Search results for "inn"
showing 10 items of 7124 documents
Technologia Blockchain i jej zastosowanie w zarządzaniu łańcuchem dostaw
2019
Blockchain is a new technology that allows for decentralized data storage and data verification. Recently, this technology has been gaining more and more interest from representatives of various industries, including logistics and supply chain management. There are more and more voices that Blockchain technology will revolutionize existing business models. However, current research in this area are limited, especially in the logistics and supply chain. Therefore, the aim of this study is the identification of the Blockchain Technology benefits and presenting the potential areas of its application in the supply chain.
Innovacions amb blogs: desenvolupament de competències del futur mestre i benestar subjectiu docent
2012
Es descriuen tres experiències innovadores del Grau de Maestro amb blogs, orientades al desenvolupament de competències específiques i transversals: un blog de ressenyes literàries infantils; una revista digital com a espai per a la investigació i el treball col·laboratiu; i un i-portafolio per visibilizar pràctiques, avaluar progressos en l'aprenentatge i desenvolupar tutories. Es va constatar en totes elles una alta participació, motivació i implicació, i el desenvolupament de competències d'ordre superior, com les habilitats comunicatives, digitals, d'anàlisis i síntesis…. Amb això, el professorat va experimentar un alt grau de benestar subjectiu, vinculat amb la seva satisfacció en rela…
The gut microbiota: An emerging risk factor for cardiovascular and cerebrovascular disease
2018
Commensal gut microbiota have recently been implicated in cardiovascular disease (CVD) and cerebrovascular disease. Atherosclerotic plaque formation depends on the colonization status of the host. In addition to host nutrition and the related microbiota-dependent metabolic changes, activation of innate immune pathways triggers the development of atherosclerosis and supports arterial thrombosis. Gnotobiotic mouse models have uncovered that activation of Toll-like receptor-2 by gut microbial ligands supports von Willebrand factor-integrin mediated platelet deposition to the site of vascular injury. Depending on nutritional factors, the microbiota-derived choline-metabolite trimethylamine N-ox…
The Gut Microbiota as an Influencing Factor of Arterial Thrombosis
2018
The mutualistic gut microbiota does not only impact the development and function of various immune cell types, but it also influences the function of the hepatic vascular endothelium and prothrombotic platelet function. With germ-free mouse models, we have demonstrated that gut-derived microbial-associated molecular patterns could stimulate hepatic von Willebrand factor (VWF) synthesis and plasmatic VWF levels through Toll-like receptor-2 (TLR2), thus defining the extent of platelet deposition to the subendothelial matrix of the ligation-injured common carotid artery. In addition to the microbiota-derived choline metabolite trimethylamine N-oxide and the microbiota's regulatory role on the …
A biostable, anti-fouling zwitterionic polyurethane-urea based on PDMS for use in blood-contacting medical devices.
2020
Polydimethylsiloxane (PDMS) is commonly used in medical devices because it is non-toxic and stable against oxidative stress. Relatively high blood platelet adhesion and the need for chemical crosslinking through curing, however, limit its utility. In this research, a biostable PDMS-based polyurethane-urea bearing zwitterion sulfobetaine (PDMS-SB-UU) was synthesized for potential use in the fabrication or coating of blood-contacting devices, such as a conduits, artificial lungs, and microfluidic devices. The chemical structure and physical properties of synthesized PDMS-SB-UU were confirmed by (1)H-nuclear magnetic resonance ((1)H-NMR), X-ray diffraction (XRD), and uniaxial stress-strain cur…
TREM-1 ligand expression on platelets enhances neutrophil activation
2007
Abstract The triggering receptor expressed on myeloid cells 1 (TREM-1) plays an important role in the innate immune response related to severe infections and sepsis. Modulation of TREM-1–associated activation improves the outcome in rodent models for pneumonia and sepsis. However, the identity and occurrence of the natural TREM-1 ligands are so far unknown, impairing the further understanding of the biology of this receptor. Here, we report the presence of a ligand for TREM-1 on human platelets. Using a recombinant TREM-1 fusion protein, we demonstrate specific binding of TREM-1 to platelets. TREM-1–specific signals are required for the platelet-induced augmentation of polymorphonuclear leu…
Vertical ductile thinning and its contribution to the exhumation of high-pressure rocks: the Cycladic blueschist unit in the Aegean
2008
The contribution of vertical ductile thinning to the exhumation of high-pressure rocks is evaluated by estimating finite strain in 75 exhumed high-pressure rocks of the Cycladic blueschist unit in the Aegean Sea, Greece, and western Turkey. Strain data indicate heterogeneous deformation; principal stretches are 1.24–5.03 for S X , 0.63–2.53 for S Y and 0.10–0.81 for S Z , with a tensor average of S X : S Y : S Z =1.52:1.28:0.51. A 1D numerical model, which integrates velocity gradients along a vertical flow path with a steady-state orogen, is used to estimate the contribution of ductile thinning of the overburden of the high-pressure rocks to exhumation. Using a strain-rate law that is prop…
Involvement of the Pseudomonas aeruginosa MexAB–OprM efflux pump in the secretion of the metallophore pseudopaline
2020
ABSTRACTThe ability for all organisms to acquire metals from their environment is essential for life. To overcome the metal restriction imposed by the host’s nutritional immunity, bacterial pathogens exploits the use of small high metal affinity molecules called metallophores. Metallophores are first synthetized in the cytoplasm, then secreted into the medium where they sequester the metal. The metal-metallophore complex is then imported into the bacterium following binding to dedicated cell surface receptors. Recently, a new family of metallophores has been discovered in pathogenic bacteria called staphylopine in Staphylococcus aureus and pseudopaline in Pseudomonas aeruginosa. Here, we ar…
Noua Stirpium Aduersaria, perfacilis vestigatio, luculentaque accessio ad Priscorum, praesertim Dioscoridis, & Recentiorum, Materiam Medicam / Auctor…
1576
Sign.: [ ]2, A-B6, Aa-Rr6, Qq-Rr4, [cristus]-2[cristus]4, *-*****4 Port. arquitectònica. - Capll. orn. - Index de matèries en llatí, francès, alemany, italià i castellà
Characterization of grapevine defense reactions and identification of elicitors : the endopolygalacturonase 1 from Botrytis cinerea, an avirulence fu…
2002
The fight against grapevine pathogens is mainly carried out by pesticides, the continued use of which is harmful to the environment and the health of users and consumers. The main organizations in charge of viticulture set as a priority the research and use of alternatives to chemical control. However, the genetic improvement of the vine is prohibited in AOC vineyards to preserve the varietal typicity, partly responsible for the quality of the wines. In addition, research undertaken some fifteen years ago reveals that plants have their own immune defenses, which they activate on contact with the microorganisms they recognize via molecules called elicitors. In this context, the objective of …