Search results for "inn"
showing 10 items of 7124 documents
Echinoderm Antimicrobial Peptides: The Ancient Arms of the Deuterostome Innate Immune System
2016
Antimicrobial peptides (AMPs) are widely expressed in organisms and have been linked to innate and acquired immunity in vertebrates. These compounds are constitutively expressed from different cellular types to interact directly with infectious agents and/or modulate immunoreactions. In invertebrates, including echinoderms, which lack a vertebrate-type adaptive immune system, AMPs represent the major humoral defense system against infection, showing a diverse spectrum of action mechanisms, most of them related to plasma membrane disturbance and lethal alteration of microbial integrity. Here, we summarize the knowledge of AMPs in echinoderms as Strongylocins identified in the sea urchins, St…
Peritoneal Cavity is a Route for Gut-Derived Microbial Signals to Promote Autoimmunity in Non-Obese Diabetic Mice
2015
Macrophages play a crucial role in innate immune reactions, and peritoneal macrophages (PMs) guard the sterility of this compartment mainly against microbial threat from the gut. Type 1 diabetes (T1D) is an autoimmune disease in which gut microbiota and gut immune system appear to contribute to disease pathogenesis. We have recently reported elevated free radical production and increased permeability of gut epithelium in non-obese diabetic (NOD) mice. Impaired barrier function could lead to bacterial leakage to the peritoneal cavity. To explore the consequences of impaired gut barrier function on extra-intestinal immune regulation, we characterized peritoneal lavage cells from young newly w…
Role of the virulence plasmid pR99 and the metalloprotease Vvp in resistance of Vibrio vulnificus serovar E to eel innate immunity
2007
Vibrio vulnificus biotype 2 serovar E (VSE) is a bacterial pathogen that produces a haemorrhagic septicaemia called vibriosis in eels. Its ability to grow in blood is conferred by a recently described virulence plasmid [Lee CT, Amaro C, Wu KM, Valiente E, Chang YF, Tsai SF, et al. A common virulence plasmid in biotype 2 Vibrio vulnificus and its dissemination aided by a conjugal plasmid. Journal of Bacteriology, submitted for publication.]. In this study, we analyzed the role of this plasmid together with the role played by the metalloprotease (Vvp) in the interaction between bacteria and eel innate immunity. To this end, we compared and statistically analyzed the differences in resistance …
Use of electron spectroscopic imaging to determine element composition of the melanin granules in the stria vascularis of the guinea pig.
1998
Electron spectroscopic imaging (ESI) was used to analyze the element content of melanin granules in the stria vascularis seen in ultrathin sections of Spurr-embedded cochleae of the guinea pig. To determine element composition, ESI images were taken at different ionization edges, and non-specific background signals were subtracted digitally by an image processing system. The presence of calcium and nitrogen in the melanin granules could be demonstrated clearly. The calcium identified in the melanin granules was then compared with the spatial distributions of calcium binding sites after the application of an antimonate precipitation method, which was used to localize loosely bound calcium. D…
Dietary administration effects of exopolysaccharide from potential probiotic strains on immune and antioxidant status and nutritional value of Europe…
2020
The use of biological immunostimulants is considered a valuable practice to improve culture conditions in aquaculture sector that may help to increase production and maintain healthy environment. We undertook this study in order to evaluate the potential effect of the administration of two exopolysaccharides (EPS) "EPLB" and "EPB" derived from potential probiotic strains on immune and antioxidant status of European sea bass (Dicentrarchus labrax L.) larvae. In order to find out if the EPSs have an effect on the biochemical composition during the trial period, the nutritional value has been evaluated. The results revealed that expression levels of immune-relevant genes (infg, Il1b, Il8, Il6 …
Kultūrapmaiņas iespaids un “citādība” Vācijas pilsētu pirmajā koplīgumā starp Eizenhūtenštati un Zārluī no 1986 līdz šodienai
2018
Abstrakts: Šajā darbā izmantotā kvalitatīvā analīze apskata Vācijas pirmo veiksmīgi noslēgto starppilsētu sadraudzības līgumu starp Eisenhüttenstadt un Saarlouis pilsētām laika posmā no 1986. gada līdz šodienai. Esošie stereotipi un aizspriedumi, kas vēl joprojām eksistē starp bijušās Rietumvācijas un Austrumvācijas pilsētu iedzīvotājiem, pierāda, ka iepriekš valdošo režīmu atstātās sekas nav zudušas, kas apliecina šī vēsturiski nozīmīgā notikuma analīzes nepieciešamību un aktualitāti. Tēmas aktualitāti pierāda ne tikai esošie aizspriedumi, bet arī neatrisinātie konflikti divu valstu starpā, piemēram Ķīnā un Taivānā vai Indijā un Pakistānā. Darbā apskatītā tēma ilustrē kā valsts apvienošana…
Primera experiencia y presentación de labores investigadoras referentes a análisis de imágenes médicas para alumnos de enseñanzas medias
2019
Los Campus Científicos de Verano tienen como objetivo que los alumnos de enseñanzas medias de las opciones científico-técnicas tengan un primer contacto con la labor investigadora que se realiza en las universidades y centros de investigación. Para ello, los estudiantes participan en proyectos de una semana de duración organizados en diferentes sesiones, como la presentada en este trabajo. Enmarcado en el proyecto “Tecnología y física médicas: la innovación al servicio de la medicina”, cuyo objetivo es fomentar el interés de los alumnos en las aplicaciones tecnológicas de la ingeniería biomédica, presentamos un seminario sobre técnicas de análisis de imágenes biomédicas mediante la utilizac…
Contraddittorio, immediatezza e parità delle parti nel giudizio di appello. Estenuazioni interne e affermazioni europee
2015
Notwithstanding art. 111 Cost. and the European Convention on Human Rights, in Italy it is still allowed for the judge in Appeal - even without new evidence - to condemn the defendant after the Court of First Instance's acquittal.
Riforma in peius della sentenza di assoluzione senza rinnovare la prova orale. Una decisione che fa discutere
2013
La Corte di cassazione, con la pronuncia annotata, affronta un aspetto critico del vasto e complesso tema concernente la prova in appello, quello della possibilità per i giudici di secondo grado di procedere alla rivalutazione della prova orale precedentemente formata senza averne rinnovato l’assunzione. Secondo la Consulta, la Corte d’appello, nella specie, non avrebbe operato, come sostenuto dai ricorrenti, una pura e semplice ri-valutazione delle dichiarazioni della persona offesa, avendole apprezzate alla luce di ulteriori elementi, trascurati dal primo giudice, e valorizzati dal secondo. Mascherata, quindi, come una ri-lettura del quadro probatorio già formato nel primo giudizio, integ…
Prova tecnica e appello penale
2019
Affinché il giudice d’appello eserciti un controllo effettivo sulla razionalità delle argomentazioni scientifiche riportate in sentenza è indispensabile che s’instauri un contraddittorio tecnico efficace. A tal fine, come hanno statuito le Sezioni unite, la rinnovazione obbligatoria della prova dichiarativa (art. 603, comma 3° bis, c.p.p.) va estesa anche all’esame degli esperti. Tuttavia, il grande consesso ha lasciato fuori dai confini operativi del congegno talune ipotesi in cui, invece, parrebbe sufficiente il solo contraddittorio cartolare, facendo salvo il potere discrezionale del giudice di rinnovare l’istruzione, attorno al quale, come noto, si annidano incertezze interpretative di …