Search results for "inn"

2020

The transfer of metabolites through the mitochondrial membranes is a vital process that is highly controlled and regulated by the inner membrane. A variety of metabolites, nucleotides, and cofactors are transported across the inner mitochondrial membrane (IMM) by a superfamily of membrane transporters which are known as the mitochondrial carrier family (MCF) or the solute carrier family 25 (SLC25 protein family). In humans, the MCF has 53 members encoded by nuclear genes. Members of the SLC25 family of transporters, which is the largest group of solute carriers, are also known as mitochondrial carriers (MCs). Because MCs are nuclear-coded proteins, they must be imported into the IMM. When c…

2'-O-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recogn…

2019

Bacterial RNA has emerged as an important activator of innate immune responses by stimulating Toll-like receptors TLR7 and TLR8 in humans. Guanosine 2′-O-methylation at position 18 (Gm18) in bacterial tRNA was shown to antagonize tRNA-induced TLR7/8 activation, suggesting a potential role of Gm18 as an immune escape mechanism. This modification also occurs in eukaryotic tRNA, yet a physiological immune function remained to be tested. We therefore set out to investigate the immune modulatory role of Gm18 in both prokaryotic and eukaryotic microorganisms, Escherichia coli and Saccharomyces cerevisiae, and in human cells. Using RiboMethSeq analysis we show that mutation of trmH in E. coli, trm…

Innovative Green Technologies of Intensification for Valorization of Seafood and Their By-Products

2019

The activities linked to the fishing sector generate substantial quantities of by-products, which are often discarded or used as low-value ingredients in animal feed. However, these marine by-products are a prominent potential good source of bioactive compounds, with important functional properties that can be isolated or up-concentrated, giving them an added value in higher end markets, as for instance nutraceuticals and cosmetics. This valorization of fish by-products has been boosted by the increasing awareness of consumers regarding the relationship between diet and health, demanding new fish products with enhanced nutritional and functional properties. To obtain fish by-product-derived…

Altruistic leadership and affiliative humor's role on service innovation: Lessons from Spanish public hospitals.

2018

Despite literature identifies aspects that might promote innovation, the relationship between the leadership style and nurses' innovative behavior still remains unclear, and little research has provided evidence of this. To help advance in knowledge of effects of leadership on nurses' innovative behavior, we researched the effect of altruistic leadership on nurses' innovative behavior. In addition, the mediating role of affiliative humor in the relationship between altruistic leadership and nurses' innovative behavior was examined. Questionnaire survey method was followed with a sample of 324 nurses working in public hospitals in Spain. We used structural equation models, to check the resea…

Photovoice—Towards Engaging and Empowering People with Intellectual Disabilities in Innovation

2020

E-health and welfare technology offer new ways to support health and social care delivery. While initiatives are made to engage disadvantaged user groups in innovation, people with intellectual disabilities tend to be excluded from design activities. This is a concern as this group can benefit from the use of assistive technology. However, it can be time-consuming and challenging to involve end-users in the design of technology. This calls for processes that are creative, empowering and that facilitate user involvement. In this study, we report and reflect on the process of using photovoice to understand user needs and to empower participants with intellectual disability in an innovation pr…

Groupthink and Project Performance: The Influence of Personal Traits and Interpersonal Ties

2015

Contains fulltext : 166103.pdf (Publisher’s version ) (Closed access) This study explores whether the negative impact of “groupthink concurrence-seeking behavior” (GTB) on business process reengineering (BPR) projects is affected by group members personal traits and interpersonal ties within the group. To this purpose we conduct and present the results of a longitudinal controlled field experiment over 18 BPR projects lasting 3 months and involving 18 teams comprising 71 first-year MBA students. The main contribution of this study is twofold. First, we explicitly consider and measure the core construct of groupthink phenomenon: that is, GTB. Existing organizational behavior literature has, …

Innovative culture in district innovation systems of European ceramics SMEs

2017

We need to understand the dynamics of current local production systems in the form of industrial districts and, particularly, how culture and innovation are interlinked. In this paper, we argue that the district innovation system approach, which covers the innovation systems and industrial district literatures, provides a set of ideas useful for understanding the role of culture in innovation in industrial districts. We study the role of innovation culture in two of the most important European ceramics industrial districts in Italy and Spain. Specifically, we analyse how, within a given district system, the innovation culture, networks and social structure, and their inter-relations, influe…

Identifying and understanding spa tourists’ wellness attitudes

2018

As an increasing number of people in affluent societies are trending toward more health-conscious lifestyles, tourism consumer behavior has changed considerably, especially in the spa and wellness ...

Bariery rozwoju rodzinnych gospodarstw rolnych w opinii ich właścicieli z województwa opolskiego = Barriers to the development of family farms in the…

2018

Celem opracowania jest identyfikacja zmian w zachowaniach organizacyjnych i produkcyjnych właścicieli towarowych gospodarstw rolnych służących zapewnieniu trwałości gospodarstw oraz poznanie głównych barier, których przezwyciężenie jest istotne dla budowania potencjałów rozwojowych rolnictwa i obszarów wiejskich w województwie opolskim. W badaniach uwzględniono czynniki egzogeniczne i endogeniczne, w szczególności: politykę rolną, wielowarstwowe otoczenie instytucjonalne, gotowość rolników do inwestowania, zmiany w technologii produkcji, poszukiwanie nisz specjalizacyjnych. Źródłem informacji były badania ankietowe przeprowadzone wśród właścicieli gospodarstw, produkujących głównie na rynek…

Dynamic Functional Connectivity Captures Individuals’ Unique Brain Signatures

2020

Recent neuroimaging evidence suggest that there exists a unique individual-specific functional connectivity (FC) pattern consistent across tasks. The objective of our study is to utilize FC patterns to identify an individual using a supervised machine learning approach. To this end, we use two previously published data sets that comprises resting-state and task-based fMRI responses. We use static FC measures as input to a linear classifier to evaluate its performance. We additionally extend this analysis to capture dynamic FC using two approaches: the common sliding window approach and the more recent phase synchrony-based measure. We found that the classification models using dynamic FC pa…