Search results for "informatics"
showing 10 items of 2542 documents
An improvement of ComiR algorithm for microRNA target prediction by exploiting coding region sequences of mRNAs
2020
AbstractMicroRNA are small non-coding RNAs that post-transcriptionally regulate the expression levels of messenger RNAs. MicroRNA regulation activity depends on the recognition of binding sites located on mRNA molecules. ComiR is a web tool realized to predict the targets of a set of microRNAs, starting from their expression profile. ComiR was trained with the information regarding binding sites in the 3’utr region, by using a reliable dataset containing the targets of endogenously expressed microRNA in D. melanogaster S2 cells. This dataset was obtained by comparing the results from two different experimental approaches, i.e., inhibition, and immunoprecipitation of the AGO1 protein--a comp…
Clinical measurement of tooth wear: Tooth Wear Indices
2012
Attrition, erosion, and abrasion result in alterations to the tooth and manifest as tooth wear. Each classification corresponds to a different process with specific clinical features. Classifications made so far have no accurate prevalence data because the indexes do not necessarily measure a specific etiology, or because the study populations can be diverse in age and characteristics. Tooth wears (attrition, erosion and abrasion) is perceived internationally as a growing problem. However, the interpretation and comparison of clinical and epidemiological studies, it is increasingly difficult because of differences in terminology and the large number of indicators/indices that have been deve…
De Kelsen a la informática jurídica: una entrevista con Mario G. Losano
2018
Desde que su mentor, Norberto Bobbio, le encargara la traducción de la segunda edición de la Teoría pura del derecho (1960), la carrera de Mario G. Losano ha sido tan larga como polifacética. En esta entrevista, conversamos sobre su formación y sobre el contexto cultural que envolvió el inicio de su carrera académica en Italia. Posteriormente, nos centramos en dos de los principales temas de su producción académica. Por un lado, profundizamos en sus estudios kelsenianos, destacando el enfoque histórico que caracteriza su aproximación a los problemas iusfilosóficos. Y, por otro lado, abordamos el asunto de los orígenes y el desarrollo de la informática jurídica, de la cual el profesor Losano…
Accurate estimation of retinal vessel width using bagged decision trees and an extended multiresolution Hermite model.
2012
We present an algorithm estimating the width of retinal vessels in fundus camera images. The algorithm uses a novel parametric surface model of the cross-sectional intensities of vessels, and ensembles of bagged decision trees to estimate the local width from the parameters of the best-fit surface. We report comparative tests with REVIEW, currently the public database of reference for retinal width estimation, containing 16 images with 193 annotated vessel segments and 5066 profile points annotated manually by three independent experts. Comparative tests are reported also with our own set of 378 vessel widths selected sparsely in 38 images from the Tayside Scotland diabetic retinopathy scre…
SOLID LIPID NANOPARTICLES FOR APPLICATIONS IN GENE THERAPY: A REVIEW OF THE STATE OF THE ART
2010
Importance of the field. Gene therapy represents a new paradigm in the prevention and treatment of many inherited and acquired diseases, including genetic disorders, such as cystic fibrosis, haemophilia and many somatic diseases, such as tumours, neurodegenerative diseases and viral infections, such as AIDS. Areas covered in this review. Among a large array of non-viral transfection agents used for in-vitro applications, cationic SLNs are the topic of this review, being recently proposed as an alternative carrier for DNA delivery, due to many technological advantages such as large-scale production from substances generally recognized as safe, good storage stability and possibility of steam …
Active learning strategies for the deduplication of electronic patient data using classification trees.
2012
Graphical abstractDisplay Omitted Highlights? Active learning for medical record linkage is used on a large data set. ? We compare a simple active learning strategy with a more sophisticated variant. ? The active learning method of Sarawagi and Bhamidipaty (2002) 6] is extended. ? We deliver insights into the variations of the results due to random sampling in the active learning strategies. IntroductionSupervised record linkage methods often require a clerical review to gain informative training data. Active learning means to actively prompt the user to label data with special characteristics in order to minimise the review costs. We conducted an empirical evaluation to investigate whether…
Applying RUG-III for reimbursement of nursing facility care
2006
The Resource Utilization Groups (RUG-III) case-mix classification is becoming an internationally accepted methodology for determining payment for nursing facility and care. In this paper we discuss the key concepts of case-mix reimbursement and several different payment approaches based on RUG-III. In discussing the empirical evidence of case-mix reimbursement, we draw especially on the US experience. Clearly, the success of case-mix reimbursement depends not only on the payment design, but also on the ability to foresee market conditions and the regulatory environment in which the payment system is being implemented. Moreover, we demonstrate the need to develop a case-mix based reimburseme…
Adaptive scheduling of acceleration and gyroscope for motion artifact cancelation in photoplethysmography
2022
Background and objective: Recently, various algorithms have been introduced using wrist-worn photo-plethysmography (PPG) to provide high accuracy of instantaneous heart rate (HR) estimation, including during high-intensity exercise. Most studies focus on using acceleration and/or gyroscope signals for the motion artifact (MA) reference, which attenuates or cancels out noise from the MA-corrupted PPG signals. We aim to open and pave the path to find an appropriate MA reference selection for MA cancelation in PPG.Methods: We investigated how the acceleration and gyroscope reference signals correlate with the MAs of the distorted PPG signals and derived both mathematically and experimentally a…
Training Cognitive Functions Using Mobile Apps in Breast Cancer Patients: Systematic Review
2019
Background: Breast cancer is an invalidating disease and its treatment can bring serious side effects that have a physical and psychological impact. Specifically, cancer treatment generally has a strong impact on cognitive function. In recent years, new technologies and eHealth have had a growing influence on health care and innovative mobile apps can be useful tools to deliver cognitive exercise in the patient’s home. Objective: This systematic review gives an overview of the state-of-the-art mobile apps aimed at training cognitive functions to better understand whether these apps could be useful tools to counteract cognitive impairment in breast cancer patients. Methods: We searched in a …
Empowering Patients Living With Chronic Conditions Using Video as an Educational Tool: Scoping Review
2021
[EN] Background: Video is used daily for various purposes, such as leisure, culture, and even learning. Currently, video is a tool that is available to a large part of the population and is simple to use. This audio-visual format has many advantages such as its low cost, speed of dissemination, and possible interaction between users. For these reasons, it is a tool with high dissemination and educational potential, which could be used in the field of health for learning about and management of chronic diseases by adult patients. Objective: The following review determines whether the use of health educational videos by adult patients with chronic diseases is effective for their self-manageme…