Search results for "informatics"
showing 10 items of 2542 documents
The I3-CRB project and the French biological ressources centers
2010
International audience
Etudes d'objets combinatoires : applications à la bio-informatique
2011
This thesis considers classes of combinatorial objects that model data in bioinformatics. We have studied two methods of mutation of genes within the genome : duplication and inversion. At first,we study the problem of the whole mirror duplication-random lossmodel in terms of pattern avoiding permutations. We prove that the class of permutations obtained with this method after p duplications from the identity is the class of permutations avoiding alternating permutations of length 2p + 1.We also enumerate the number of duplications that are necessary and sufficient to obtain any permutation of length n from the identity. We also suggest two efficient algorithms to reconstruct two different …
Prise en compte de la technologie dans la quantification des biomarqueurs
2016
International audience; Part de la variance technologique dans la quantification des biomarqueurs. Exemple en protéomique avec la technologie MALDI-TOF
Protein S-nitrosylation: specificity and identification strategies in plants
2015
SPE Pôle IPM UB; International audience; The role of nitric oxide (NO) as a major regulator of plant physiological functions has become increasingly evident. To further improve our understanding of its role, within the last few years plant biologists have begun to embrace the exciting opportunity of investigating protein S-nitrosylation, a major reversible NO-dependent post-translational modification (PTM) targeting specific Cys residues and widely studied in animals. Thanks to the development of dedicated proteomic approaches, in particular the use of the biotin switch technique (BST) combined with mass spectrometry, hundreds of plant protein candidates for S-nitrosylation have been identi…
Public employees in South-Western Norway using an e-bike or a regular bike for commuting – A cross-sectional comparison on sociodemographic factors, …
2019
Large-scale analyses on the travel behavior of e-bikes are scarce, and current knowledge regarding who the e-bike owners are is inconsistent. Also, commuters represent a relevant user group with an unexploited potential. Therefore, the purpose of the present study was to examine (i) associations between type of bike (e-bike vs. regular bike) with place of residence (county), sociodemographic variables (age, sex, educational level, income and ethnicity) and habitual physical activity level, and (ii) if public employees possessing an e-bike cycle more often and longer distances to work. A cross-sectional survey was conducted in 2017 among 1977 (5.2% of eligible subjects) public employees in S…
A holistic perspective on the theoretical foundations for ICT4D research
2018
While many theories have guided research Information and Communication Technologies for Development (ICT4D), we are yet to construct a clear and coherent narrative that would help us answer the question of how ICT fosters development in underdeveloped communities. In this paper, we argue that one of the main reasons for this is that our holistic understanding of ICT4D is seldom grounded in theories to understand the core areas that define the field, namely, ICT, Development, and, ‘4’ which are the transformative processes that link the two. Through a brief literature review, we list theories that have informed ICT4D research in each of these areas. We present examples of theories, namely, C…
Oxidative Stress in COPD.
2019
Numerous studies over the years have shown that oxidative stress plays a major role in the development of the disease. Oxidative stress involvement in COPD opens up the possibility of using antioxidant therapies in the treatment of the disease. However, so far, these therapies have shown no clinical benefit indicating that more basic research efforts are needed to understand the underlying mechanisms by which oxidative stress leads to the development of COPD.
Distinctive amino acid residue periodicities in terminal sequences of type III and type I secreted proteins from proteobacteria
2007
AbstractThe Fourier transform (FT) method was applied to specify the distribution of 14 predefined groups of amino acids (64 residues) at both termini of annotated type III and type I secreted proteins from proteobacteria. Type I proteins displayed a higher occurrence of significant periodicities at both C-and N-termini, indicating potent features to discriminate between secretion types, particularly by the use of variables selected from the full periodicity profiles at 19 orders of FT. The Fishers linear discriminant analysis, together with the stepwise selection of variables throughout equal pairs of combinations for all predefined groups of residues, revealed the C-terminal harmonics of …
Hsp60, a Novel Target for Antitumor Therapy: Structure-Function Features and Prospective Drugs Design
2013
Heat shock protein 60 kDa (Hsp60) is a chaperone classically believed to be involved in assisting the correct folding of other mitochondrial proteins. Hsp60 also plays a role in cytoprotection against cell stressors, displaying for example, antiapoptotic potential. Despite the plethora of studies devoted to the mechanism of Hsp60's function, especially in prokaryotes, fundamental issues still remain unexplored, including the definition of its role in cancer. Key questions still unanswered pertain to the differences in structure-function features that might exist between the well-studied prokaryotic GroEL and the largely unexplored eukaryotic Hsp60 proteins. In this article we discuss these …
A novel pilot study of automatic identification of EMF radiation effect on brain using computer vision and machine learning
2020
Abstract Electromagnetic field (EMF) radiations from mobile phones and cell tower affect brain of humans and other organisms in many ways. Exposure to EMF could lead to neurological changes causing morphological or chemical changes in the brain and other internal organs. Cellular level analysis to measure and identify the effect of mobile radiations is an expensive and long process as it requires preparing the cell suspension for the analysis. This paper presents a novel pilot study to identify changes in brain morphology under EMF exposure considering drosophila melanogaster as a specimen. The brain is automatically segmented, obtaining microscopic images from which discriminatory geometri…