Search results for "informatics"

A Dataset of Annotated Omnidirectional Videos for Distancing Applications

2021

Omnidirectional (or 360°) cameras are acquisition devices that, in the next few years, could have a big impact on video surveillance applications, research, and industry, as they can record a spherical view of a whole environment from every perspective. This paper presents two new contributions to the research community: the CVIP360 dataset, an annotated dataset of 360° videos for distancing applications, and a new method to estimate the distances of objects in a scene from a single 360° image. The CVIP360 dataset includes 16 videos acquired outdoors and indoors, annotated by adding information about the pedestrians in the scene (bounding boxes) and the distances to the camera of some point…

CoproID predicts the source of coprolites and paleofeces using microbiome composition and host DNA content

2020

Shotgun metagenomics applied to archaeological feces (paleofeces) can bring new insights into the composition and functions of human and animal gut microbiota from the past. However, paleofeces often undergo physical distortions in archaeological sediments, making their source species difficult to identify on the basis of fecal morphology or microscopic features alone. Here we present a reproducible and scalable pipeline using both host and microbial DNA to infer the host source of fecal material. We apply this pipeline to newly sequenced archaeological specimens and show that we are able to distinguish morphologically similar human and canine paleofeces, as well as non-fecal sediments, fro…

Design and rationale of a nationwide screening analysis from the LIPIDOGRAM2015 and LIPIDOGEN2015 studies.

2022

IntroductionCardiovascular disease (CVD) is a major cause of morbidity and mortality throughout the world. The LIPIDOGRAM2015 study was performed to estimate the prevalence of risk factors for atherosclerotic diseases as well as cardiovascular and related disorders in the primary care setting in Poland. The LIPIDOGEN2015 sub-study was designed to include a random cohort of patients in order to analyse parameters related to lipid metabolism, oxidative stress, inflammatory responses, autoimmune disorders, and gene variants that confer susceptibility to cardiometabolic and atherosclerotic diseases.Material and methodsThe recruitment was carried out by 438 primary care physicians in Poland. The…

(R)-(−)-Quinuclidin-3-ol

2013

The structure of the title compound [alternatively called (R)-(−)-1-azabicyclo[2.2.2]octan-3-ol], C7H13NO, at 100 K has hexagonal (P61) symmetry. The structure shows a twist along the C—N pseudo-threefold axis. In the crystal, molecules are linkedviaO—H...N hydrogen bonds, forming infinite chains along thec-axis direction. The crystal studied was twinned by merohedry (twin law: 010, 100, 00-1; population: 0.925:0.075)

Set Membership (In) Validation of nonlinear positive models for biological systems

2006

The complexity of biology needs quantitative tools in order to support and validate biologists intuition and traditional qualitative descriptions. In this paper, Nonlinear Positive models with constraints for biological systems are validated/invalidated in a worst-case deterministic setting. These models are usefull for the analysis of the DNA and RNA evolution and for the description of the population dynamics of viruses and bacteria. The conditional central estimate and the Uncertainty Intervals are determined in order to validate/invalidate the model. The effectiveness of the proposed procedure has been illustrated by means of simulation experiments.

Biosilica-Based Strategies for Treatment of Osteoporosis and Other Bone Diseases

2011

Osteoporosis is a common disease in later life, which has become a growing public health problem. This degenerative bone disease primarily affects postmenopausal women, but also men may suffer from reduced bone mineral density. The development of prophylactic treatments and medications of osteoporosis has become an urgent issue due to the increasing proportion of the elderly in the population. Apart from medical/hormonal treatments, current strategies for prophylaxis of osteoporosis are primarily based on calcium supplementation as a main constituent of bone hydroxyapatite mineral. Despite previous reports suggesting an essential role in skeletal growth and development, the significance of …

Current understanding of genetic polymorphisms as biomarkers for risk of biological complications in implantology

2018

Background In the last decade, multiple studies have been published that analyze the relationship between the risk of experiencing biological complications with implants and the presence of certain types of genetic polymorphisms. In the present report, we analyze the controversies that have arisen from this important area of investigation and synthesize the most prominent aspects of knowledge related to this possible etiopathogenic relationship. Material and methods For this review, the biomedical databases PubMed-Medline, SciELO, and DOAJ were used. Different search strategies were employed, from which 298 articles initially emerged. After refinement of the search, 55 articles published be…

Identification of Replicator Mutator models

2006

The complexity of biology literally calls for quantitative tools in order to support and validate biologists intuition and traditional qualitative descriptions. In this paper, the Replicator-Mutator models for Evolutionary Dynamics are validated/invalidated in a worst-case deterministic setting. These models analyze the DNA and RNA evolution or describe the population dynamics of viruses and bacteria. We identify the Fitness and the Replication Probability parameters of a genetic sequences, subject to a set of stringent constraints to have physical meaning and to guarantee positiveness. The conditional central estimate is determined in order to validate/invalidate the model. The effectivene…

Oxidative stress, endothelial biomarkers and non-invasive vascular function in the general population in health and disease

2013

Capacity building in clinical and molecular characterization of rare neurodegenerative diseases through the development of a local register and impro…

2020

Neurodegenerative diseases (NDs) are very polymorphic and affect people of all ages. They concern both rare diseases and more common diseases. Improving knowledge of NDs in the French Caribbean region requires special attention because of the unique environmental and genetic background of its populations. In Martinique, there is a huge need for scientific research on rare NDs. While epidemiological and clinical research has increased over the past decade in the French West Indies, there is still little or no data on the genetics of NDs in these regions. The advent of Next Generation Sequencing (NGS) on a global scale has the potential to make a difference in this field, provided that techno…