Search results for "init"
showing 10 items of 6629 documents
Induction of regulatory T cells by leflunomide in a murine model of contact allergen sensitivity.
2006
Allergic contact dermatitis and contact hypersensitivity (CHS) are characterized by allergen-specific activation of CD8 + and CD4 + T cells and the production of cytokines resulting in an inflammatory response and tissue damage. We show here that the immunosuppressive compound leflunomide ( N -[4-trifluoro-methylphenyl]-5-methylisoxazol-4 carboxamide, HWA 486) (LF) inhibited the contact allergic response induced in mice by epicutaneous application of the haptens dinitrofluorobenzene (DNFB) and oxazolone. The extent of ear swelling remained significantly reduced following repeated challenge with DNFB for up to 18 weeks. LF and DNFB had to be applied simultaneously for inhibition to occur. Th…
NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells
2005
The phenotype of NFATc2(-/-) c3(-/-) (double knockout [DKO]) mice implies a disturbed regulation of T cell responses, evidenced by massive lymphadenopathy, splenomegaly, and autoaggressive phenomena. The population of CD4(+) CD25(+) T cells from DKO mice lacks regulatory capacity, except a small subpopulation that highly expresses glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR) and CD25. However, neither wild-type nor DKO CD4(+) CD25(+) regulatory T cells (T reg cells) are able to suppress proliferation of DKO CD4(+) CD25(-) T helper cells. Therefore, combined NFATc2/c3 deficiency is compatible with the development of CD4(+) CD25(+) T reg cells but renders c…
IL-28A Is a Key Regulator of T-Cell–Mediated Liver Injury via the T-Box Transcription Factor T-Bet
2006
Background & Aims: T-cell–mediated fulminant hepatitis is a potentially life-threatening event for which the underlying pathogenic mechanisms are not fully understood. Here, we demonstrate a key regulatory role of IL-28A in T-cell–mediated hepatitis. Methods: We cloned the murine IL-28A gene by reverse-transcription polymerase chain reaction, assessed the effects of recombinant IL-28A, and generated IL-28A–transgenic mice. Results: IL-28A induced TH1 cytokine production by CD4+ T lymphocytes in a T-bet–dependent manner and was up-regulated in a murine model of T-cell–mediated hepatitis upon Con A administration. In vivo, CD4+ T cells from newly created IL-28A–transgenic animals revealed an …
Tensile behaviour of anti-symmetric CFRP composite
2011
Abstract This paper addresses the response of a 17-ply anti-symmetric carbon/epoxy composite subjected to uniaxial tensile loading. Hashin ply damage model is adopted to describe the damage behaviour of the plies, whereas damage initiation and progression of the interfaces are characterised by mixed-mode cohesive damage model. Force-displacement curves obtained numerically and experimentally show good agreement. Results show that all laminae and interfaces experience the damage except laminae with 0o fibre. In addition, damage is concentrated at the tab and central regions of the tensile specimen. Edge delamination is observed in all interfaces.
Analytic response relativistic coupled-cluster theory: the first application to indium isotope shifts
2019
With increasing demand for accurate calculation of isotope shifts of atomic systems for fundamental and nuclear structure research, an analytic energy derivative approach is presented in the relativistic coupled-cluster theory framework to determine the atomic field shift and mass shift factors. This approach allows the determination of expectation values of atomic operators, overcoming fundamental problems that are present in existing atomic physics methods, i.e. it satisfies the Hellmann-Feynman theorem, does not involve any non-terminating series, and is free from choice of any perturbative parameter. As a proof of concept, the developed analytic response relativistic coupled-cluster the…
Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel
2015
Statins are one of the most commonly prescribed drugs in clinical practice. They are usually well tolerated and effectively prevent cardiovascular events. Most adverse effects associated with statin therapy are muscle-related. The recent statement of the European Atherosclerosis Society (EAS) has focused on statin-associated muscle symptoms (SAMS), and avoided the use of the term 'statin intolerance'. Although muscle syndromes are the most common adverse effects observed after statin therapy, excluding other side effects might underestimate the number of patients with statin intolerance, which might be observed in 10 - 15% of patients. In clinical practice, statin intolerance limits effecti…
The Affective Turn and Sacred Femininity in African American Women's Literature
2017
Després del llarg viatge a través de l’Atlàntic a bord dels vaixells esclavistes, els africans van veure’s obligats a enfrontar-se a la seua completa alienació física, social i també espiritual en les terres de l’anomenat ‘Nou Món’. La seua anterior concepció de l’univers com a un lloc on poden exisitir-hi un ventall il·limitat de déus es va veure estroncat per la imposició social d’un univers on l’esclau va perdre tant el seu sentit d’espai com de temps. Així doncs, la evolució històrica del poble afroamericà s’esmerça en conrear una concepció sagrada del seu entorn des del mateix moment en que arriben a terres americanes. Aquesta obligada gestació espiritual els commina a acollir i, alhor…
Spectral function for overoccupied gluodynamics from real-time lattice simulations
2018
We study the spectral properties of a highly occupied non-Abelian non-equilibrium plasma appearing ubiquitously in weak coupling descriptions of QCD matter. The spectral function of this far-from-equilibrium plasma is measured by employing linear response theory in classical-statistical real-time lattice Yang-Mills simulations. We establish the existence of transversely and longitudinally polarized quasiparticles and obtain their dispersion relations, effective mass, plasmon frequency, damping rate and further structures in the spectral and statistical functions. Our new method can be interpreted as a non-perturbative generalization of hard thermal loop (HTL) effective theory. We see indica…
Study of heavy meson production in p-Pb collisions at $\sqrt{S}$=5.02 TeV in the general-mass variable-flavour-number scheme
2017
Nuclear physics / B 925, 415 - 430 (2017). doi:10.1016/j.nuclphysb.2017.10.016
Stress Transfer within CNT Fibres: A FEA Approach
2015
Abstract Carbon nanotube (CNT) fibres are characterized by extreme anisotropy in their structure and physical properties. These fibres have been shown to have high axial strength, but poor shear strength between carbon nanotubes; for this reason it is difficult to transfer stress uniformly acrossthe fibre cross section. Here, Finite Element Analysis (FEA) is used to predict the stress distribution and the stress-strain curves of CNT fibres. The resultsdemonstrate that, in accordance with St. Venant principle,very considerable length-to-diameter ratios (> 10 3 ) are required to obtain a uniform stress distribution within the fibres even in the presence of low applied strain.