-called "morbid" long-or short-term illnesses are related to stress and quality of food consumed, whether of plant and animal origin. These diseases are becoming a common occurrence, they affect different races and all classes of society. According ethnobotanical research, naturally occurring substances, allowed civilizations to survive deadly diseases. For example, we thus find references to periods of malarial fever in China and one of the symp…

Personality Traits, Defense Mechanisms and Perception of Quality of Life (QOL) in Patients With Inflammatory Bowel Disease (IBD) and Matched Controls

2012

Phenolic Profiles, Antioxidant and Anti-Inflammatory Activities of Hydrodistillation Wastewaters from Five Lamiaceae Species

2022

Distillation is the most widely used method to obtain an essential oil from plant material. The biomass used in the process is returned as a solid residue together with variable amounts of water rich in water-soluble compounds, which currently are not addressed to any further application. The scope of this work was to evaluate the phytochemical composition of wastewaters coming from hydrodistillation (DWWs) of five aromatic plants belonging to the Lamiaceae family, and to assess their in vitro antioxidant and anti-inflammatory activities. The phenolic profiles of the DWWs were determined by HPLC-DAD and HPLC-ESI/MS. Free radical scavenging ability, oxygen radical antioxidant capacity and su…

Gingivīta novērtēšana, izmantojot attālinātu fotopletismogrāfiju

2020

Pētījuma mērķis ir novērtēt smaganu perfūziju izmeklējamām personām izmantojot photopletizmogrāfijas metodi. Viens no pētījuma mērķiem bija reģistrēt kapsacīna izraisīto neiro-iekaisuma efektu. Metodoloģija Šķērsgriezuma pētījums, tika veikts iekļaujot nelielu izmeklējamo personu grupu , izmeklējamās personas pirms pētījuma veikšanas tika iepazīstinātas ar protokolu un rakstiski apstiprināja dalību pētījumā. Pētījuma gaitā smaganu perfūzijas tika reģistrēta miera apstākļos, un aplicējot uz smaganu virsmas kapsacīnu saturošu piparu ekstraktu, kas izraisīja pārejošu neirogēnu iekaisumu, ar tam raksturīgo hiperēmiju. Signāla reģistrācija tika veikta novietojot uz galvas izmeklējamai personai f…

Is Saffron Able to Prevent the Dysregulation of Retinal Cytokines Induced by Ocular Hypertension in Mice?

2021

Cytokine- and chemokine-mediated signalling is involved in the neuroinflammatory process that leads to retinal ganglion cell (RGC) damage in glaucoma. Substances with anti-inflammatory properties could decrease these cytokines and chemokines and thus prevent RGC death. The authors of this study analysed the anti-inflammatory effect of a hydrophilic saffron extract standardized to 3% crocin content, focusing on the regulation of cytokine and chemokine production, in a mouse model of unilateral laser-induced ocular hypertension (OHT). We demonstrated that following saffron treatment, most of the concentration of proinflammatory cytokines (IL-1β, IFN-γ, TNF-α, and IL-17), anti-inflammatory cyt…

Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis

2019

Objective: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that mainly targets joints. Monocytes and macrophages are critical in RA pathogenesis and contribute to inflammatory lesions. These extremely plastic cells respond to extracellular signals which cause epigenomic changes that define their pathogenic phenotype. Here, we interrogated how DNA methylation alterations in RA monocytes are determined by extracellular signals. Methods: High-throughput DNA methylation analyses of patients with RA and controls and in vitro cytokine stimulation were used to investigate the underlying mechanisms behind DNA methylation alterations in RA as well as their relationship with clinic…

Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders.

2021

The past decades have yielded major therapeutic advances in many autoimmune conditions – such as multiple sclerosis (MS) – and thus ushered in a new era of more targeted and increasingly potent immunotherapies. Yet this growing arsenal of therapeutic immune interventions has also rendered therapy much more challenging for the attending physician, especially when treating patients with more than one autoimmune condition. Importantly, some therapeutic strategies are either approved for several autoimmune disorders or may be repurposed for other conditions, therefore opening new curative possibilities in related fields. In this article, we especially focus on frequent and therapeutically rele…